Published in Trans Am Clin Climatol Assoc on January 01, 2017
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 35.41
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
IL-17 and Th17 Cells. Annu Rev Immunol (2009) 23.02
The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med (2004) 17.08
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19
50-year trends in smoking-related mortality in the United States. N Engl J Med (2013) 7.80
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet (2004) 5.16
Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med (2009) 4.27
Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med (1974) 3.88
Smoking vs other risk factors as the cause of smoking-attributable deaths: confounding in the courtroom. JAMA (2000) 3.21
An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med (2004) 3.12
Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med (2007) 3.05
The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am J Respir Crit Care Med (2004) 2.94
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol (2003) 2.66
The relationship between lung inflammation and cardiovascular disease. Am J Respir Crit Care Med (2012) 2.54
TH17 cells in asthma and COPD. Annu Rev Physiol (2010) 2.36
Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med (2000) 2.36
Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med (2003) 2.26
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema. Nat Immunol (2015) 2.13
CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol (2007) 1.92
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol (2009) 1.89
Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest (2004) 1.88
Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation. J Clin Invest (1984) 1.72
Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur Respir J (2001) 1.68
Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med (2009) 1.61
Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma. Am J Respir Crit Care Med (1999) 1.56
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med (2012) 1.54
Clinical and Immunological Factors in Emphysema Progression. Five-Year Prospective Longitudinal Exacerbation Study of Chronic Obstructive Pulmonary Disease (LES-COPD). Am J Respir Crit Care Med (2015) 1.50
Pathogenesis of chronic obstructive pulmonary disease. Clin Chest Med (2007) 1.34
Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med (2013) 1.34
Burden and pathogenesis of chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 1.28
Elastin and the lung. Thorax (1986) 1.24
Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors. J Clin Invest (1984) 1.16
Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett (2008) 1.14
Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. Expert Rev Clin Immunol (2012) 1.07
'Black Spots' and hyaline pleural plaques on the parietal pleura of 150 urban necropsy cases. Am J Surg Pathol (2002) 1.07
Persistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 years. Chest (2010) 1.05
Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema. J Clin Invest (2014) 0.97
Autoreactive T Cells in Human Smokers is Predictive of Clinical Outcome. Front Immunol (2012) 0.96
DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation. Semin Cancer Biol (2016) 0.95
Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. Elife (2015) 0.94
Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers. Int J Environ Res Public Health (2011) 0.93
Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease. Eur Respir J (2007) 0.93
Immunologic measurement of elastin-derived peptides in human serum. Am Rev Respir Dis (1983) 0.90
Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol (2012) 0.86
Effects of 4 months of smoking in mice with ovalbumin-induced airway inflammation. Clin Exp Allergy (2007) 0.86
Impact of cigarette smoking in high-risk patients participating in a clinical trial. A substudy from the Heart Outcomes Prevention Evaluation (HOPE) trial. Eur J Cardiovasc Prev Rehabil (2005) 0.81
Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer. Clin Transl Med (2016) 0.79
The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema. Exp Lung Res (1989) 0.79
Cigarette smoke inhalation potentiates elastase-induced emphysema in hamsters. Am Rev Respir Dis (1983) 0.78
COPD in 2016: some answers, more questions. Lancet Respir Med (2016) 0.76
Long-term trends in cardiovascular disease mortality and association with respiratory disease. Epidemiol Infect (2015) 0.76
Loss of Peripheral Tolerance in Emphysema. Phenotypes, Exacerbations, and Disease Progression. Ann Am Thorac Soc (2015) 0.75