Published in Annu Rev Physiol on January 01, 2009
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med (2011) 3.96
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96
Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell (2010) 1.93
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support. Circulation (2014) 1.76
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem (2010) 1.71
Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A (2010) 1.68
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells. PLoS Pathog (2014) 1.61
Mitochondrial and nuclear genomics and the emergence of personalized medicine. Hum Genomics (2012) 1.40
The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism? Eur J Appl Physiol (2010) 1.36
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest (2010) 1.28
Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia. Mol Cell Biol (2012) 1.28
A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. Aging Cell (2011) 1.19
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart. Circ Res (2010) 1.19
cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation. BMC Cell Biol (2010) 1.11
Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk. Cancer Epidemiol Biomarkers Prev (2011) 1.11
Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem (2011) 1.10
Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol (2012) 1.08
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. BMC Med Genomics (2010) 1.06
Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. PLoS One (2011) 1.05
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01
Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Oncogene (2012) 1.01
Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise. J Physiol (2011) 1.00
Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells. Exp Cell Res (2009) 1.00
Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem (2012) 0.99
Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Rep (2014) 0.99
Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol. Hum Mol Genet (2010) 0.97
Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol (2012) 0.96
Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. J Biol Chem (2013) 0.95
Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions. J Gerontol A Biol Sci Med Sci (2011) 0.95
The dynamics of the mitochondrial organelle as a potential therapeutic target. J Cereb Blood Flow Metab (2012) 0.94
SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY) (2013) 0.94
Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disord (2010) 0.94
Mechanism of transcription initiation by the yeast mitochondrial RNA polymerase. Biochim Biophys Acta (2012) 0.93
Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth. Mol Cell Biol (2011) 0.93
AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood (2015) 0.93
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus. J Exp Med (2016) 0.93
Spatial distribution of cellular function: the partitioning of proteins between mitochondria and the nucleus in MCF7 breast cancer cells. J Proteome Res (2012) 0.93
Mitochondria as a potential regulator of myogenesis. ScientificWorldJournal (2013) 0.92
Connecting Mitochondria, Metabolism, and Stem Cell Fate. Stem Cells Dev (2015) 0.91
Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis. Cell Rep (2013) 0.91
High-fat, low-carbohydrate diet alters myocardial oxidative stress and impairs recovery of cardiac function after ischemia and reperfusion in obese rats. Nutr Res (2013) 0.91
Altered myocardial calcium cycling and energetics in heart failure-a rational approach for disease treatment. Cell Metab (2015) 0.89
The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass. ASN Neuro (2010) 0.89
Intrauterine growth retardation increases the susceptibility of pigs to high-fat diet-induced mitochondrial dysfunction in skeletal muscle. PLoS One (2012) 0.89
Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Dis (2013) 0.88
Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Biochem J (2014) 0.88
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res (2012) 0.88
APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease. Neurobiol Aging (2012) 0.88
Gene expression patterns of oxidative phosphorylation complex I subunits are organized in clusters. PLoS One (2010) 0.88
Mitophagy in hematopoietic stem cells: the case for exploration. Autophagy (2013) 0.87
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? Int J Mol Sci (2015) 0.87
Alteration of mitochondrial function in adult rat offspring of malnourished dams. World J Diabetes (2011) 0.87
UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J Biochem Mol Toxicol (2012) 0.87
Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice. Cell Biochem Funct (2011) 0.86
Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine. Int J Mol Sci (2015) 0.86
A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. Br J Pharmacol (2014) 0.86
Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration. Int J Cell Biol (2012) 0.85
Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1. Nutr Metab (Lond) (2015) 0.85
Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 cells. Oxid Med Cell Longev (2013) 0.85
Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death Dis (2014) 0.84
Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α. Mol Endocrinol (2011) 0.84
Mice lacking PGC-1β in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance. Mol Metab (2013) 0.84
Correlates of Peripheral Blood Mitochondrial DNA Content in a General Population. Am J Epidemiol (2015) 0.84
Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet (2014) 0.84
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis (2014) 0.83
Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2012) 0.83
SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α. J Biol Chem (2012) 0.83
Reperfusion promotes mitochondrial biogenesis following focal cerebral ischemia in rats. PLoS One (2014) 0.83
Age effect on myocellular remodeling: response to exercise and nutrition in humans. Ageing Res Rev (2011) 0.82
Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis. Acta Neuropathol Commun (2014) 0.82
Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology. J Mol Endocrinol (2014) 0.82
Altered Mitochondrial Function, Mitochondrial DNA and Reduced Metabolic Flexibility in Patients With Diabetic Nephropathy. EBioMedicine (2015) 0.81
Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. Am J Physiol Endocrinol Metab (2011) 0.81
Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. Nutr Metab (Lond) (2016) 0.81
Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity. Am J Physiol Cell Physiol (2016) 0.81
Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Invest (2016) 0.80
The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos. Differentiation (2015) 0.80
Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action. Br J Pharmacol (2012) 0.80
The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth. Am J Physiol Heart Circ Physiol (2013) 0.80
Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region. PLoS Genet (2015) 0.79
Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression. Mol Neurodegener (2013) 0.79
Myoglobin concentration in skeletal muscle fibers of chronic heart failure patients. J Appl Physiol (1985) (2009) 0.79
Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women. Physiol Genomics (2015) 0.79
Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle. J Aging Res (2012) 0.78
High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy. FASEB J (2016) 0.78
Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice. J Gerontol A Biol Sci Med Sci (2014) 0.78
Echinochrome a increases mitochondrial mass and function by modulating mitochondrial biogenesis regulatory genes. Mar Drugs (2014) 0.78
Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1. Biochim Biophys Acta (2013) 0.78
Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney. PLoS One (2011) 0.77
MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging (Albany NY) (2016) 0.77
Aspirin may influence cellular energy status. Eur J Pharmacol (2014) 0.77
Differential effects of short-term β agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle. Animal (2014) 0.76
Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease. PLoS One (2015) 0.76
Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids (2015) 0.76
Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation. Cell Death Dis (2015) 0.76
N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically. Alcohol Clin Exp Res (2014) 0.76
Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle. J Appl Physiol (1985) (2015) 0.76
Population-level expression variability of mitochondrial DNA-encoded genes in humans. Eur J Hum Genet (2014) 0.76
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci U S A (2004) 3.65
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J Biol Chem (2003) 2.81
The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem (2002) 2.28
Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res (2007) 2.17
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci U S A (2007) 2.03
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev (2005) 1.92
ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol Metab (2008) 1.83
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev (2008) 1.78
Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. J Biol Chem (2009) 1.67
A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA. Mol Cell Biol (2008) 1.47
Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem (2010) 1.38
Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem (2005) 1.31
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest (2013) 1.29
ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett (2002) 1.09
Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. PLoS One (2011) 1.05
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab (2007) 1.00
Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise. J Physiol (2011) 1.00
Estrogen-related receptor gamma promotes mesenchymal-to-epithelial transition and suppresses breast tumor growth. Cancer Res (2011) 0.96
Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen. J Biol Chem (2007) 0.91
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab (2013) 0.89
Mice lacking PGC-1β in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance. Mol Metab (2013) 0.84
Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes. Biochim Biophys Acta (2013) 0.83