Published in Diabetes Care on December 15, 2009
Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ (2011) 4.05
Next-generation phenotyping of electronic health records. J Am Med Inform Assoc (2012) 3.41
A translational engine at the national scale: informatics for integrating biology and the bedside. J Am Med Inform Assoc (2011) 2.55
The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One (2012) 2.05
Derivation and validation of automated electronic search strategies to identify pertinent risk factors for postoperative acute lung injury. Mayo Clin Proc (2011) 1.84
Validation of electronic health record phenotyping of bipolar disorder cases and controls. Am J Psychiatry (2014) 1.79
Ontology-based data integration between clinical and research systems. PLoS One (2015) 1.58
Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study. Am J Psychiatry (2012) 1.57
QT interval and antidepressant use: a cross sectional study of electronic health records. BMJ (2013) 1.40
Exploiting time in electronic health record correlations. J Am Med Inform Assoc (2011) 1.39
Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants. BMJ Open (2012) 1.13
Making big data useful for health care: a summary of the inaugural mit critical data conference. JMIR Med Inform (2014) 1.11
Probabilistic techniques for obtaining accurate patient counts in Clinical Data Warehouses. J Biomed Inform (2011) 1.07
Development of phenotype algorithms using electronic medical records and incorporating natural language processing. BMJ (2015) 1.03
Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data. PLoS One (2011) 0.86
Towards prevention of acute syndromes: electronic identification of at-risk patients during hospital admission. Appl Clin Inform (2014) 0.83
Management of diabetes across the course of disease: minimizing obesity-associated complications. Diabetes Metab Syndr Obes (2011) 0.82
Diabetes, glucose control, glucose lowering medications, and cancer risk: a 10-year population-based historical cohort. BMC Cancer (2012) 0.80
Use of an Electronic Medical Record (EMR) to Identify Glycemic Intensification Strategies in Type 2 Diabetes. J Diabetes Sci Technol (2014) 0.77
Development of a data-mining algorithm to identify ages at reproductive milestones in electronic medical records. Pac Symp Biocomput (2014) 0.76
A complementary graphical method for reducing and analyzing large data sets. Case studies demonstrating thresholds setting and selection. Methods Inf Med (2014) 0.76
Laboratory tests as short-term correlates of stroke. BMC Neurol (2016) 0.75
Supporting Multi-sourced Medication Information in i2b2. AMIA Annu Symp Proc (2015) 0.75
Tool kit for translational research. Nat Med (2010) 0.75
Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies. BMC Cardiovasc Disord (2016) 0.75
Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med (2008) 47.90
10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med (2008) 35.49
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med (2007) 33.21
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med (1998) 25.66
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med (2006) 19.09
A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med (2009) 12.15
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet (2009) 8.54
Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis. N Engl J Med (2007) 7.86
Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records. Am Heart J (2004) 6.57
Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA (2007) 5.89
Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA (2007) 5.02
Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA (2007) 4.25
Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death. Ann Intern Med (2007) 2.76
Rosiglitazone and cardiovascular risk. N Engl J Med (2007) 2.41
In defense of pharmacoepidemiology--embracing the yin and yang of drug research. N Engl J Med (2007) 2.15
A comparison of pioglitazone and rosiglitazone for hospitalization for acute myocardial infarction in type 2 diabetes. Pharmacoepidemiol Drug Saf (2007) 2.10
Coronary heart disease outcomes in patients receiving antidiabetic agents in the PharMetrics database 2000-2007. Pharmacoepidemiol Drug Saf (2008) 1.76
Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy. Arch Intern Med (2008) 1.45
Active surveillance of vaccine safety: a system to detect early signs of adverse events. Epidemiology (2005) 1.35
Lessons from the Avandia controversy: a new paradigm for the development of drugs to treat type 2 diabetes. Diabetes Care (2007) 1.00
Studies of diabetes, thiazolidinediones, and coronary heart disease. Pharmacoepidemiol Drug Saf (2007) 0.88
Signal detection in pharmacovigilance: empirical evaluation of data mining tools. Pharmacoepidemiol Drug Saf (2005) 0.84
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet (2009) 15.00
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc (2010) 10.51
Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N Engl J Med (2000) 10.05
Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak (2006) 9.98
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Managing incidental findings and research results in genomic research involving biobanks and archived data sets. Genet Med (2012) 9.65
Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci U S A (2005) 8.75
Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med (2007) 8.59
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med (2006) 7.75
A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med (2012) 7.51
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet (2006) 7.16
Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics (2002) 7.07
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories. J Am Med Inform Assoc (2009) 6.49
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
Architecture of the open-source clinical research chart from Informatics for Integrating Biology and the Bedside. AMIA Annu Symp Proc (2007) 5.89
Creation and implications of a phenome-genome network. Nat Biotechnol (2006) 5.79
Tectonic shifts in the health information economy. N Engl J Med (2008) 5.42
Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab (2006) 5.33
Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV-infected drug users. J Gen Intern Med (2002) 5.30
Glucose levels and risk of dementia. N Engl J Med (2013) 4.95
Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements. Nucleic Acids Res (2004) 4.43
Electronic medical records for discovery research in rheumatoid arthritis. Arthritis Care Res (Hoboken) (2010) 4.15
Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res (2009) 4.13
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes Care (2002) 3.96
Cluster analysis of gene expression dynamics. Proc Natl Acad Sci U S A (2002) 3.83
Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol (2008) 3.83
A visual interface designed for novice users to find research patient cohorts in a large biomedical database. AMIA Annu Symp Proc (2003) 3.74
Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A (2007) 3.72
Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements. BMC Bioinformatics (2005) 3.66
Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Med (2006) 3.60
A controlled trial of web-based diabetes disease management: the MGH diabetes primary care improvement project. Diabetes Care (2003) 3.57
A culturally tailored navigator program for colorectal cancer screening in a community health center: a randomized, controlled trial. J Gen Intern Med (2009) 3.48
Depression, self-care, and medication adherence in type 2 diabetes: relationships across the full range of symptom severity. Diabetes Care (2007) 3.40
Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004. Diabetes Care (2008) 3.33
The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes (2003) 3.23
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics (2005) 3.23
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Arch Intern Med (2011) 3.20
Information technology comes to medicine. N Engl J Med (2007) 3.16
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15
Tests of glycemia for the diagnosis of type 2 diabetes mellitus. Ann Intern Med (2002) 3.06
Tests of glycemia in diabetes. Diabetes Care (2004) 3.03
Patient-physician connectedness and quality of primary care. Ann Intern Med (2009) 3.01
Insulin sensitivity during combined androgen blockade for prostate cancer. J Clin Endocrinol Metab (2006) 2.98
Portability of an algorithm to identify rheumatoid arthritis in electronic health records. J Am Med Inform Assoc (2012) 2.94
No small change for the health information economy. N Engl J Med (2009) 2.92
Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care (2007) 2.92
Blood glucose control in type 1 diabetes with a bihormonal bionic endocrine pancreas. Diabetes Care (2012) 2.90
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics (2005) 2.83
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem (2011) 2.82
Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes (2005) 2.80
Calculating the benefits of a Research Patient Data Repository. AMIA Annu Symp Proc (2006) 2.78
Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies. Diabetes (2003) 2.76
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care (2011) 2.75
Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. JAMA (2004) 2.70
Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle. Proc Natl Acad Sci U S A (2002) 2.60
Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited. Diabetes (2008) 2.60
Association between fine particulate matter and diabetes prevalence in the U.S. Diabetes Care (2010) 2.60
A translational engine at the national scale: informatics for integrating biology and the bedside. J Am Med Inform Assoc (2011) 2.55
Network-based analysis of affected biological processes in type 2 diabetes models. PLoS Genet (2007) 2.54
The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. PLoS One (2007) 2.52
Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics (2004) 2.51
The SMART Platform: early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc (2012) 2.48
Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus. Circulation (2005) 2.46
Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes. Diabetes Care (2005) 2.45
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res (2002) 2.37
Expression profiling and identification of novel genes involved in myogenic differentiation. FASEB J (2003) 2.30
A submission model for use in the indexing, searching, and retrieval of distributed pathology case and tissue specimens. Stud Health Technol Inform (2004) 2.28
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet (2011) 2.27
Statins and risk of new-onset diabetes mellitus. Circulation (2012) 2.27
The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 2.27
Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics (2003) 2.20
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc (2009) 2.20
Comparison of hyperglycemia, hypertension, and hypercholesterolemia management in patients with type 2 diabetes. Am J Med (2002) 2.19
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16