Published in Protein Eng Des Sel on September 08, 2009
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Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39
Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A (2009) 2.35
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Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
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Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol (2006) 1.82
Phage display for engineering and analyzing protein interaction interfaces. Curr Opin Struct Biol (2007) 1.81
Helix, sheet, and polyproline II frequencies and strong nearest neighbor effects in a restricted coil library. Biochemistry (2005) 1.73
Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies. J Mol Biol (2008) 1.70
Differential receptor subunit affinities of type I interferons govern differential signal activation. J Mol Biol (2006) 1.67
USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response. PLoS One (2011) 1.60
Architecture of the fungal nuclear pore inner ring complex. Science (2015) 1.59
Specific and stable fluorescence labeling of histidine-tagged proteins for dissecting multi-protein complex formation. J Am Chem Soc (2006) 1.53
Synthetic antibodies for specific recognition and crystallization of structured RNA. Proc Natl Acad Sci U S A (2007) 1.51
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol (2010) 1.47
A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces. J Mol Biol (2008) 1.45
Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain. Methods Mol Biol (2007) 1.41
Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor. Proc Natl Acad Sci U S A (2002) 1.40
Design of protein function leaps by directed domain interface evolution. Proc Natl Acad Sci U S A (2008) 1.39
The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities. J Biol Chem (2008) 1.33
Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J Mol Biol (2011) 1.29
CDR-H3 diversity is not required for antigen recognition by synthetic antibodies. J Mol Biol (2012) 1.27
Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc Natl Acad Sci U S A (2013) 1.25
Thermodynamic and kinetic exploration of the energy landscape of Borrelia burgdorferi OspA by native-state hydrogen exchange. J Mol Biol (2002) 1.25
Cell-free production of G protein-coupled receptors for functional and structural studies. J Struct Biol (2007) 1.24
Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. J Mol Biol (2003) 1.24
Fluorescence microscopy assays on chemically functionalized surfaces for quantitative imaging of microtubule, motor, and +TIP dynamics. Methods Cell Biol (2010) 1.23
Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Sci (2008) 1.20
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol (2010) 1.18
Structural insights for engineering binding proteins based on non-antibody scaffolds. Curr Opin Struct Biol (2012) 1.18
Atomic structures of peptide self-assembly mimics. Proc Natl Acad Sci U S A (2006) 1.17
Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers. J Mol Biol (2004) 1.17
Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A (2011) 1.15
Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution. J Mol Biol (2009) 1.14
Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol (2007) 1.13
High-affinity labeling and tracking of individual histidine-tagged proteins in live cells using Ni2+ tris-nitrilotriacetic acid quantum dot conjugates. Nano Lett (2009) 1.13
Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar1. J Mol Biol (2005) 1.12
Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function. J Biol Chem (2006) 1.10
Ultrathin nucleoporin phenylalanine-glycine repeat films and their interaction with nuclear transport receptors. EMBO Rep (2010) 1.10
Atomic-resolution crystal structure of Borrelia burgdorferi outer surface protein A via surface engineering. Protein Sci (2006) 1.10
High-affinity chelator thiols for switchable and oriented immobilization of histidine-tagged proteins: a generic platform for protein chip technologies. Chemistry (2005) 1.10
Arginine- and lysine-specific polymers for protein recognition and immobilization. J Am Chem Soc (2006) 1.09
Conformational heterogeneity of an equilibrium folding intermediate quantified and mapped by scanning mutagenesis. J Mol Biol (2004) 1.08
Molecular recognition properties of FN3 monobodies that bind the Src SH3 domain. Chem Biol (2004) 1.08
Processive kinesins require loose mechanical coupling for efficient collective motility. EMBO Rep (2008) 1.07
Self-controlled monofunctionalization of quantum dots for multiplexed protein tracking in live cells. Angew Chem Int Ed Engl (2010) 1.07
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods (2012) 1.06
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proc Natl Acad Sci U S A (2012) 1.06
T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment. PLoS One (2012) 1.05
Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain. Protein Eng (2002) 1.05
Recombinant antibodies to histone post-translational modifications. Nat Methods (2013) 1.05
Covalent monofunctionalization of peptide-coated quantum dots for single-molecule assays. Nano Lett (2010) 1.05
A peptide tag system for facile purification and single-molecule immobilization. Biochemistry (2009) 1.05
Triple-color super-resolution imaging of live cells: resolving submicroscopic receptor organization in the plasma membrane. Angew Chem Int Ed Engl (2012) 1.04
Determination of the two-dimensional interaction rate constants of a cytokine receptor complex. Biophys J (2006) 1.04
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design. Proc Natl Acad Sci U S A (2011) 1.03
Conformation-specific affinity purification of proteins using engineered binding proteins: application to the estrogen receptor. Protein Expr Purif (2005) 1.03
Broad ranges of affinity and specificity of anti-histone antibodies revealed by a quantitative peptide immunoprecipitation assay. J Mol Biol (2012) 1.03
Binding modes of thioflavin-T to the single-layer beta-sheet of the peptide self-assembly mimics. J Mol Biol (2009) 1.03
Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain. J Mol Biol (2008) 1.02
The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling. J Mol Biol (2007) 0.99
Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection. Biophys J (2005) 0.99
Aromatic cross-strand ladders control the structure and stability of beta-rich peptide self-assembly mimics. J Mol Biol (2008) 0.99
Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism. Mol Cell Biol (2008) 0.98
Stable and functional immobilization of histidine-tagged proteins via multivalent chelator headgroups on a molecular poly(ethylene glycol) brush. Anal Chem (2005) 0.98
Native protein nanolithography that can write, read and erase. Nat Nanotechnol (2007) 0.97
The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes. J Cell Sci (2014) 0.96
In situ assembly of macromolecular complexes triggered by light. Proc Natl Acad Sci U S A (2010) 0.96
Noncovalent, site-specific biotinylation of histidine-tagged proteins. Anal Chem (2007) 0.96
Unfolding mechanics of multiple OspA substructures investigated with single molecule force spectroscopy. J Mol Biol (2003) 0.94
Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Curr Opin Struct Biol (2008) 0.94
Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc Natl Acad Sci U S A (2013) 0.94
Monitoring the dynamics of ligand-receptor complexes on model membranes. J Am Chem Soc (2006) 0.93
Substrates for cell adhesion prepared via active site-directed immobilization of a protein domain. Langmuir (2004) 0.93
Four-color single-molecule fluorescence with noncovalent dye labeling to monitor dynamic multimolecular complexes. Biotechniques (2010) 0.92
A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc Natl Acad Sci U S A (2009) 0.91
Identification of regions within the F domain of the human estrogen receptor alpha that are important for modulating transactivation and protein-protein interactions. Mol Endocrinol (2006) 0.91
Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One (2009) 0.91
Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation. J Biol Chem (2003) 0.90
Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc Natl Acad Sci U S A (2013) 0.90
High-affinity fragment complementation of a fibronectin type III domain and its application to stability enhancement. Protein Sci (2005) 0.89
TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres. Nucleic Acids Res (2013) 0.89
Nanoscale organization of mitochondrial microcompartments revealed by combining tracking and localization microscopy. Nano Lett (2012) 0.88
Hydrophobic surface burial is the major stability determinant of a flat, single-layer beta-sheet. J Mol Biol (2007) 0.88
Functional immobilization and patterning of proteins by an enzymatic transfer reaction. Anal Chem (2010) 0.87
Backbone dynamics and thermodynamics of Borrelia outer surface protein A. J Mol Biol (2002) 0.87
High-throughput analysis of the protein sequence-stability landscape using a quantitative yeast surface two-hybrid system and fragment reconstitution. J Mol Biol (2008) 0.87