Published in J Gerontol A Biol Sci Med Sci on August 20, 2014
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue. J Cachexia Sarcopenia Muscle (2017) 0.75
Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction. BMC Cardiovasc Disord (2016) 0.75
Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster. Front Pharmacol (2016) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11
Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21
Mitochondria, oxidants, and aging. Cell (2005) 16.11
Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13
Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest (1950) 9.22
Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation (2002) 9.02
Protein oxidation and aging. Science (1992) 7.69
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc (2009) 4.47
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol (1985) (2000) 3.47
Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr (2007) 2.88
Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol (2009) 2.76
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther (2001) 2.51
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell (2007) 2.18
Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY) (2009) 2.01
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal (2012) 1.96
Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci (2010) 1.96
Mitochondrial biogenesis and healthy aging. Exp Gerontol (2008) 1.85
Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr (2012) 1.78
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab (2013) 1.74
(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol (2011) 1.72
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem (2010) 1.71
Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients (2010) 1.66
Mitochondria and cardiovascular aging. Circ Res (2012) 1.46
Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. Am J Pathol (1992) 1.34
Grapes, wines, resveratrol, and heart health. J Cardiovasc Pharmacol (2009) 1.32
Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity. FASEB J (2006) 1.32
Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr (2008) 1.32
Cell senescence in the aging kidney. J Am Soc Nephrol (2010) 1.30
What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus? Behav Cogn Neurosci Rev (2006) 1.26
Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther (2012) 1.25
Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress. FASEB J (2012) 1.23
Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem Biophys Res Commun (1990) 1.12
Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci (2011) 1.08
Hypertension, the Kuna, and the epidemiology of flavanols. J Cardiovasc Pharmacol (2006) 1.07
Mitochondria and PGC-1α in Aging and Age-Associated Diseases. J Aging Res (2011) 1.04
The role of PGC-1 coactivators in aging skeletal muscle and heart. IUBMB Life (2012) 1.00
Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle. Proteomics (2009) 0.99
Age, renal perfusion and function in island-dwelling indigenous Kuna Amerinds of Panama. Nephron (1999) 0.96
Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons. Biochem Biophys Res Commun (2010) 0.94
Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process. Exp Gerontol (2003) 0.93
Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy. Am J Physiol Renal Physiol (2012) 0.90
Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice. Molecules (2013) 0.87
Flavanols, the Kuna, cocoa consumption, and nitric oxide. J Am Soc Hypertens (2009) 0.86
Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem (2013) 0.83
Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver. PLoS One (2013) 0.82
(-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. Int J Cardiol (2013) 0.82
Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice. Brain Res (2010) 0.82
Consumption of polyphenol plants may slow aging and associated diseases. Curr Pharm Des (2013) 0.81
Quantitative digital in situ senescence-associated β-galactosidase assay. BMC Cell Biol (2011) 0.81
(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. Clin Sci (Lond) (2013) 0.79
Effects of (-)-epicatechin on a diet-induced rat model of cardiometabolic risk factors. Eur J Pharmacol (2014) 0.80