Published in Gut on July 13, 2006
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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res (2011) 1.58
Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract. World J Gastroenterol (2008) 1.51
Vitamin D and cancer: a review of molecular mechanisms. Biochem J (2012) 1.51
Cancer inflammation and regulatory T cells. Int J Cancer (2010) 1.40
LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PLoS One (2011) 1.36
Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia (2008) 1.28
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The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis (2009) 1.16
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer (2009) 1.14
HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biol Ther (2008) 1.13
Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia (2010) 1.12
Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res (2008) 1.05
Transcription factor 7-like 2 polymorphism and colon cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.03
Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker. PLoS One (2011) 1.03
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Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. Carcinogenesis (2008) 0.97
Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. Pharm Res (2010) 0.95
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A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. PLoS One (2012) 0.93
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. PLoS One (2013) 0.90
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Analysis of APC and IGFBP7 promoter gene methylation in Swedish and Vietnamese colorectal cancer patients. Oncol Lett (2012) 0.89
The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer. Cell Biochem Funct (2012) 0.87
Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease. World J Surg (2008) 0.87
RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest (2014) 0.86
Wnt signaling in gut organogenesis. Organogenesis (2008) 0.86
Candidate serum biomarkers for early intestinal cancer using 15N metabolic labeling and quantitative proteomics in the ApcMin/+ mouse. J Proteome Res (2013) 0.86
Clock genes: their role in colorectal cancer. World J Gastroenterol (2014) 0.86
Targeting mTOR network in colorectal cancer therapy. World J Gastroenterol (2014) 0.86
p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression. J Biol Chem (2014) 0.85
Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. PLoS One (2012) 0.84
Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population. Hum Genomics (2011) 0.84
Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect. PLoS One (2014) 0.83
Expression and localization of axin 2 in colorectal carcinoma and its clinical implication. Int J Colorectal Dis (2013) 0.82
Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma risk. Eur J Cancer (2010) 0.82
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer Lett (2009) 0.82
Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating β-catenin/T cell factor activity. Oncotarget (2014) 0.81
Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC). RNA Biol (2011) 0.81
Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts. Mol Biol Cell (2016) 0.81
different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli. PLoS One (2014) 0.80
Evolution of network biomarkers from early to late stage bladder cancer samples. Biomed Res Int (2014) 0.80
Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes. Mamm Genome (2015) 0.80
Potential of casein kinase I in digestive cancer screening. World J Gastrointest Oncol (2009) 0.79
Expression of Indian hedgehog is negatively correlated with APC gene mutation in colorectal tumors. Int J Clin Exp Med (2014) 0.79
Selenium and inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol (2015) 0.79
Retained cell–cell adhesion in serrated neoplastic pathway as opposed to conventional colorectal adenomas. J Histochem Cytochem (2011) 0.78
LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway. Oncol Lett (2015) 0.78
Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep (2015) 0.77
Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background. Mol Carcinog (2009) 0.77
Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol (2011) 0.77
Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget (2016) 0.77
Methylation status of the APC and RASSF1A promoter in cell-free circulating DNA and its prognostic role in patients with colorectal cancer. Oncol Lett (2016) 0.77
The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary. J Oncol (2010) 0.76
Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy. Medchemcomm (2015) 0.76
Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer. Cancer Res (2016) 0.76
The genomics of colorectal cancer: state of the art. Curr Genomics (2008) 0.76
The Epigenomics of Embryonic Pathway Signaling in Colorectal Cancer. Front Pharmacol (2017) 0.76
Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation. Fam Cancer (2012) 0.75
Wnt pathway may not be implicated in all routes to colorectal cancer. Gut (2007) 0.75
The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells. Biomol Ther (Seoul) (2016) 0.75
Colorectal cancer risk genes are functionally enriched in regulatory pathways. Sci Rep (2016) 0.75
A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). Elife (2017) 0.75
Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway. Cancer Sci (2016) 0.75
Analysis of bacteria from intestinal tract of FAP patients for the presence of APC-like sequences. Med Sci Monit (2012) 0.75
Association of APC I1307K and E1317Q polymorphisms with colorectal cancer among Egyptian subjects. Fam Cancer (2016) 0.75
Tumor suppressor genes in familial adenomatous polyposis. Gastroenterol Hepatol Bed Bench (2017) 0.75
Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. PLoS Biol (2017) 0.75
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat Chem Biol (2017) 0.75
Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer. BMC Med Genet (2017) 0.75
TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy. Int J Mol Sci (2017) 0.75
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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature (2003) 6.09
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science (2005) 5.68
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Sticky business: orchestrating cellular signals at adherens junctions. Cell (2003) 4.91
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E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. Exp Cell Res (2006) 1.04
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Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. Hum Mol Genet (2006) 0.97
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Truncated APC is required for cell proliferation and DNA replication. Int J Cancer (2006) 0.93
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A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. PLoS One (2012) 0.93
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Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. PLoS One (2013) 0.90
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APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC. Hum Mol Genet (2011) 0.90
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Coordinated expression of cyclin D1 and LEF-1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma. Liver Int (2005) 0.89
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol (2009) 0.88
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Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. J Biol Chem (2012) 0.85
Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning. J Biol Chem (2011) 0.84
APC sensitive gastric acid secretion. Cell Physiol Biochem (2009) 0.84
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