Published in J Am Med Inform Assoc on June 30, 2009
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc (2010) 10.51
A translational engine at the national scale: informatics for integrating biology and the bedside. J Am Med Inform Assoc (2011) 2.55
VISAGE: A Query Interface for Clinical Research. AMIA Jt Summits Transl Sci Proc (2010) 2.43
The DEDUCE Guided Query tool: providing simplified access to clinical data for research and quality improvement. J Biomed Inform (2010) 2.35
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature (2012) 2.27
The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One (2012) 2.05
Grid Binary LOgistic REgression (GLORE): building shared models without sharing data. J Am Med Inform Assoc (2012) 1.92
Electronic health records-driven phenotyping: challenges, recent advances, and perspectives. J Am Med Inform Assoc (2013) 1.85
Strategies for maintaining patient privacy in i2b2. J Am Med Inform Assoc (2011) 1.83
On experiences of i2b2 (Informatics for integrating biology and the bedside) database with Japanese clinical patients' data. Bioinformation (2011) 1.82
SHRINE: enabling nationally scalable multi-site disease studies. PLoS One (2013) 1.80
The clinical research data repository of the US National Institutes of Health. Stud Health Technol Inform (2010) 1.76
Direct2Experts: a pilot national network to demonstrate interoperability among research-networking platforms. J Am Med Inform Assoc (2011) 1.75
Expressing observations from electronic medical record flowsheets in an i2b2 based clinical data repository to support research and quality improvement. AMIA Annu Symp Proc (2011) 1.46
Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc (2014) 1.40
An i2b2-based, generalizable, open source, self-scaling chronic disease registry. J Am Med Inform Assoc (2012) 1.39
Implementation of a deidentified federated data network for population-based cohort discovery. J Am Med Inform Assoc (2011) 1.35
Mission and Sustainability of Informatics for Integrating Biology and the Bedside (i2b2). EGEMS (Wash DC) (2014) 1.26
Query Health: standards-based, cross-platform population health surveillance. J Am Med Inform Assoc (2014) 1.23
Changing the research landscape: the New York City Clinical Data Research Network. J Am Med Inform Assoc (2014) 1.17
TRIAD: The Translational Research Informatics and Data Management Grid. Appl Clin Inform (2011) 1.14
Characterization of the biomedical query mediation process. AMIA Jt Summits Transl Sci Proc (2013) 1.12
Computing health quality measures using Informatics for Integrating Biology and the Bedside. J Med Internet Res (2013) 1.11
Clinical use of an enterprise data warehouse. AMIA Annu Symp Proc (2012) 1.10
Federated queries of clinical data repositories: the sum of the parts does not equal the whole. J Am Med Inform Assoc (2013) 1.06
Clinical research informatics: a conceptual perspective. J Am Med Inform Assoc (2012) 1.06
The National Institutes of Health's Biomedical Translational Research Information System (BTRIS): design, contents, functionality and experience to date. J Biomed Inform (2013) 1.05
Facilitating health data sharing across diverse practices and communities. AMIA Jt Summits Transl Sci Proc (2010) 1.05
Using electronic medical records to determine the diagnosis of clinical depression. Int J Med Inform (2011) 1.04
Desiderata for computable representations of electronic health records-driven phenotype algorithms. J Am Med Inform Assoc (2015) 1.04
A unified structural/terminological interoperability framework based on LexEVS: application to TRANSFoRm. J Am Med Inform Assoc (2013) 1.03
Design and implementation of a privacy preserving electronic health record linkage tool in Chicago. J Am Med Inform Assoc (2015) 1.00
Modular design, application architecture, and usage of a self-service model for enterprise data delivery: the Duke Enterprise Data Unified Content Explorer (DEDUCE). J Biomed Inform (2014) 1.00
A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens. Cancer Res (2015) 1.00
BigMouth: a multi-institutional dental data repository. J Am Med Inform Assoc (2014) 0.99
From information technology to informatics: the information revolution in dental education. J Dent Educ (2012) 0.94
An adaptable architecture for patient cohort identification from diverse data sources. J Am Med Inform Assoc (2013) 0.94
Multi-Institutional Sharing of Electronic Health Record Data to Assess Childhood Obesity. PLoS One (2013) 0.94
PaTH: towards a learning health system in the Mid-Atlantic region. J Am Med Inform Assoc (2014) 0.93
Data analysis and data mining: current issues in biomedical informatics. Methods Inf Med (2011) 0.93
An ICT infrastructure to integrate clinical and molecular data in oncology research. BMC Bioinformatics (2012) 0.92
Automated extraction of clinical traits of multiple sclerosis in electronic medical records. J Am Med Inform Assoc (2013) 0.92
Trends in biomedical informatics: most cited topics from recent years. J Am Med Inform Assoc (2011) 0.91
Using common table expressions to build a scalable Boolean query generator for clinical data warehouses. IEEE J Biomed Health Inform (2014) 0.91
Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: a pilot study. Psychiatry Res (2012) 0.88
A Digital Architecture for a Network-Based Learning Health System: Integrating Chronic Care Management, Quality Improvement, and Research. EGEMS (Wash DC) (2015) 0.86
Sustaining Research Networks: the Twenty-Year Experience of the HMO Research Network. EGEMS (Wash DC) (2014) 0.86
What Is Asked in Clinical Data Request Forms? A Multi-site Thematic Analysis of Forms Towards Better Data Access Support. AMIA Annu Symp Proc (2014) 0.86
A model for the electronic support of practice-based research networks. Ann Fam Med (2012) 0.84
Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc (2015) 0.84
External phenome analysis enables a rational federated query strategy to detect changing rates of treatment-related complications associated with multiple myeloma. J Am Med Inform Assoc (2013) 0.83
Using registries to identify adverse events in rheumatic diseases. Pediatrics (2013) 0.83
Building a diabetes screening population data repository using electronic medical records. J Diabetes Sci Technol (2011) 0.82
High throughput tools to access images from clinical archives for research. J Digit Imaging (2015) 0.81
Use of a rich internet application solution to present medical images. J Digit Imaging (2011) 0.81
Review and evaluation of electronic health records-driven phenotype algorithm authoring tools for clinical and translational research. J Am Med Inform Assoc (2015) 0.81
Efficiency and effectiveness evaluation of an automated multi-country patient count cohort system. BMC Med Res Methodol (2015) 0.81
Informatics-based Challenges of Building Collaborative Healthcare Research and Analysis Networks from Rural Community Health Centers. IEEE EMBS Int Conf Biomed Health Inform (2016) 0.80
ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow. Int J Biomed Data Min (2015) 0.79
OWL model of clinical trial eligibility criteria compatible with partially-known information. J Biomed Semantics (2013) 0.79
A focus area maturity model for a statewide master person index. Online J Public Health Inform (2013) 0.79
Size matters: how population size influences genotype-phenotype association studies in anonymized data. J Biomed Inform (2014) 0.78
An autism case history to review the systematic analysis of large-scale data to refine the diagnosis and treatment of neuropsychiatric disorders. Biol Psychiatry (2014) 0.78
Enabling Privacy-Preserving GWASs in Heterogeneous Human Populations. Cell Syst (2016) 0.77
An informatics research agenda to support precision medicine: seven key areas. J Am Med Inform Assoc (2016) 0.77
Realizing privacy preserving genome-wide association studies. Bioinformatics (2016) 0.76
CUSTOM-SEQ: a prototype for oncology rapid learning in a comprehensive EHR environment. J Am Med Inform Assoc (2016) 0.76
Big Data Science: Opportunities and Challenges to Address Minority Health and Health Disparities in the 21st Century. Ethn Dis (2017) 0.75
Designing Reliable Cohorts of Cardiac Patients across MIMIC and eICU. Comput Cardiol (2010) (2016) 0.75
Using the Electronic Medical Record to Examine Racial and Ethnic Differences in Depression Diagnosis and Treatment in a Primary Care Population. Prim Health Care (2012) 0.75
Reuse of clinical data. Yearb Med Inform (2014) 0.75
Ten Simple Rules to Enable Multi-site Collaborations through Data Sharing. PLoS Comput Biol (2017) 0.75
Expanding Interprofessional EHR Data in i2b2. AMIA Jt Summits Transl Sci Proc (2016) 0.75
User Satisfaction Evaluation of the EHR4CR Query Builder: A Multisite Patient Count Cohort System. Biomed Res Int (2015) 0.75
Challenges to Implementation of Global Translational Collaboration Platforms. MOJ Proteom Bioinform (2016) 0.75
An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies. Biomed Res Int (2016) 0.75
Using the CER Hub to ensure data quality in a multi-institution smoking cessation study. J Am Med Inform Assoc (2014) 0.75
Using Electronic Health Records to Support Clinical Trials: A Report on Stakeholder Engagement for EHR4CR. Biomed Res Int (2015) 0.75
Using i2b2 to Bootstrap Rural Health Analytics and Learning Networks. Conf Proc IEEE Eng Med Biol Soc (2016) 0.75
Facilitating biomedical researchers' interrogation of electronic health record data: Ideas from outside of biomedical informatics. J Biomed Inform (2016) 0.75
Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology. Cancer Inform (2017) 0.75
Using RxNorm for cross-institutional formulary data normalization within a distributed grid-computing environment. AMIA Annu Symp Proc (2011) 0.75
Secure and scalable deduplication of horizontally partitioned health data for privacy-preserving distributed statistical computation. BMC Med Inform Decis Mak (2017) 0.75
ODaCCI: Ontology-guided Data Curation for Multisite Clinical Research Data Integration in the NINDS Center for SUDEP Research. AMIA Annu Symp Proc (2017) 0.75
Precision Medicine for Heart Failure: Lessons From Oncology. Circ Heart Fail (2017) 0.75
caGrid 1.0: an enterprise Grid infrastructure for biomedical research. J Am Med Inform Assoc (2007) 6.15
Architecture of the open-source clinical research chart from Informatics for Integrating Biology and the Bedside. AMIA Annu Symp Proc (2007) 5.89
Building national electronic medical record systems via the World Wide Web. J Am Med Inform Assoc (1996) 5.45
ClinQuery: a system for online searching of data in a teaching hospital. Ann Intern Med (1989) 5.13
A security architecture for query tools used to access large biomedical databases. Proc AMIA Symp (2002) 4.75
A national human neuroimaging collaboratory enabled by the Biomedical Informatics Research Network (BIRN). IEEE Trans Inf Technol Biomed (2008) 3.84
A visual interface designed for novice users to find research patient cohorts in a large biomedical database. AMIA Annu Symp Proc (2003) 3.74
Calculating the benefits of a Research Patient Data Repository. AMIA Annu Symp Proc (2006) 2.78
Data mining by clinicians. Proc AMIA Symp (1998) 2.73
A submission model for use in the indexing, searching, and retrieval of distributed pathology case and tissue specimens. Stud Health Technol Inform (2004) 2.28
A self-scaling, distributed information architecture for public health, research, and clinical care. J Am Med Inform Assoc (2007) 1.88
Temporal expressiveness in querying a time-stamp--based clinical database. J Am Med Inform Assoc (2000) 1.76
SANDS: a service-oriented architecture for clinical decision support in a National Health Information Network. J Biomed Inform (2008) 1.62
A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network. Hum Pathol (2007) 1.59
Scaling a data retrieval and mining application to the enterprise-wide level. Proc AMIA Symp (1999) 1.25
CareWeb, a web-based medical record for an integrated health care delivery system. Int J Med Inform (1999) 1.11
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc (2010) 10.51
Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak (2006) 9.98
Managing incidental findings and research results in genomic research involving biobanks and archived data sets. Genet Med (2012) 9.65
Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci U S A (2005) 8.75
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet (2006) 7.16
Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
Creation and implications of a phenome-genome network. Nat Biotechnol (2006) 5.79
Medicine. Reestablishing the researcher-patient compact. Science (2007) 5.64
Tectonic shifts in the health information economy. N Engl J Med (2008) 5.42
Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements. Nucleic Acids Res (2004) 4.43
Electronic medical records for discovery research in rheumatoid arthritis. Arthritis Care Res (Hoboken) (2010) 4.15
Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res (2009) 4.13
Cluster analysis of gene expression dynamics. Proc Natl Acad Sci U S A (2002) 3.83
Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A (2007) 3.72
Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements. BMC Bioinformatics (2005) 3.66
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics (2005) 3.23
Portability of an algorithm to identify rheumatoid arthritis in electronic health records. J Am Med Inform Assoc (2012) 2.94
No small change for the health information economy. N Engl J Med (2009) 2.92
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics (2005) 2.83
Calculating the benefits of a Research Patient Data Repository. AMIA Annu Symp Proc (2006) 2.78
Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle. Proc Natl Acad Sci U S A (2002) 2.60
A translational engine at the national scale: informatics for integrating biology and the bedside. J Am Med Inform Assoc (2011) 2.55
Network-based analysis of affected biological processes in type 2 diabetes models. PLoS Genet (2007) 2.54
The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. PLoS One (2007) 2.52
Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51
The SMART Platform: early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc (2012) 2.48
Expression profiling and identification of novel genes involved in myogenic differentiation. FASEB J (2003) 2.30
A submission model for use in the indexing, searching, and retrieval of distributed pathology case and tissue specimens. Stud Health Technol Inform (2004) 2.28
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet (2011) 2.27
Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc (2009) 2.20
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
Effect of a pediatric hospitalist system on housestaff education and experience. Arch Pediatr Adolesc Med (2002) 2.15
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS One (2008) 2.10
The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One (2012) 2.05
The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc (2004) 2.01
Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records. Diabetes Care (2009) 2.00
Escaping the EHR trap--the future of health IT. N Engl J Med (2012) 1.96
Technical desiderata for the integration of genomic data into Electronic Health Records. J Biomed Inform (2011) 1.96
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Finding the missing link for big biomedical data. JAMA (2014) 1.90
A self-scaling, distributed information architecture for public health, research, and clinical care. J Am Med Inform Assoc (2007) 1.88
Transcriptomic analysis of human lung development. Am J Respir Crit Care Med (2009) 1.87
Strategies for maintaining patient privacy in i2b2. J Am Med Inform Assoc (2011) 1.83
SHRINE: enabling nationally scalable multi-site disease studies. PLoS One (2013) 1.80
The MAPPER database: a multi-genome catalog of putative transcription factor binding sites. Nucleic Acids Res (2005) 1.80
Validation of electronic health record phenotyping of bipolar disorder cases and controls. Am J Psychiatry (2014) 1.79
Does collocation inform the impact of collaboration? PLoS One (2010) 1.78
Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach. Inflamm Bowel Dis (2013) 1.71
The asthma kiosk: a patient-centered technology for collaborative decision support in the emergency department. J Am Med Inform Assoc (2004) 1.70
A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med (2012) 1.70
Parents as partners in obtaining the medication history. J Am Med Inform Assoc (2005) 1.67
Whose personal control? Creating private, personally controlled health records for pediatric and adolescent patients. J Am Med Inform Assoc (2008) 1.65
Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples. PLoS One (2011) 1.62
The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine. Trials (2014) 1.62
Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Inflamm Bowel Dis (2013) 1.60
A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network. Hum Pathol (2007) 1.59
AEGIS: a robust and scalable real-time public health surveillance system. J Am Med Inform Assoc (2007) 1.58
Effect of acute aldosterone administration on gene expression profile in the heart. Endocrinology (2006) 1.58
Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study. Am J Psychiatry (2012) 1.57
Training the next generation of informaticians: the impact of "BISTI" and bioinformatics--a report from the American College of Medical Informatics. J Am Med Inform Assoc (2004) 1.53
Bayesian approach to discovering pathogenic SNPs in conserved protein domains. Hum Mutat (2004) 1.51
Inter-species differences of co-expression of neighboring genes in eukaryotic genomes. BMC Genomics (2004) 1.50
Toward more transparent and reproducible omics studies through a common metadata checklist and data publications. OMICS (2014) 1.49
Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells (2006) 1.46
Identification of patients with diabetes from the text of physician notes in the electronic medical record. Diabetes Care (2005) 1.44
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. Arthritis Rheum (2013) 1.43
Linking gene expression data with patient survival times using partial least squares. Bioinformatics (2002) 1.42
Identification of a transcriptional profile associated with in vitro invasion in non-small cell lung cancer cell lines. Cancer Biol Ther (2004) 1.42
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol (2006) 1.42
QT interval and antidepressant use: a cross sectional study of electronic health records. BMJ (2013) 1.40
An i2b2-based, generalizable, open source, self-scaling chronic disease registry. J Am Med Inform Assoc (2012) 1.39
An epidemiological network model for disease outbreak detection. PLoS Med (2007) 1.31
A SNP-centric database for the investigation of the human genome. BMC Bioinformatics (2004) 1.31
A glimpse of the next 100 years in medicine. N Engl J Med (2012) 1.30
Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle. Proc Natl Acad Sci U S A (2003) 1.29
A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers. Genome Biol (2012) 1.23
Gene expression profile after cardiopulmonary bypass and cardioplegic arrest. J Thorac Cardiovasc Surg (2003) 1.23
Mychildren's: integration of a personally controlled health record with a tethered patient portal for a pediatric and adolescent population. AMIA Annu Symp Proc (2009) 1.22
Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med (2006) 1.21
Characteristics at diagnosis of type 1 diabetes in children younger than 6 years. J Pediatr (2006) 1.20
Gene expression profiling of Duchenne muscular dystrophy skeletal muscle. Neurogenetics (2003) 1.18
Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics (2004) 1.17
Tissue and process specific microRNA-mRNA co-expression in mammalian development and malignancy. PLoS One (2009) 1.17
Automated validation of genetic variants from large databases: ensuring that variant references refer to the same genomic locations. Bioinformatics (2011) 1.17
DITTO - a tool for identification of patient cohorts from the text of physician notes in the electronic medical record. AMIA Annu Symp Proc (2005) 1.15
Newborn screening program practices in the United States: notification, research, and consent. Pediatrics (2002) 1.14
Availability and quality of paraffin blocks identified in pathology archives: a multi-institutional study by the Shared Pathology Informatics Network (SPIN). BMC Cancer (2007) 1.14