Published in Proc Natl Acad Sci U S A on August 03, 2009
Coordinating DNA replication by means of priming loop and differential synthesis rate. Nature (2009) 2.16
Single-molecule studies reveal the function of a third polymerase in the replisome. Nat Struct Mol Biol (2011) 1.26
Dynamic coupling between the motors of DNA replication: hexameric helicase, DNA polymerase, and primase. Curr Opin Chem Biol (2011) 1.24
DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair. FEMS Microbiol Rev (2012) 1.06
E. coli DNA replication in the absence of free β clamps. EMBO J (2011) 1.04
Protein-DNA complexes are the primary sources of replication fork pausing in Escherichia coli. Proc Natl Acad Sci U S A (2013) 0.99
New insights into replisome fluidity during chromosome replication. Trends Biochem Sci (2012) 0.98
Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies. Methods Mol Biol (2011) 0.95
Manipulating replisome dynamics to enhance lambda Red-mediated multiplex genome engineering. Nucleic Acids Res (2012) 0.94
Clamp loader ATPases and the evolution of DNA replication machinery. BMC Biol (2012) 0.92
Single-molecule analysis of the Escherichia coli replisome and use of clamps to bypass replication barriers. FEBS Lett (2010) 0.91
Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies. Nat Rev Microbiol (2013) 0.90
A solution to release twisted DNA during chromosome replication by coupled DNA polymerases. Nature (2013) 0.90
cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ. Elife (2015) 0.84
A Replisome's journey through the bacterial chromosome. Front Microbiol (2015) 0.83
High-throughput single-molecule studies of protein-DNA interactions. FEBS Lett (2014) 0.83
Replication-fork dynamics. Cold Spring Harb Perspect Biol (2014) 0.81
Stability of blocked replication forks in vivo. Nucleic Acids Res (2015) 0.80
Insights into Okazaki fragment synthesis by the T4 replisome: the fate of lagging-strand holoenzyme components and their influence on Okazaki fragment size. J Biol Chem (2013) 0.78
Kinetic characterization of exonuclease-deficient Staphylococcus aureus PolC, a C-family replicative DNA polymerase. PLoS One (2013) 0.78
Diversity of the DNA replication system in the Archaea domain. Archaea (2014) 0.78
A proposal: Source of single strand DNA that elicits the SOS response. Front Biosci (Landmark Ed) (2013) 0.78
Replisome speed determines the efficiency of the Tus-Ter replication termination barrier. Nature (2015) 0.77
Frequent exchange of the DNA polymerase during bacterial chromosome replication. Elife (2017) 0.77
Replisome mechanics: lagging strand events that influence speed and processivity. Nucleic Acids Res (2014) 0.77
High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases. Nucleic Acids Res (2016) 0.75
One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain. Biophys J (2017) 0.75
Single-molecule visualization of fast polymerase turnover in the bacterial replisome. Elife (2017) 0.75
A new direct single-molecule observation method for DNA synthesis reaction using fluorescent replication protein A. Sensors (Basel) (2014) 0.75
Bacterial and Eukaryotic Replisome Machines. JSM Biochem Mol Biol (2016) 0.75
Independent and Stochastic Action of DNA Polymerases in the Replisome. Cell (2017) 0.75
The energy landscapes and motions of proteins. Science (1991) 18.93
Single-molecule enzymatic dynamics. Science (1998) 8.24
Cellular DNA replicases: components and dynamics at the replication fork. Annu Rev Biochem (2005) 5.50
Single-molecule studies of the effect of template tension on T7 DNA polymerase activity. Nature (2000) 3.98
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (2003) 3.22
Replisome-mediated DNA replication. Annu Rev Biochem (2001) 3.21
Trading places on DNA--a three-point switch underlies primer handoff from primase to the replicative DNA polymerase. Cell (1999) 2.51
Efficient in vitro replication of double-stranded DNA templates by a purified T4 bacteriophage replication system. J Biol Chem (1980) 2.22
Characterization of a triple DNA polymerase replisome. Mol Cell (2007) 2.04
Coordinated leading and lagging strand DNA synthesis on a minicircular template. Mol Cell (1998) 2.03
Devoted to the lagging strand-the subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assembly. EMBO J (1998) 1.97
An explanation for lagging strand replication: polymerase hopping among DNA sliding clamps. Cell (1994) 1.94
Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequences. Mol Microbiol (2003) 1.93
The chi psi subunits of DNA polymerase III holoenzyme bind to single-stranded DNA-binding protein (SSB) and facilitate replication of an SSB-coated template. J Biol Chem (1998) 1.80
Functional uncoupling of twin polymerases: mechanism of polymerase dissociation from a lagging-strand block. J Biol Chem (2004) 1.66
Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase. Proc Natl Acad Sci U S A (2009) 1.64
Organized arrays of individual DNA molecules tethered to supported lipid bilayers. Langmuir (2006) 1.63
The Escherichia coli preprimosome and DNA B helicase can form replication forks that move at the same rate. J Biol Chem (1987) 1.59
Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. I. Organization of the clamp loader. J Biol Chem (1995) 1.49
Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers. J Biol Chem (2006) 1.43
Real-time single-molecule observation of rolling-circle DNA replication. Nucleic Acids Res (2009) 1.30
Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins. J Mol Biol (2002) 1.24
Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. II. Frequency of primer synthesis and efficiency of primer utilization control Okazaki fragment size. J Biol Chem (1992) 1.24
Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteins. J Biol Chem (1998) 1.18
A function for the psi subunit in loading the Escherichia coli DNA polymerase sliding clamp. J Biol Chem (2007) 1.12
Replisome dynamics and use of DNA trombone loops to bypass replication blocks. Mol Biosyst (2008) 0.95
Single-molecule studies of fork dynamics in Escherichia coli DNA replication. Nat Struct Mol Biol (2008) 0.90
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell (2006) 1.94
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem (2011) 1.67
The DnaC helicase loader is a dual ATP/ADP switch protein. EMBO J (2002) 1.42
Competitive processivity-clamp usage by DNA polymerases during DNA replication and repair. EMBO J (2003) 1.42
A peptide switch regulates DNA polymerase processivity. Proc Natl Acad Sci U S A (2003) 1.29
Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen. J Biol Chem (2003) 1.19
Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex. Eur J Biochem (2004) 1.12
Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. Chem Res Toxicol (2008) 1.12
Conserved interactions in the Staphylococcus aureus DNA PolC chromosome replication machine. J Biol Chem (2005) 0.95
A solution to release twisted DNA during chromosome replication by coupled DNA polymerases. Nature (2013) 0.90
Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit. J Mol Biol (2004) 0.84
Protein trafficking on sliding clamps. Philos Trans R Soc Lond B Biol Sci (2004) 0.81
A novel function for the conserved glutamate residue in the walker B motif of replication factor C. Genes (Basel) (2013) 0.80
The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA. J Biol Chem (2014) 0.77
DNA polymerases are error-prone at RecA-mediated recombination intermediates. Cell Cycle (2013) 0.75