Published in Dev Dyn on September 01, 2009
Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers. Dev Biol (2011) 1.08
The cellular and molecular mechanisms of vertebrate lens development. Development (2014) 1.04
Planar cell polarity in the mammalian eye lens. Organogenesis (2011) 0.95
Dlg1 controls planar spindle orientation in the neuroepithelium through direct interaction with LGN. J Cell Biol (2014) 0.89
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol (2011) 0.88
Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol (2013) 0.86
Cadm1 expression and function in the mouse lens. Invest Ophthalmol Vis Sci (2011) 0.86
Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development (2014) 0.84
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83
Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development (2016) 0.78
Intrinsic and extrinsic regulatory mechanisms are required to form and maintain a lens of the correct size and shape. Exp Eye Res (2016) 0.77
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling. PLoS One (2014) 0.76
Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens. Invest Ophthalmol Vis Sci (2016) 0.75
The lens actin filament cytoskeleton: Diverse structures for complex functions. Exp Eye Res (2016) 0.75
Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation. Invest Ophthalmol Vis Sci (2017) 0.75
N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol (2017) 0.75
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science (2000) 6.44
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature (2000) 4.80
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52
Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci (2001) 4.42
Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation (1981) 3.65
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A (1997) 3.37
Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia. J Cell Biol (1996) 3.24
The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol (2008) 2.98
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol (2000) 2.79
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev (1994) 2.72
Growth factor regulation of lens development. Dev Biol (2005) 2.46
Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol (2001) 2.29
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Oncogene (2000) 2.20
Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development (1989) 1.80
Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila. Dev Biol (1989) 1.76
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. Oncogene (2002) 1.71
Get to grips: steering local actin dynamics with IQGAPs. EMBO Rep (2007) 1.68
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol (2008) 1.58
Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Dev Biol (2008) 1.53
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene (2000) 1.50
FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development (2001) 1.49
A role for caspases in lens fiber differentiation. J Cell Biol (1998) 1.47
Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci (2004) 1.40
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1). Mol Biol Cell (2003) 1.39
The crystallins: genes, proteins and diseases. Biol Chem (1997) 1.38
Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol Cell Biol (2001) 1.38
Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development (1998) 1.36
Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1. J Cell Sci (2001) 1.35
Molecular architecture of the lens fiber cell basal membrane complex. J Cell Sci (1999) 1.35
Bmp signaling is required for development of primary lens fiber cells. Development (2002) 1.33
FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Development (1995) 1.31
Apoptosis in lens development and pathology. Differentiation (2006) 1.29
Role of the executioner caspases during lens development. J Biol Chem (2005) 1.27
Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium. Mol Cell Biol (2003) 1.27
Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large. Dev Biol (2001) 1.27
E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton. J Cell Sci (1998) 1.25
Expression of a truncated FGF receptor results in defective lens development in transgenic mice. Development (1995) 1.22
Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Dev Biol (2008) 1.21
Epithelial organization of the mammalian lens. Exp Eye Res (2000) 1.19
Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev Biol (2007) 1.17
Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation (2007) 1.13
Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice. Dev Biol (1998) 1.11
Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development (2001) 1.11
Wnt signaling enhances FGF2-triggered lens fiber cell differentiation. Development (2004) 1.09
DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation. Mol Biol Cell (2001) 1.08
The ocular lens fiber membrane specific protein MIP/Aquaporin 0. J Exp Zool A Comp Exp Biol (2003) 1.08
Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. Dev Biol (2008) 1.07
A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics (2004) 1.07
Regulation of cell adhesion and migration in lens development. Int J Dev Biol (2004) 1.06
Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires fibroblast growth factor-induced ERK and JNK signaling. J Biol Chem (2004) 1.06
A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Semin Cell Dev Biol (2006) 1.06
N-cadherin function is required for differentiation-dependent cytoskeletal reorganization in lens cells in vitro. Exp Cell Res (2000) 1.06
Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development. Int J Dev Biol (2004) 1.04
Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans. Dev Biol (2004) 1.04
Role for alpha 6 integrin during lens development: Evidence for signaling through IGF-1R and ERK. Dev Dyn (2002) 1.01
Abnormal development of urogenital organs in Dlgh1-deficient mice. Development (2007) 1.00
Localization of PDZ domain containing proteins Discs Large-1 and Scribble in the mouse eye. Mol Vis (2005) 1.00
Disruption of lens fiber cell differentiation and survival at multiple stages by region-specific expression of truncated FGF receptors. Dev Biol (2000) 0.99
Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells. Cancer Sci (2006) 0.97
Spatiotemporal distribution of zonulae adherens and associated actin bundles in both epithelium and fiber cells during chicken lens development. Exp Eye Res (2000) 0.96
Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int (2005) 0.94
Deregulated cell cycle control in lens epithelial cells by expression of inhibitors of tumor suppressor function. Mech Dev (2002) 0.86
Interkinetic nuclear migration during the early stages of lens formation in the chicken embryo. J Embryol Exp Morphol (1969) 0.82
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
Extra-embryonic function of Rb is essential for embryonic development and viability. Nature (2003) 3.92
Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res (2008) 3.41
Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol (2004) 2.39
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
Mutations in Hydin impair ciliary motility in mice. J Cell Biol (2008) 2.06
Rb is critical in a mammalian tissue stem cell population. Genes Dev (2007) 1.92
The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo. J Virol (2003) 1.91
A 360-kb interchromosomal duplication of the human HYDIN locus. Genomics (2006) 1.91
Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Hum Mol Genet (2003) 1.86
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol (2009) 1.70
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol (2008) 1.58
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ (2002) 1.51
Essential role for survivin in early brain development. J Neurosci (2005) 1.44
Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci (2004) 1.40
Bmp signaling is required for development of primary lens fiber cells. Development (2002) 1.33
Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium. Mol Cell Biol (2003) 1.27
Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol (2008) 1.21
Voltage-sensitive conductances of bushy cells of the Mammalian ventral cochlear nucleus. J Neurophysiol (2007) 1.15
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Dev Dyn (2005) 1.14
Pax6 is essential for lens fiber cell differentiation. Development (2009) 1.12
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem (2013) 1.10
Ectopic Pax6 expression disturbs lens fiber cell differentiation. Invest Ophthalmol Vis Sci (2004) 1.08
Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis (2006) 1.08
Examination of the pRb-dependent and pRb-independent functions of E7 in vivo. J Virol (2005) 1.05
Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci (2009) 1.04
Regulation of neonatal development of retinal ganglion cell dendrites by neurotrophin-3 overexpression. J Comp Neurol (2009) 1.04
The function of FGF signaling in the lens placode. Dev Biol (2011) 1.01
Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction. J Am Soc Nephrol (2007) 1.00
Localization of PDZ domain containing proteins Discs Large-1 and Scribble in the mouse eye. Mol Vis (2005) 1.00
Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin. Diabetes (2008) 0.99
Cell proliferation in the absence of E2F1-3. Dev Biol (2010) 0.98
The cell adhesion gene PVRL3 is associated with congenital ocular defects. Hum Genet (2011) 0.96
Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development. Dev Biol (2011) 0.96
p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate. Mol Vis (2002) 0.95
Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract. Mol Med (2012) 0.95
A cell polarity protein aPKClambda is required for eye lens formation and growth. Dev Biol (2009) 0.94
Pathogenesis of renal injury in the megabladder mouse: a genetic model of congenital obstructive nephropathy. Pediatr Res (2010) 0.91
Toward improving therapeutic regimens for Bacillus endophthalmitis. Invest Ophthalmol Vis Sci (2008) 0.89
Neural precursors express multiple chondroitin sulfate proteoglycans, including the lectican family. Biochem Biophys Res Commun (2004) 0.89
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol (2011) 0.88
Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci (2011) 0.88
Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development. J Biol Chem (2004) 0.87
Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis. Dev Dyn (2008) 0.86
Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development (2012) 0.86
Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol (2013) 0.86
Deregulated cell cycle control in lens epithelial cells by expression of inhibitors of tumor suppressor function. Mech Dev (2002) 0.86
Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol (2008) 0.85
3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis. Dev Dyn (2012) 0.84
The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts. Exp Eye Res (2008) 0.84
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation. Oncogene (2002) 0.83
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83
Embryonic expression and regulation of the large zinc finger protein KRC. Genesis (2002) 0.83
The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis. PLoS One (2012) 0.83
Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development. Mol Vis (2004) 0.82
Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development. Gene Expr (2007) 0.82
AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development. J Clin Invest (2013) 0.82
Recombineered Xenopus tropicalis BAC expresses a GFP reporter under the control of Arx transcriptional regulatory elements in transgenic Xenopus laevis embryos. Genesis (2005) 0.82
Decreased susceptibility to NMU-induced mammary carcinogenesis in transgenic rats carrying multiple copies of a rat ras gene driven by the rat Harvey ras promoter. Oncogene (2002) 0.80
AP-2α is required after lens vesicle formation to maintain lens integrity. Dev Dyn (2014) 0.79
Conversion of mouse fibroblasts to sphere cells induced by AlbuMAXI-containing medium. Front Biosci (Elite Ed) (2012) 0.79
Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation (2010) 0.78
Unique roles for E2F1 in the mouse lens in the absence of functional pRB proteins. Invest Ophthalmol Vis Sci (2002) 0.78
Identification of distinct myocardin splice variants in the bladder. J Urol (2009) 0.76
Extending Self-Organizing Optic Cups Into Functional Ciliary Epithelium. Invest Ophthalmol Vis Sci (2016) 0.75
Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens. Invest Ophthalmol Vis Sci (2016) 0.75
Controlling molecularity and stability of hydrogen bonded G-quadruplexes by modulating the structure's periphery. Chem Commun (Camb) (2016) 0.75