Published in Nature on February 27, 2003
Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 4.66
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest (2004) 2.95
Rb regulates fate choice and lineage commitment in vivo. Nature (2010) 2.60
Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol (2013) 2.58
Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J (2003) 2.34
Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol (2004) 2.26
Cell type-specific effects of Rb deletion in the murine retina. Genes Dev (2004) 2.18
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A (2004) 2.17
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev (2008) 2.05
Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis. PLoS Biol (2008) 2.04
The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties. Invest Ophthalmol Vis Sci (2011) 2.03
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A (2009) 2.00
Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev (2004) 1.93
Rb is critical in a mammalian tissue stem cell population. Genes Dev (2007) 1.92
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev (2007) 1.81
The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol (2009) 1.78
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev (2013) 1.77
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74
Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell (2009) 1.73
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. J Cell Biol (2007) 1.72
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev (2004) 1.72
The Rb tumor suppressor is required for stress erythropoiesis. EMBO J (2004) 1.68
Retinoblastoma family genes. Oncogene (2006) 1.61
The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest (2010) 1.61
Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol (2006) 1.54
Extraembryonic expression of EPCR is essential for embryonic viability. Blood (2005) 1.49
Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles. Dev Biol (2007) 1.47
Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J (2007) 1.46
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol (2008) 1.44
The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol Cancer Res (2008) 1.43
The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene (2006) 1.41
Tensor classification of N-point correlation function features for histology tissue segmentation. Med Image Anal (2008) 1.38
Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol (2007) 1.37
The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development (2005) 1.37
RB1, development, and cancer. Curr Top Dev Biol (2011) 1.37
Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol (2007) 1.37
The retinoblastoma tumor suppressor and stem cell biology. Genes Dev (2012) 1.34
The erythroblastic island. Curr Top Dev Biol (2008) 1.32
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol (2006) 1.31
CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet (2007) 1.28
The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev (2013) 1.28
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A (2011) 1.28
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Res (2011) 1.26
Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis. PLoS Biol (2009) 1.25
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol (2007) 1.24
Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J (2003) 1.23
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice. Proc Natl Acad Sci U S A (2008) 1.22
Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? Cell Div (2007) 1.22
RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Oncotarget (2015) 1.20
Ets2 is required for trophoblast stem cell self-renewal. Dev Biol (2007) 1.20
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest (2009) 1.20
Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Mol Cell Biol (2006) 1.19
p107 regulates neural precursor cells in the mammalian brain. J Cell Biol (2004) 1.15
Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse. Blood (2007) 1.15
Proliferation and cell fate establishment during Arabidopsis male gametogenesis depends on the Retinoblastoma protein. Proc Natl Acad Sci U S A (2009) 1.14
Insights from mouse models into human retinoblastoma. Cell Div (2008) 1.13
The retinoblastoma protein is required for Ras-induced oncogenic transformation. Mol Cell Biol (2006) 1.13
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem (2009) 1.13
E2f3a and E2f3b contribute to the control of cell proliferation and mouse development. Mol Cell Biol (2008) 1.13
Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PLoS Genet (2010) 1.10
Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific. EMBO J (2004) 1.09
A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. EMBO J (2005) 1.09
The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. Nat Rev Cancer (2008) 1.08
E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev (2009) 1.07
Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol (2007) 1.07
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene (2010) 1.06
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol Cell Biol (2004) 1.06
Cell-context specific role of the E2F/Rb pathway in development and disease. Glia (2010) 1.04
Rb and N-ras function together to control differentiation in the mouse. Mol Cell Biol (2003) 1.03
G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol (2010) 1.02
p27(Kip1) is required to maintain proliferative quiescence in the adult cochlea and pituitary. Cell Cycle (2011) 1.02
Keratin 8 protection of placental barrier function. J Cell Biol (2003) 1.02
The role of imprinted genes in fetal growth abnormalities. Birth Defects Res A Clin Mol Teratol (2011) 1.00
Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev Biol (2006) 1.00
Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells. Mol Endocrinol (2009) 1.00
Retinoblastoma protein is essential for early meiotic events in Arabidopsis. EMBO J (2011) 0.99
Cell proliferation in the absence of E2F1-3. Dev Biol (2010) 0.98
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes Dev (2015) 0.98
Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol (2004) 0.97
The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans. BMC Dev Biol (2007) 0.97
An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity. Mol Cell Biol (2006) 0.96
Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage. EMBO J (2005) 0.96
Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival. Proc Natl Acad Sci U S A (2003) 0.95
p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanisms. Mol Cell Biol (2012) 0.95
Rb and hematopoiesis: stem cells to anemia. Cell Div (2008) 0.93
RB regulates pancreas development by stabilizing Pdx1. EMBO J (2011) 0.93
E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ (2013) 0.92
Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis. Cell Cycle (2007) 0.92
Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma. J Clin Invest (2012) 0.91
Id2 is dispensable for Myc-induced epidermal neoplasia. Mol Cell Biol (2004) 0.90
Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development. Mol Cell Biol (2011) 0.90
Cell cycle regulation of proliferation versus differentiation in the central nervous system. Cell Tissue Res (2014) 0.89
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans. Dev Biol (2006) 0.89
The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol (2010) 0.88
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia. Blood (2012) 0.88
Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition. Proc Natl Acad Sci U S A (2009) 0.88
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells. Genes Dev (2015) 0.87
Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta (2006) 0.87
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol (2011) 5.96
Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation (2009) 4.71
Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 4.66
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06
Role of detection method in predicting breast cancer survival: analysis of randomized screening trials. J Natl Cancer Inst (2005) 4.01
Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science (2003) 3.90
Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol (2007) 3.54
Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res (2008) 3.41
Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther (2003) 3.34
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest (2006) 3.27
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest (2007) 2.99
Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. J Invest Dermatol (2009) 2.94
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
Is breast cancer survival improving? Cancer (2004) 2.73
Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature (2008) 2.71
Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol (2002) 2.63
Development of structures and transport functions in the mouse placenta. Physiology (Bethesda) (2005) 2.61
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell (2008) 2.61
MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell (2010) 2.59
Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology (2008) 2.59
Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity (2006) 2.56
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature (2004) 2.49
Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46
Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor. Nat Methods (2008) 2.44
Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol (2004) 2.39
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res (2004) 2.28
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet (2002) 2.23
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
Genomic alterations in tumor stroma. Cancer Res (2009) 2.18
Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood (2009) 2.17
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Determinants of trophoblast lineage and cell subtype specification in the mouse placenta. Dev Biol (2005) 2.15
Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J (2010) 2.13
Mutations in Hydin impair ciliary motility in mice. J Cell Biol (2008) 2.06
The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood (2008) 2.05
Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2003) 2.04
Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2005) 1.95
Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet (2004) 1.94
Rb is critical in a mammalian tissue stem cell population. Genes Dev (2007) 1.92
A 360-kb interchromosomal duplication of the human HYDIN locus. Genomics (2006) 1.91
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc (2013) 1.90
Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Dev Biol (2007) 1.87
Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Hum Mol Genet (2003) 1.86
A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science (2007) 1.84
DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol Cell Biol (2006) 1.80
Response of a KIT-positive extra-abdominal fibromatosis to imatinib mesylate and KIT genetic analysis. J Natl Cancer Inst (2006) 1.80
Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A (2012) 1.80
Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers. J Clin Psychiatry (2010) 1.79
An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. J Lipid Res (2008) 1.78
Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res (2008) 1.78
In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice. Cancer Biol Ther (2003) 1.77
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol (2010) 1.74
Effects of berberine on glucose metabolism in vitro. Metabolism (2002) 1.74
Dilated cardiomyopathy is associated with reduced expression of the cardiac sodium channel Scn5a. Cardiovasc Res (2007) 1.73
The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev (2010) 1.73
Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest (2012) 1.72
Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Front Neural Circuits (2010) 1.71
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol (2009) 1.70
E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. Oncogene (2005) 1.69
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem (2008) 1.67
High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J (2008) 1.66
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Mol Cell (2012) 1.63
Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: a novel inspiration for development of new artificial antioxidants. Free Radic Biol Med (2007) 1.59
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem (2002) 1.59
Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem (2004) 1.58
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol (2008) 1.58
The evolution, regulation, and function of placenta-specific genes. Annu Rev Cell Dev Biol (2008) 1.58
The long-term outcomes of pediatric pleural empyema: a prospective study. Arch Pediatr Adolesc Med (2012) 1.56
Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol (2009) 1.56