The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins.

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Published in Viruses on July 08, 2011

Authors

Bharatwaj Sowrirajan1, Edward Barker

Author Affiliations

1: Department of Immunology and Microbiology, Rush University Medical Center, 1735 West Harrison St, Chicago, IL 60612, USA. bharatwaj_sowrirajan@rush.edu

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NK cell recognition. Annu Rev Immunol (2005) 14.40

Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46

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Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol (2008) 7.88

Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med (1989) 7.52

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med (1996) 7.08

Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol (2001) 7.07

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature (1998) 6.94

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity (1999) 6.80

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell (1998) 5.89

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity (2001) 5.42

Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell (1991) 5.10

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4. J Virol (1992) 5.05

An activating immunoreceptor complex formed by NKG2D and DAP10. Science (1999) 4.56

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature (1998) 4.47

Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet (2006) 4.42

Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood (2005) 3.99

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism. J Virol (2009) 3.67

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog (2009) 3.66

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase. Cell Cycle (2007) 3.66

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat Med (1998) 3.61

Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J Immunol (1983) 3.58

Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J Exp Med (2005) 3.41

Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity (1996) 3.33

Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev (2006) 3.30

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J (1998) 3.17

Formation and function of the lytic NK-cell immunological synapse. Nat Rev Immunol (2008) 3.17

Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med (1998) 3.09

Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med (1999) 3.08

Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing. Proc Natl Acad Sci U S A (1981) 3.06

Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J (2003) 3.06

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity (1998) 2.95

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol (2000) 2.95

The human natural killer cell immune synapse. Proc Natl Acad Sci U S A (1999) 2.82

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J Exp Med (1995) 2.75

Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2). J Exp Med (1992) 2.69

Vav-family proteins in T-cell signalling. Curr Opin Immunol (2005) 2.67

Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med (2002) 2.64

Fatal varicella associated with selective natural killer cell deficiency. J Pediatr (2005) 2.60

2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med (1998) 2.48

Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Annu Rev Immunol (2001) 2.45

CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. J Virol (1998) 2.38

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4. Nat Immunol (2007) 2.28

SAP couples Fyn to SLAM immune receptors. Nat Cell Biol (2003) 2.27

Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J Biol Chem (2003) 2.26

Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol (2003) 2.15

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med (1991) 2.14

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity (2005) 2.11

Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Immunity (2008) 2.03

Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses. Immunity (2003) 2.03

LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol (2004) 2.00

Fas-mediated cytotoxicity by freshly isolated natural killer cells. J Exp Med (1995) 1.97

HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system. Virol J (2007) 1.89

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells. J Biol Chem (1993) 1.88

Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity (1996) 1.87

NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J Exp Med (2001) 1.86

Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor. J Immunol (1983) 1.84

Cellular ligands of activating NK receptors. Trends Immunol (2005) 1.84

HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood (2007) 1.83

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Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev (1997) 1.77

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Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe (2010) 1.74

Phospholipase C-gamma as a signal-transducing element. Exp Cell Res (1999) 1.74

Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A (2002) 1.72

HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. PLoS Pathog (2009) 1.71

Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II. Eur J Biochem (1992) 1.70

A human killer inhibitory receptor specific for HLA-A1,2. J Immunol (1996) 1.70

Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol (2004) 1.66

Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. J Gen Virol (2007) 1.63

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Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood (2005) 1.61

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Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu. J Virol (2010) 1.40

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. Mol Cell Biol (2004) 1.38

Analysis of effector mechanisms against HTLV-I- and HTLV-III/LAV-infected lymphoid cells. J Immunol (1986) 1.37

Human immunodeficiency virus type 1 (HIV-1) Vpr functions as an immediate-early protein during HIV-1 infection. J Virol (1999) 1.37

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Proc Natl Acad Sci U S A (2011) 1.35

HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2. Mol Biol Cell (2007) 1.32

Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells. J Virol (2003) 1.32

Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain. J Biol Chem (1994) 1.30

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In vivo significance of NK cell on resistance against virus (HSV-1) infections in mice. J Immunol (1984) 1.29

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol (2002) 1.29

HIV-1 Vpr: mechanisms of G2 arrest and apoptosis. Exp Mol Pathol (2008) 1.29

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