Michael Otto

Author PubWeight™ 195.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Community-associated meticillin-resistant Staphylococcus aureus. Lancet 2010 9.07
2 Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis 2006 8.17
3 Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007 7.75
4 Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 2007 5.95
5 Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification. Proc Natl Acad Sci U S A 2008 4.38
6 Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis 2008 4.16
7 Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A 2009 3.89
8 Staphylococcus epidermidis infections. Microbes Infect 2002 3.45
9 RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell 2008 3.44
10 Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol 2004 3.26
11 A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem 2004 3.05
12 Quorum-sensing control of biofilm factors in Staphylococcus epidermidis. J Infect Dis 2003 2.82
13 The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol 2008 2.78
14 Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe 2010 2.64
15 Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. PLoS One 2008 2.62
16 MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med 2012 2.61
17 Global changes in Staphylococcus aureus gene expression in human blood. PLoS One 2011 2.61
18 Essential Staphylococcus aureus toxin export system. Nat Med 2013 2.50
19 The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol Microbiol 2007 2.45
20 How Staphylococcus aureus biofilms develop their characteristic structure. Proc Natl Acad Sci U S A 2012 2.43
21 Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci U S A 2007 2.34
22 Staphylococcus quorum sensing in biofilm formation and infection. Int J Med Microbiol 2006 2.25
23 Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection. Cell Host Microbe 2008 2.20
24 Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis 2011 2.19
25 Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol 2010 2.13
26 Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains. J Infect Dis 2010 2.13
27 A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation. J Infect Dis 2009 2.12
28 Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms. J Infect Dis 2004 2.09
29 Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am 2009 2.01
30 Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J Clin Invest 2010 2.00
31 Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus. J Immunol 2008 1.97
32 Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog 2009 1.89
33 Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo. J Infect Dis 2004 1.86
34 Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect Immun 2011 1.79
35 The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis 2009 1.74
36 Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins. Cell Microbiol 2004 1.74
37 Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One 2009 1.74
38 Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proc Natl Acad Sci U S A 2011 1.70
39 Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. J Clin Invest 2005 1.64
40 Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog 2010 1.60
41 Synthesis and deformylation of Staphylococcus aureus delta-toxin are linked to tricarboxylic acid cycle activity. J Bacteriol 2003 1.59
42 Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol 2013 1.56
43 Staphylococcus δ-toxin induces allergic skin disease by activating mast cells. Nature 2013 1.56
44 Antimicrobial activity of community-associated methicillin-resistant Staphylococcus aureus is caused by phenol-soluble modulin derivatives. J Biol Chem 2011 1.51
45 Role of the luxS quorum-sensing system in biofilm formation and virulence of Staphylococcus epidermidis. Infect Immun 2006 1.51
46 The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol 2006 1.46
47 Staphylococcus epidermidis polysaccharide intercellular adhesin production significantly increases during tricarboxylic acid cycle stress. J Bacteriol 2005 1.44
48 Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. Proc Natl Acad Sci U S A 2004 1.42
49 Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. PLoS One 2009 1.42
50 Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates. Genome Biol 2012 1.38
51 Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis. Microbes Infect 2011 1.37
52 Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus. J Bacteriol 2011 1.36
53 Neutrophil responses to staphylococcal pathogens and commensals via the formyl peptide receptor 2 relates to phenol-soluble modulin release and virulence. FASEB J 2010 1.31
54 Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. J Biol Chem 2010 1.29
55 Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhesin synthesis, biofilm formation, and pathogenesis. Infect Immun 2007 1.27
56 Characterization of the Staphylococcus epidermidis accessory-gene regulator response: quorum-sensing regulation of resistance to human innate host defense. J Infect Dis 2006 1.25
57 Molecular basis of in vivo biofilm formation by bacterial pathogens. Chem Biol 2012 1.23
58 Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction. Antimicrob Agents Chemother 2010 1.22
59 Phenol-soluble modulins--critical determinants of staphylococcal virulence. FEMS Microbiol Rev 2014 1.21
60 Genome-wide analysis of ruminant Staphylococcus aureus reveals diversification of the core genome. J Bacteriol 2008 1.21
61 Understanding the significance of Staphylococcus epidermidis bacteremia in babies and children. Curr Opin Infect Dis 2010 1.20
62 Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense. J Immunol 2004 1.17
63 Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics. Infect Immun 2005 1.17
64 Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipids. Antimicrob Agents Chemother 2009 1.16
65 Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves. Clin Epidemiol 2013 1.15
66 Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus. Cell Microbiol 2006 1.14
67 AI-2-dependent gene regulation in Staphylococcus epidermidis. BMC Microbiol 2008 1.12
68 Development of real-time in vivo imaging of device-related Staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to infection. J Infect Dis 2008 1.11
69 Combining pharmacotherapy with cognitive behavioral therapy: traditional and new approaches. J Trauma Stress 2006 1.11
70 Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants. Microbes Infect 2010 1.11
71 Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin PSM-mec in methicillin-resistant Staphylococcus aureus. PLoS One 2011 1.07
72 Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2010 1.07
73 Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α. Cell Microbiol 2013 1.06
74 Conversion of Staphylococcus epidermidis strains from commensal to invasive by expression of the ica locus encoding production of biofilm exopolysaccharide. Infect Immun 2005 1.06
75 Furanone at subinhibitory concentrations enhances staphylococcal biofilm formation by luxS repression. Antimicrob Agents Chemother 2009 1.06
76 TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One 2010 1.04
77 An antidote for Staphylococcus aureus pneumonia? J Exp Med 2008 1.03
78 Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: recommendations from the HCV DRAG. Gastroenterology 2011 1.03
79 The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections. Expert Opin Ther Targets 2012 0.98
80 Pathogenomic analysis of the common bovine Staphylococcus aureus clone (ET3): emergence of a virulent subtype with potential risk to public health. J Infect Dis 2008 0.97
81 Role of ClpP in biofilm formation and virulence of Staphylococcus epidermidis. Microbes Infect 2007 0.96
82 Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing. PLoS Pathog 2013 0.96
83 The isolation and analysis of phenol-soluble modulins of Staphylococcus epidermidis. Methods Mol Biol 2014 0.96
84 Children dying from cancer: parents' perspectives on symptoms, quality of life, characteristics of death, and end-of-life decisions. J Palliat Care 2012 0.96
85 SarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis. J Infect Dis 2008 0.95
86 Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2013 0.92
87 Phenol-soluble modulins in staphylococci: What are they originally for? Commun Integr Biol 2012 0.92
88 The virulence regulator Agr controls the staphylococcal capacity to activate human neutrophils via the formyl peptide receptor 2. J Innate Immun 2011 0.90
89 Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol 2013 0.89
90 sarA negatively regulates Staphylococcus epidermidis biofilm formation by modulating expression of 1 MDa extracellular matrix binding protein and autolysis-dependent release of eDNA. Mol Microbiol 2012 0.89
91 Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections. Expert Opin Investig Drugs 2015 0.89
92 Complete genome sequence of a Pantón-Valentine leukocidin-negative community-associated methicillin-resistant Staphylococcus aureus strain of sequence type 72 from Korea. PLoS One 2013 0.87
93 Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423. Biochem Pharmacol 2004 0.86
94 The eukaryotic-type serine/threonine protein kinase Stk is required for biofilm formation and virulence in Staphylococcus epidermidis. PLoS One 2011 0.86
95 Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide. FASEB J 2013 0.86
96 Role of spx in biofilm formation of Staphylococcus epidermidis. FEMS Immunol Med Microbiol 2010 0.86
97 Did increased availability of pediatric palliative care lead to improved palliative care outcomes in children with cancer? J Palliat Med 2013 0.85
98 Personality factors associated with methadone maintenance dose. Am J Drug Alcohol Abuse 2008 0.85
99 The biofilm exopolysaccharide polysaccharide intercellular adhesin--a molecular and biochemical approach. Methods Mol Biol 2008 0.84
100 A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One 2012 0.84
101 Community-associated MRSA: a dangerous epidemic. Future Microbiol 2007 0.84
102 Control of antimicrobial peptide synthesis by the agr quorum sensing system in Staphylococcus epidermidis: activity of the lantibiotic epidermin is regulated at the level of precursor peptide processing. Peptides 2003 0.83
103 Antibiotic multiresistance strictly associated with IS256 and ica genes in Staphylococcus epidermidis strains from implant orthopedic infections. J Biomed Mater Res A 2007 0.83
104 How can Staphylococcus aureus phenol-soluble modulins be targeted to inhibit infection? Future Microbiol 2013 0.81
105 Specificity grouping of the accessory gene regulator quorum-sensing system of Staphylococcus epidermidis is linked to infection. Arch Microbiol 2004 0.81
106 Understanding the epidemic of community-associated MRSA and finding a cure: are we asking the right questions? Expert Rev Anti Infect Ther 2009 0.80
107 How Staphylococcus aureus breaches our skin to cause infection. J Infect Dis 2012 0.78
108 ygs is a novel gene that influences biofilm formation and the general stress response of Staphylococcus epidermidis. Infect Immun 2010 0.78
109 Enterococcus faecium stimulates human neutrophils via the formyl-peptide receptor 2. PLoS One 2012 0.78
110 Increased Community-Associated Infections Caused by Panton-Valentine Leukocidin-Negative MRSA, Shanghai, 2005-2014. Emerg Infect Dis 2016 0.76
111 Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model. PLoS One 2013 0.76
112 Molecular characterization of an early invasive Staphylococcus epidermidis prosthetic joint infection. Microb Drug Resist 2011 0.76
113 Combination prophylactic therapy with rifampin increases efficacy against an experimental Staphylococcus epidermidis subcutaneous implant-related infection. Antimicrob Agents Chemother 2014 0.76
114 Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2006 (1st edition). Antivir Chem Chemother 2006 0.75
115 Linezolid Exerts Greater Bacterial Clearance but No Modification of Host Lung Gene Expression Profiling: A Mouse MRSA Pneumonia Model. PLoS One 2013 0.75
116 The agr function and polymorphism: impact on Staphylococcus aureus susceptibility to photoinactivation. J Photochem Photobiol B 2013 0.75
117 Conduction mechanisms and environmental sensitivity of solution-processed silicon nanoparticle layers for thin-film transistors. Small 2011 0.75
118 Methods molecular biology. Preface. Methods Mol Biol 2008 0.75
119 Correction: Identification and treatment of the Staphylococcus aureus reservoir in vivo. J Exp Med 2016 0.75
120 How colonization factors are linked to outbreaks of methicillin-resistant Staphylococcus aureus: the roles of SasX and ACME. Biomol Concepts 2013 0.75
121 Serotonin antagonist profiling on 5HT2A and 5HT2C receptors by nonequilibrium intracellular calcium response using an automated flow-through fluorescence analysis system, HT-PS 100. J Biomol Screen 2002 0.75