Published in Proc Am Thorac Soc on September 15, 2009
Respiratory impairment and the aging lung: a novel paradigm for assessing pulmonary function. J Gerontol A Biol Sci Med Sci (2011) 1.28
Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest (2011) 1.17
Chronic obstructive pulmonary disease: lobe-based visual assessment of volumetric CT by Using standard images--comparison with quantitative CT and pulmonary function test in the COPDGene study. Radiology (2012) 1.07
Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease. Dis Model Mech (2014) 1.02
Histone 3.3 participates in a self-sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 0.97
Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation? PLoS One (2013) 0.97
Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition. Br J Pharmacol (2012) 0.95
CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-α and IL-6 and promote cigarette smoke-induced emphysema. J Immunol (2011) 0.93
Inflammation and immune response in COPD: where do we stand? Mediators Inflamm (2013) 0.92
Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema. Front Physiol (2013) 0.90
RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease. Front Physiol (2012) 0.90
Proteostasis: a new therapeutic paradigm for pulmonary disease. Proc Am Thorac Soc (2011) 0.86
The axonal guidance cue semaphorin 3C contributes to alveolar growth and repair. PLoS One (2013) 0.86
Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages. Cell Death Dis (2011) 0.86
Neutrophil elastase inhibitors. Expert Opin Ther Pat (2011) 0.85
Protein Arginine Methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders. Int J Mol Sci (2012) 0.82
Association of polymorphisms of the receptor for advanced glycation end products gene with COPD in the Chinese population. DNA Cell Biol (2014) 0.80
Immune Dysfunction in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2015) 0.80
Resolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol (2015) 0.80
Next-generation personalized drug discovery: the tripeptide GHK hits center stage in chronic obstructive pulmonary disease. Genome Med (2012) 0.76
NLRP3 inflammasome is essential for the development of chronic obstructive pulmonary disease. Int J Clin Exp Pathol (2015) 0.76
Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold. Eur J Med Chem (2010) 0.76
Identification of Novel Therapeutic Targets in COPD. Tanaffos (2011) 0.76
Association of Functional Variants of Phase I and II Genes with Chronic Obstructive Pulmonary Disease in a Serbian Population. J Med Biochem (2015) 0.75
Dual function inhibitors of relevance to chronic obstructive pulmonary disease. Bioorg Med Chem Lett (2010) 0.75
Association between glutathione S-transferase P1 Ile (105) Val gene polymorphism and chronic obstructive pulmonary disease: A meta-analysis based on seventeen case-control studies. Meta Gene (2015) 0.75
Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Tiotropium Attenuates Virus-Induced Pulmonary Inflammation in Cigarette Smoke-Exposed Mice. J Pharmacol Exp Ther (2016) 0.75
Computational modeling helps uncover mechanisms related to the progression of emphysema. Drug Discov Today Dis Models (2014) 0.75
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase. Bioorg Med Chem (2010) 0.75
Awareness in patients with COPD about the disease and pulmonary rehabilitation: A survey. Lung India (2014) 0.75
Cigarette Smoke and DNA Cleavage Promote Lung Inflammation and Emphysema. Trans Am Clin Climatol Assoc (2017) 0.75
CT Quantification of Lungs and Airways in Normal Korean Subjects. Korean J Radiol (2017) 0.75
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96
Chronic obstructive pulmonary disease in non-smokers. Lancet (2009) 6.41
Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med (2005) 6.13
Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008. Am J Respir Crit Care Med (2011) 3.33
Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest (2002) 3.05
Isoprostanes: markers and mediators of oxidative stress. FASEB J (2004) 2.83
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med (2005) 2.72
Retracted The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med (2006) 2.72
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med (2009) 2.56
COPD as a disease of accelerated lung aging. Chest (2009) 2.56
Chronic obstructive pulmonary disease mortality and prevalence: the associations with smoking and poverty--a BOLD analysis. Thorax (2013) 2.52
The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest (2003) 2.44
Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med (2005) 2.43
Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med (2002) 2.40
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med (2004) 2.19
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A (2002) 2.17
Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16
Appropriateness of newborn screening for α1-antitrypsin deficiency. J Pediatr Gastroenterol Nutr (2014) 2.10
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 2.06
Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 2.06
Molecular mechanisms of corticosteroid resistance. Chest (2008) 2.06
Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest (2003) 2.04
The European Respiratory Society plans its future: the 2013-2018 strategic plan. Eur Respir J (2014) 2.02
Reduction in asthma-related emergency department visits after implementation of a smoke-free law. J Allergy Clin Immunol (2008) 2.02
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 2.02
Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2002) 2.00
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med (2005) 1.93
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol (2002) 1.84
Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly. Chest (2005) 1.84
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 1.84
Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 1.82
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol (2004) 1.77
Glucocorticoids: effects on gene transcription. Proc Am Thorac Soc (2004) 1.73
Is exposure to biomass smoke the biggest risk factor for COPD globally? Chest (2010) 1.71
p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol (2011) 1.70
Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control. Chest (2008) 1.67
Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.67
COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention. COPD (2008) 1.65
Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care Med (2002) 1.65
Wildland forest fire smoke: health effects and intervention evaluation, Hoopa, California, 1999. West J Med (2002) 1.64
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med (2009) 1.59
Chronic idiopathic cough: a discrete clinical entity? Chest (2005) 1.59
Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology (2003) 1.57
Maternally imprinted microRNAs are differentially expressed during mouse and human lung development. Dev Dyn (2007) 1.57
Treatment of airway mucus hypersecretion. Ann Med (2006) 1.55
Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am J Respir Crit Care Med (2002) 1.54
Prevalence and correlates of restless legs syndrome: results from the 2005 National Sleep Foundation Poll. Chest (2006) 1.53
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol (2002) 1.53
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med (2004) 1.53
Rescue treatment in asthma. More than as-needed bronchodilation. Chest (2009) 1.52
Comparison of the effects of salmeterol and formoterol in patients with severe asthma. Chest (2002) 1.50
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J (2009) 1.47
Racial and ethnic disparities in asthma medication usage and health-care utilization: data from the National Asthma Survey. Chest (2009) 1.47
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol (2006) 1.46
Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers (2002) 1.45
Correlates of sleep complaints in adults: the ARIC study. J Clin Sleep Med (2005) 1.40
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol (2004) 1.38
Oxidative stress in COPD. Chest (2013) 1.37
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med (2006) 1.37
Exhaled biomarkers. Chest (2006) 1.36
The role of oxidative stress in chronic obstructive pulmonary disease. COPD (2004) 1.33
Against the Dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases. Am J Respir Crit Care Med (2006) 1.32
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol (2007) 1.28
Chronic obstructive pulmonary disease and lung cancer: new molecular insights. Respiration (2011) 1.28
Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids. Chest (2002) 1.27
Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med (2002) 1.27
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J (2003) 1.27
Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am J Respir Cell Mol Biol (2008) 1.23
The electronic nose in respiratory medicine. Respiration (2012) 1.23
Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease. Thorax (2012) 1.23
CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest (2007) 1.22
Analysis of expired air for oxidation products. Am J Respir Crit Care Med (2002) 1.22
Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice. Blood (2003) 1.21
Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease. Thorax (2010) 1.18
Recent trends in exposure to secondhand smoke in the United States population. BMC Public Health (2010) 1.18
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun (2011) 1.18
Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD (2005) 1.17
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol (2005) 1.17
Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase. J Allergy Clin Immunol (2010) 1.17
Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases. Br J Pharmacol (2002) 1.17
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun (2009) 1.17
Analysis of exhaled breath condensate for monitoring airway inflammation. Trends Pharmacol Sci (2002) 1.16
Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol (2006) 1.15
Theobromine inhibits sensory nerve activation and cough. FASEB J (2004) 1.15
Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol (2002) 1.14
Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.13
New drugs for exacerbations of chronic obstructive pulmonary disease. Lancet (2009) 1.13
Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis. Am J Respir Crit Care Med (2003) 1.13
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther (2007) 1.11
Acidic mammalian chitinase--a potential target for asthma therapy. Trends Pharmacol Sci (2004) 1.11
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. PLoS One (2011) 1.10
Beta2-agonists potentiate corticosteroid-induced neutrophil survival. COPD (2008) 1.10
Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. J Leukoc Biol (2004) 1.09
Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest (2010) 1.08
High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. Respir Med (2003) 1.08
Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J Allergy Clin Immunol (2004) 1.07