Published in Carcinogenesis on September 04, 2009
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology (2015) 1.24
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. J Gastroenterol (2012) 1.18
Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. World J Gastroenterol (2015) 1.14
Wnt signaling specifies and patterns intestinal endoderm. Mech Dev (2011) 1.14
Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology (2010) 1.05
Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2). J Biol Chem (2010) 1.03
Right-side and left-side colon cancer follow different pathways to relapse. Mol Carcinog (2011) 1.02
CDX2 is an amplified lineage-survival oncogene in colorectal cancer. Proc Natl Acad Sci U S A (2012) 0.99
Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus. PLoS One (2011) 0.95
Molecular and pathogenetic aspects of tumor budding in colorectal cancer. Front Med (Lausanne) (2015) 0.94
FOXQ1, a novel target of the Wnt pathway and a new marker for activation of Wnt signaling in solid tumors. PLoS One (2013) 0.89
Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis. Dev Biol (2010) 0.89
Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet (2013) 0.88
Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells. PLoS One (2012) 0.88
Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane. Am J Physiol Gastrointest Liver Physiol (2010) 0.86
Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. Exp Biol Med (Maywood) (2014) 0.86
Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer. Front Oncol (2013) 0.84
Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Res (2011) 0.79
Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-β-catenin axis. Oncotarget (2016) 0.77
CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer. Cancer Biol Ther (2012) 0.77
Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. World J Gastroenterol (2015) 0.77
Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia. Oncotarget (2015) 0.77
The contribution of cell phenotype to the behavior of gastric cancer. Gastric Cancer (2013) 0.76
CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget (2016) 0.75
RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation. PLoS One (2014) 0.75
Recombinant lentivirus with enhanced expression of caudal-related homeobox protein 2 inhibits human colorectal cancer cell proliferation in vitro. Mol Med Rep (2015) 0.75
Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death Differ (2017) 0.75
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol (2001) 4.04
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci (1999) 3.55
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Mol Cell (1999) 3.15
An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol (1996) 2.93
Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J Biol (2004) 2.71
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev (2000) 2.65
Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell (2009) 2.55
Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development (2007) 2.50
A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol (1994) 2.42
CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology (1997) 2.23
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet (2003) 1.99
The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther (2004) 1.90
The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86
Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol (1996) 1.84
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am J Pathol (1995) 1.84
Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene (2001) 1.74
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut (2003) 1.70
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene (2005) 1.66
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology (2002) 1.62
Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. J Biol Chem (2003) 1.57
Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. EMBO J (2001) 1.45
Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A (2001) 1.35
The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res (2005) 1.31
Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc Natl Acad Sci U S A (2004) 1.27
Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem (1998) 1.27
Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia. Proc Natl Acad Sci U S A (2004) 1.27
DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. J Biol Chem (2002) 1.26
Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology (1999) 1.25
Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology (2001) 1.18
CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene (2006) 1.11
Gut-enriched Krüppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. FEBS Lett (2002) 1.08
Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells. J Biol Chem (2005) 1.06
Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J Biol Chem (2004) 1.02
Sucrase-isomaltase gene transcription requires the hepatocyte nuclear factor-1 (HNF-1) regulatory element and is regulated by the ratio of HNF-1 alpha to HNF-1 beta. J Biol Chem (2001) 1.02
Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells. Am J Physiol Gastrointest Liver Physiol (2004) 1.00
The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am J Physiol Gastrointest Liver Physiol (2007) 1.00
The caudal-related homeodomain protein Cdx1 inhibits proliferation of intestinal epithelial cells by down-regulation of D-type cyclins. J Biol Chem (2000) 0.97
Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2. Mol Cancer Res (2008) 0.95
The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine. Neoplasia (2008) 0.91
Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma. Cancer Res (2001) 0.88
Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. Oncogene (2003) 0.85
A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas. Carcinogenesis (2007) 0.85
The genetic pathogenesis of colorectal cancer. Hematol Oncol Clin North Am (2002) 0.84
Regulation of sucrase and lactase in developing rats: role of nuclear factors that bind to two gene regulatory elements. Gastroenterology (1997) 0.79
Overexpression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma. Clin Cancer Res (2004) 2.13
The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther (2004) 1.90
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A (2012) 1.82
Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene (2004) 1.77
Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus. PLoS One (2008) 1.34
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A (2010) 1.32
Granulocytapheresis is useful as an alternative therapy in patients with steroid-refractory or -dependent ulcerative colitis. Inflamm Bowel Dis (2004) 1.29
An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment. Am J Gastroenterol (2009) 1.24
Thirteen-year experience in lung transplantation for emphysema. Ann Thorac Surg (2002) 1.21
Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus. Gastroenterology (2010) 1.18
Systemic and targeted therapy for advanced colon cancer. Expert Rev Gastroenterol Hepatol (2008) 1.12
Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology (2010) 1.05
Chemoresistance is associated with cancer stem cell-like properties and epithelial-to-mesenchymal transition in pancreatic cancer cells. Anticancer Res (2012) 1.04
Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J Biol Chem (2004) 1.02
Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells. Am J Physiol Gastrointest Liver Physiol (2004) 1.00
The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am J Physiol Gastrointest Liver Physiol (2007) 1.00
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells. Gastric Cancer (2012) 0.99
Reliability for grading acute rejection and airway inflammation after lung transplantation. J Heart Lung Transplant (2005) 0.98
Rho modulates hepatic sinusoidal endothelial fenestrae via regulation of the actin cytoskeleton in rat endothelial cells. Lab Invest (2004) 0.97
The predictive value of bronchiolitis obliterans syndrome stage 0-p. Am J Respir Crit Care Med (2003) 0.97
Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis (2008) 0.96
H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer. Dig Dis Sci (2012) 0.96
Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus. PLoS One (2011) 0.95
Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2. Mol Cancer Res (2008) 0.95
A case of Behçet's disease accompanied by colitis with longitudinal ulcers and granuloma. J Gastroenterol Hepatol (2002) 0.94
Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells. Cancer Sci (2013) 0.94
How changes in Washington University's Medicare coordinated care demonstration pilot ultimately achieved savings. Health Aff (Millwood) (2012) 0.92
The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine. Neoplasia (2008) 0.91
Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia. Prog Mol Biol Transl Sci (2010) 0.89
Lung transplantation for pulmonary vascular disease. Ann Thorac Surg (2002) 0.88
Cox2 and β-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditions. Neoplasia (2011) 0.88
Molecular mechanisms of Barrett's esophagus and adenocarcinoma. Ann N Y Acad Sci (2011) 0.88
Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane. Am J Physiol Gastrointest Liver Physiol (2010) 0.86
Abdominal-pelvic lymphoproliferative disease after lung transplantation: presentation and outcome. Transplantation (2004) 0.86
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. Stem Cell Res Ther (2013) 0.83
Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Cell Cycle (2014) 0.83
A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation. J Heart Lung Transplant (2007) 0.83
Lower doses of 6-mercaptopurine/azathioprine bring enough clinical efficacy and therapeutic concentration of erythrocyte 6-mercaptopurine metabolite in Japanese IBD patients. J Crohns Colitis (2008) 0.83
Math1/Atoh1 contributes to intestinalization of esophageal keratinocytes by inducing the expression of Muc2 and Keratin-20. Dig Dis Sci (2011) 0.82
Impact of prophylaxis with cytogam alone on the incidence of CMV viremia in CMV-seropositive lung transplant recipients. J Heart Lung Transplant (2003) 0.82
Yield of surveillance bronchoscopy for acute rejection and lymphocytic bronchitis/bronchiolitis after lung transplantation. J Heart Lung Transplant (2004) 0.81
A comparison of basiliximab and anti-thymocyte globulin as induction agents after lung transplantation. J Heart Lung Transplant (2005) 0.80
Prediction of survival and complications after percutaneous endoscopic gastrostomy in an individual by using clinical factors with an artificial neural network system. Eur J Gastroenterol Hepatol (2009) 0.80
At the crossroads in the management of gastroesophageal junction carcinomas-where do we go from here? Gastrointest Cancer Res (2008) 0.80
Barrett's esophagus: genetic and cell changes. Ann N Y Acad Sci (2011) 0.79
5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis. Anticancer Res (2012) 0.79
Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation. Anticancer Res (2012) 0.77
Modelling Barrett's oesophagus. Biochem Soc Trans (2010) 0.77
Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice. Cancer Biol Ther (2005) 0.76
To differentiate or proliferate? The interaction between PI3K/PTEN and Cdx2. Gastroenterology (2002) 0.75
The modulation of IGF-1 signalling by the intestine-specific factor CDX2. Gut (2009) 0.75
You're the flight surgeon: aortic aneurysm. Aviat Space Environ Med (2012) 0.75
Phase I study of combination chemotherapy consisting of paclitaxel, cisplatin, and S-1 in patients with unresectable gastric cancer (KOGC-02). Anticancer Res (2012) 0.75
[A case of metastatic esophageal cancer - endoscopic resection of the primary site following systemic chemotherapies]. Gan To Kagaku Ryoho (2011) 0.75