Published in Proc Natl Acad Sci U S A on December 27, 2007
Beyond natural antibodies: the power of in vitro display technologies. Nat Biotechnol (2011) 2.41
Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A (2009) 2.35
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. ACS Chem Biol (2009) 1.65
A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. Nat Chem Biol (2014) 1.64
Improving small-angle X-ray scattering data for structural analyses of the RNA world. RNA (2010) 1.60
Engineering of recombinant crystallization chaperones. Curr Opin Struct Biol (2009) 1.53
Application of protein engineering to enhance crystallizability and improve crystal properties. Acta Crystallogr D Biol Crystallogr (2010) 1.38
Engineering RNA for targeted siRNA delivery and medical application. Adv Drug Deliv Rev (2010) 1.32
Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science (2009) 1.27
Fabs enable single particle cryoEM studies of small proteins. Structure (2012) 1.25
Structural DNA nanotechnology: state of the art and future perspective. J Am Chem Soc (2014) 1.25
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat Struct Mol Biol (2011) 1.23
An enumerative stepwise ansatz enables atomic-accuracy RNA loop modeling. Proc Natl Acad Sci U S A (2011) 1.21
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol (2010) 1.18
Identification of catalytic metal ion ligands in ribozymes. Methods (2009) 1.18
Use of the spliceosomal protein U1A to facilitate crystallization and structure determination of complex RNAs. Methods (2010) 1.13
Unwinding RNA's secrets: advances in the biology, physics, and modeling of complex RNAs. Curr Opin Struct Biol (2008) 1.10
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods (2012) 1.06
Engineering RNA-binding proteins for biology. FEBS J (2013) 1.06
An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proc Natl Acad Sci U S A (2009) 1.04
Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev. J Mol Biol (2010) 1.00
A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Mol Cell Proteomics (2015) 0.97
Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein. Chembiochem (2012) 0.97
Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system. Nucleic Acids Res (2010) 0.95
A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P. J Mol Biol (2010) 0.89
New molecular engineering approaches for crystallographic studies of large RNAs. Curr Opin Struct Biol (2014) 0.87
RNA structural motifs that entail hydrogen bonds involving sugar-phosphate backbone atoms of RNA. New J Chem (2010) 0.82
2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA. Chem Biol (2011) 0.81
Deep sequencing in library selection projects: what insight does it bring? Curr Opin Struct Biol (2015) 0.80
Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies. Nucleic Acids Res (2009) 0.80
Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment. Philos Trans R Soc Lond B Biol Sci (2011) 0.80
Improvement of the crystallizability and expression of an RNA crystallization chaperone. J Biochem (2011) 0.79
A strategy for phage display selection of functional domain-exchanged immunoglobulin scaffolds with high affinity for glycan targets. J Immunol Methods (2011) 0.79
Biocrystallography: past, present, future. HFSP J (2010) 0.78
NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proc Natl Acad Sci U S A (2010) 0.78
m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs. Nat Struct Mol Biol (2016) 0.77
Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments. J Immunol Methods (2014) 0.76
Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display. Protein Sci (2015) 0.76
RNA recognition by a human antibody against brain cytoplasmic 200 RNA. RNA (2014) 0.76
Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator. MAbs (2016) 0.75
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment. J Mol Biol (2016) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Global identification of human transcribed sequences with genome tiling arrays. Science (2004) 17.85
Principles of protein-protein interactions. Proc Natl Acad Sci U S A (1996) 14.51
The fluorescent toolbox for assessing protein location and function. Science (2006) 14.02
Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (1996) 13.99
Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis. J Mol Biol (1990) 10.85
Crystal structure of a hepatitis delta virus ribozyme. Nature (1998) 7.07
Regulation of bacterial gene expression by riboswitches. Annu Rev Microbiol (2005) 5.66
Potent antibody therapeutics by design. Nat Rev Immunol (2006) 4.87
Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis. Nature (2001) 4.59
Crystal structure of a self-splicing group I intron with both exons. Nature (2004) 3.92
The chemical repertoire of natural ribozymes. Nature (2002) 3.77
Interactions of protein antigens with antibodies. Proc Natl Acad Sci U S A (1996) 3.53
Antibody targeted drugs as cancer therapeutics. Nat Rev Drug Discov (2006) 3.08
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J Mol Biol (2007) 2.88
Phage display for selection of novel binding peptides. Methods Enzymol (2000) 2.78
Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol Cell (2004) 2.68
An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme. Biochemistry (1993) 2.58
Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure (2001) 2.49
High-affinity single-domain binding proteins with a binary-code interface. Proc Natl Acad Sci U S A (2007) 2.18
Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proc Natl Acad Sci U S A (2004) 2.17
High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold. J Mol Biol (2004) 2.14
Length distribution of CDRH3 in antibodies. Proteins (1993) 2.12
Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. J Mol Biol (2000) 2.09
Relationship between ion pair geometries and electrostatic strengths in proteins. Biophys J (2002) 1.91
Molecular recognition by a binary code. J Mol Biol (2005) 1.85
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains. Ann N Y Acad Sci (1971) 1.84
Statistical analysis of atomic contacts at RNA-protein interfaces. J Mol Recognit (2001) 1.73
Multiplexed sandwich assays in microarray format. J Immunol Methods (2004) 1.60
X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. J Mol Biol (1993) 1.52
Crystallisation of membrane proteins mediated by antibody fragments. Curr Opin Struct Biol (2002) 1.50
Protein-nucleic acid recognition: statistical analysis of atomic interactions and influence of DNA structure. Proteins (2005) 1.46
Linkage of monovalent and divalent ion binding in the folding of the P4-P6 domain of the Tetrahymena ribozyme. Biochemistry (2002) 1.31
Polysaccharide vaccines as probes of antibody repertoires in man. Immunol Rev (1999) 1.26
Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code. J Mol Biol (2005) 1.26
The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins. Nat Struct Mol Biol (2006) 1.26
Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases. J Clin Invest (1990) 1.11
Preparation, characterization and crystallization of an antibody Fab fragment that recognizes RNA. Crystal structures of native Fab and three Fab-mononucleotide complexes. J Mol Biol (1994) 0.99
In vitro genetic analysis of RNA-binding proteins using phage display libraries. Methods Enzymol (1996) 0.98
Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs. Proc Natl Acad Sci U S A (1993) 0.98
Conserved sequence and structure association motifs in antibody-protein and antibody-hapten complexes. Protein Eng Des Sel (2004) 0.97
Discovering the interaction propensities of amino acids and nucleotides from protein-RNA complexes. Mol Cells (2003) 0.96
Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud's phenomenon and polyarthritis. Clin Rheumatol (1998) 0.82
Antibodies against double-stranded RNA in patients with rheumatoid arthritis, osteoarthrosis and Paget's disease of bone. Aust N Z J Med (1981) 0.80
The immunogenic properties of poly(dI).poly(dC) and poly(rI). poly(dC)--analysis by monoclonal antibodies. Mol Immunol (1986) 0.79
Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell (2008) 5.37
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
General acid catalysis by the hepatitis delta virus ribozyme. Nat Chem Biol (2005) 2.88
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. J Mol Biol (2007) 2.88
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A (2006) 2.66
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A (2009) 2.35
Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta (2010) 2.22
High-affinity single-domain binding proteins with a binary-code interface. Proc Natl Acad Sci U S A (2007) 2.18
Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell (2008) 2.18
Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proc Natl Acad Sci U S A (2004) 2.17
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14
High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold. J Mol Biol (2004) 2.14
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity (2010) 2.02
Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (2012) 1.92
RNA catalyses nuclear pre-mRNA splicing. Nature (2013) 1.86
Molecular recognition by a binary code. J Mol Biol (2005) 1.85
Rapid evolution of functional complexity in a domain family. Sci Signal (2009) 1.85
Phage display for engineering and analyzing protein interaction interfaces. Curr Opin Struct Biol (2007) 1.81
Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. PLoS Biol (2009) 1.78
Helix, sheet, and polyproline II frequencies and strong nearest neighbor effects in a restricted coil library. Biochemistry (2005) 1.73
Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies. J Mol Biol (2008) 1.70
Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nat Chem Biol (2006) 1.68
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine. Nucleic Acids Res (2007) 1.66
Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol (2009) 1.65
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. ACS Chem Biol (2009) 1.65
X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. J Am Chem Soc (2008) 1.64
The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem (2002) 1.59
Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. J Biol Chem (2006) 1.59
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. Structure (2003) 1.56
Structural inference of native and partially folded RNA by high-throughput contact mapping. Proc Natl Acad Sci U S A (2008) 1.54
Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions. J Mol Biol (2004) 1.53
New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis. Chem Biol (2004) 1.53
Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families. J Biol Chem (2006) 1.49
Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain. J Biol Chem (2002) 1.49
Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries. Nat Protoc (2007) 1.49
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol (2010) 1.47
A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces. J Mol Biol (2008) 1.45
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. J Biol Chem (2006) 1.43
Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain. Methods Mol Biol (2007) 1.41
The intrinsic contributions of tyrosine, serine, glycine and arginine to the affinity and specificity of antibodies. J Mol Biol (2008) 1.41
Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor. Proc Natl Acad Sci U S A (2002) 1.40
Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A (2009) 1.40
Design of protein function leaps by directed domain interface evolution. Proc Natl Acad Sci U S A (2008) 1.39
Synthetic therapeutic antibodies. Nat Chem Biol (2006) 1.39
Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing. Mol Biosyst (2010) 1.35
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. Biochem J (2010) 1.34
Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis. J Mol Biol (2002) 1.33
Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3. Protein Sci (2007) 1.31
Bivalent antibody phage display mimics natural immunoglobulin. J Immunol Methods (2004) 1.30
Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J Mol Biol (2011) 1.29
Definition of the consensus motif recognized by gamma-adaptin ear domains. J Biol Chem (2003) 1.29
Target-binding proteins based on the 10th human fibronectin type III domain (¹⁰Fn3). Methods Enzymol (2012) 1.29
A second divalent metal ion in the group II intron reaction center. Chem Biol (2007) 1.29
Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science (2009) 1.27
CDR-H3 diversity is not required for antigen recognition by synthetic antibodies. J Mol Biol (2012) 1.27
Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains. J Biol Chem (2007) 1.26
Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code. J Mol Biol (2005) 1.26
The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins. Nat Struct Mol Biol (2006) 1.26
Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc Natl Acad Sci U S A (2013) 1.25
Thermodynamic and kinetic exploration of the energy landscape of Borrelia burgdorferi OspA by native-state hydrogen exchange. J Mol Biol (2002) 1.25
Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. J Mol Biol (2003) 1.24
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat Struct Mol Biol (2011) 1.23
The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. Mol Cell (2010) 1.23
Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci (2009) 1.20
Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Sci (2008) 1.20
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol (2010) 1.18