PubRank

Rudolf Zechner

Author PubWeight™ 150.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004 8.58
2 Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006 7.35
3 Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 2006 6.25
4 Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 2010 4.56
5 ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med 2011 3.96
6 Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem 2006 3.74
7 Adipose triglyceride lipase contributes to cancer-associated cachexia. Science 2011 3.70
8 Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem 2001 3.10
9 Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Curr Opin Lipidol 2002 2.85
10 Cellular fatty acid metabolism and cancer. Cell Metab 2013 2.82
11 Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 2010 2.60
12 Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology 2011 2.33
13 Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab 2009 2.19
14 Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 2005 2.11
15 Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res 2008 1.95
16 Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem 2008 1.94
17 The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J Biol Chem 2008 1.80
18 Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res 2010 1.75
19 Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem 2009 1.72
20 Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab 2012 1.71
21 Species-specific identification of campylobacters by partial 16S rRNA gene sequencing. J Clin Microbiol 2003 1.70
22 The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab 2012 1.66
23 Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A 2003 1.65
24 Fate of fat: the role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta 2008 1.64
25 Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab 2011 1.64
26 Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem 2009 1.63
27 Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice. Am J Physiol Endocrinol Metab 2009 1.62
28 PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nat Genet 2012 1.55
29 Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. Am J Hum Genet 2009 1.53
30 DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res 2011 1.50
31 Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev 2013 1.49
32 Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 2003 1.47
33 Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem 2011 1.42
34 Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome 2010 1.40
35 Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids. J Lipid Res 2009 1.36
36 Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. Mol Syst Biol 2014 1.35
37 Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem 2004 1.34
38 Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training. Am J Physiol Endocrinol Metab 2008 1.33
39 G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J Lipid Res 2012 1.32
40 Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem 2012 1.32
41 The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J Biol Chem 2010 1.30
42 Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J Biol Chem 2010 1.29
43 Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem 2009 1.27
44 Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes 2011 1.25
45 Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. J Biol Chem 2002 1.22
46 The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 2006 1.22
47 Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363. J Lipid Res 2010 1.20
48 Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue. J Lipid Res 2003 1.20
49 Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase. Cardiovasc Res 2003 1.17
50 A genomic island defines subspecies-specific virulence features of the host-adapted pathogen Campylobacter fetus subsp. venerealis. J Bacteriol 2009 1.14
51 The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively. PLoS One 2011 1.14
52 Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier. J Lipid Res 2013 1.13
53 Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol 2011 1.13
54 Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake. J Biol Chem 2001 1.13
55 Letting lipids go: hormone-sensitive lipase. Curr Opin Lipidol 2003 1.09
56 Transmission of Campylobacter hyointestinalis from a pig to a human. J Clin Microbiol 2002 1.07
57 The lipolytic proteome of mouse adipose tissue. Mol Cell Proteomics 2005 1.07
58 Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice. Genomics 2008 1.07
59 Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes 2013 1.06
60 Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. Biochem J 2002 1.05
61 Fat in the skin: Triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease. Dermatoendocrinol 2011 1.05
62 Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury. Gastroenterology 2011 1.05
63 Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis 2008 1.05
64 Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem 2014 1.04
65 Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. J Biol Chem 2007 1.03
66 p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab 2012 1.02
67 Functional cardiac lipolysis in mice critically depends on comparative gene identification-58. J Biol Chem 2013 1.00
68 Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia. Hepatology 2014 0.99
69 Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity. Diabetes 2012 0.97
70 Resveratrol regulates lipolysis via adipose triglyceride lipase. J Nutr Biochem 2011 0.97
71 Cell biology: Another way to get rid of fat. Nature 2009 0.97
72 Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. J Clin Invest 2005 0.95
73 Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress. J Lipid Res 2012 0.95
74 Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population. PLoS Genet 2010 0.94
75 Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 2010 0.93
76 Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem 2011 0.93
77 Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation. J Biol Chem 2003 0.91
78 Recent insights into the structure and function of comparative gene identification-58. Curr Opin Lipidol 2011 0.91
79 Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle. Lab Invest 2003 0.90
80 Endothelial and lipoprotein lipases in human and mouse placenta. J Lipid Res 2005 0.90
81 Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver. J Lipid Res 2009 0.89
82 Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes 2013 0.89
83 Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model. J Biol Chem 2002 0.89
84 Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues. Mol Cell Proteomics 2012 0.86
85 Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers. J Neurochem 2011 0.86
86 Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovasc Res 2013 0.86
87 Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing neutral lipid storage disease with myopathy. Circ Res 2013 0.85
88 Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis. J Lipid Res 2003 0.85
89 Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice. Br J Pharmacol 2002 0.84
90 Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum. Biochem J 2006 0.83
91 Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator? Curr Opin Lipidol 2014 0.80
92 LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells. Atherosclerosis 2006 0.78
93 The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes. J Lipid Res 2013 0.78
94 Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. Mol Syst Biol 2015 0.77
95 Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice. Nat Commun 2017 0.75
96 Dependence of lipoprotein-lipase-catalyzed triacylglycerol hydrolysis on droplet size of synthetic monodisperse emulsions measured with static light scattering. J Colloid Interface Sci 2004 0.75