Published in Structure on September 09, 2009
The S helix mediates signal transmission as a HAMP domain coiled-coil extension in the NarX nitrate sensor from Escherichia coli K-12. J Bacteriol (2009) 1.10
Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol (2015) 1.10
A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system. Proc Natl Acad Sci U S A (2012) 1.07
An asymmetry-to-symmetry switch in signal transmission by the histidine kinase receptor for TMAO. Structure (2012) 1.07
Transmembrane helix dynamics of bacterial chemoreceptors supports a piston model of signalling. PLoS Comput Biol (2011) 1.02
Activated chemoreceptor arrays remain intact and hexagonally packed. Mol Microbiol (2011) 1.00
Structure and proposed mechanism for the pH-sensing Helicobacter pylori chemoreceptor TlpB. Structure (2012) 1.00
Signal transduction in histidine kinases: insights from new structures. Structure (2015) 0.95
Mechanism of bacterial signal transduction revealed by molecular dynamics of Tsr dimers and trimers of dimers in lipid vesicles. PLoS Comput Biol (2012) 0.92
Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling. J Biol Chem (2011) 0.89
Molecular Mechanisms of Two-Component Signal Transduction. J Mol Biol (2016) 0.87
Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ. Proc Natl Acad Sci U S A (2010) 0.87
Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges. Curr Opin Struct Biol (2014) 0.86
Structural basis for cytokinin receptor signaling: an evolutionary approach. Plant Cell Rep (2013) 0.83
Two distinct states of the HAMP domain from sensory rhodopsin transducer observed in unbiased molecular dynamics simulations. PLoS One (2013) 0.82
The role of membrane-mediated interactions in the assembly and architecture of chemoreceptor lattices. PLoS Comput Biol (2014) 0.81
Structural characterization of AS1-membrane interactions from a subset of HAMP domains. Biochim Biophys Acta (2011) 0.78
Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues. Biochim Biophys Acta (2014) 0.77
Transmembrane signaling in the sensor kinase DcuS of Escherichia coli: A long-range piston-type displacement of transmembrane helix 2. Proc Natl Acad Sci U S A (2015) 0.76
Evidence for a Helix-Clutch Mechanism of Transmembrane Signaling in a Bacterial Chemoreceptor. J Mol Biol (2016) 0.76
The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils. Application to understand signaling in histidine kinases. Protein Sci (2016) 0.75
Employing aromatic tuning to modulate output from two-component signaling circuits. J Biol Eng (2015) 0.75
Bacterial chemoreceptors: high-performance signaling in networked arrays. Trends Biochem Sci (2007) 5.28
The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annu Rev Cell Dev Biol (1997) 4.99
Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand. Science (1991) 4.71
Transmembrane signaling in bacterial chemoreceptors. Trends Biochem Sci (2001) 4.69
A piston model for transmembrane signaling of the aspartate receptor. Science (1999) 3.42
Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein. EMBO J (2005) 2.85
Molecular mechanism of transmembrane signaling by the aspartate receptor: a model. Proc Natl Acad Sci U S A (1996) 2.74
Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface. Biochemistry (1995) 2.12
Sensor complexes regulating two-component signal transduction. Curr Opin Struct Biol (2007) 1.82
Detecting the conformational change of transmembrane signaling in a bacterial chemoreceptor by measuring effects on disulfide cross-linking in vivo. Proc Natl Acad Sci U S A (1996) 1.63
Structural analysis of ligand stimulation of the histidine kinase NarX. Structure (2009) 1.59
Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor. Biochemistry (2004) 1.49
The core signaling proteins of bacterial chemotaxis assemble to form an ultrastable complex. Biochemistry (2009) 1.46
A NarX-Tar chimera mediates repellent chemotaxis to nitrate and nitrite. Mol Microbiol (2002) 1.37
Tryptophan residues flanking the second transmembrane helix (TM2) set the signaling state of the Tar chemoreceptor. Biochemistry (2005) 1.32
Structural analysis of sensor domains from the TMAO-responsive histidine kinase receptor TorS. Structure (2009) 1.16
Bacterial chemoreceptors: high-performance signaling in networked arrays. Trends Biochem Sci (2007) 5.28
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages. Proc Natl Acad Sci U S A (2007) 1.81
Structure of the conserved HAMP domain in an intact, membrane-bound chemoreceptor: a disulfide mapping study. Biochemistry (2007) 1.80
Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis. Methods Enzymol (2007) 1.58
Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling. Biochemistry (2002) 1.57
Mechanics of Hsp70 chaperones enables differential interaction with client proteins. Nat Struct Mol Biol (2011) 1.54
Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor. Biochemistry (2009) 1.51
Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity. Biochemistry (2005) 1.51
Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor. Biochemistry (2004) 1.49
CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites. Biochemistry (2006) 1.49
GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid. Biochemistry (2004) 1.48
Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. Mol Biol Cell (2005) 1.47
The core signaling proteins of bacterial chemotaxis assemble to form an ultrastable complex. Biochemistry (2009) 1.46
Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching. Biochemistry (2005) 1.44
Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction. Biophys J (2009) 1.44
Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity. Biochemistry (2007) 1.42
C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling. Biochemistry (2003) 1.40
C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state. Biochemistry (2002) 1.39
Quantitative analysis of aspartate receptor signaling complex reveals that the homogeneous two-state model is inadequate: development of a heterogeneous two-state model. J Mol Biol (2003) 1.38
Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics. Biophys J (2010) 1.35
Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain. Biochemistry (2008) 1.30
Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling. Biochemistry (2003) 1.28
Use of EPR power saturation to analyze the membrane-docking geometries of peripheral proteins: applications to C2 domains. Annu Rev Biophys Biomol Struct (2005) 1.23
Mapping out regions on the surface of the aspartate receptor that are essential for kinase activation. Biochemistry (2003) 1.17
Evidence that the adaptation region of the aspartate receptor is a dynamic four-helix bundle: cysteine and disulfide scanning studies. Biochemistry (2005) 1.15
Self-induced docking site of a deeply embedded peripheral membrane protein. Biophys J (2006) 1.14
Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study. Biochemistry (2008) 1.07
Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study. J Mol Biol (2010) 1.06
The 3.2 Å resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays. Biochemistry (2013) 1.05
Chemotaxis receptor complexes: from signaling to assembly. PLoS Comput Biol (2007) 1.04
The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis. Methods Enzymol (2007) 0.95
Use of fluorescence resonance energy transfer to monitor Ca(2+)-triggered membrane docking of C2 domains. Methods Mol Biol (2002) 0.95
New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry (2014) 0.94
Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study. Biochemistry (2013) 0.94
Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core. Chem Phys Lipids (2013) 0.93
The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry (2011) 0.93
Thermal domain motions of CheA kinase in solution: Disulfide trapping reveals the motional constraints leading to trans-autophosphorylation. Biochemistry (2009) 0.92
Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion. Biochemistry (2012) 0.90
Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order. Biochemistry (2012) 0.89
Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α. Biochemistry (2014) 0.88
Molecular mechanism of membrane binding of the GRP1 PH domain. J Mol Biol (2013) 0.87
Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity. Biochemistry (2004) 0.86
Chemotaxis receptors and signaling. Adv Protein Chem (2004) 0.85
Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study. Biochemistry (2013) 0.84
Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study. PLoS One (2012) 0.84
Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7. Biochemistry (2012) 0.82
Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts. Biochemistry (2014) 0.81
Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study. J Am Chem Soc (2014) 0.80
The PH domain of phosphoinositide-dependent kinase-1 exhibits a novel, phospho-regulated monomer-dimer equilibrium with important implications for kinase domain activation: single-molecule and ensemble studies. Biochemistry (2013) 0.80
Cation charge and size selectivity of the C2 domain of cytosolic phospholipase A(2). Biochemistry (2002) 0.78
A radical intermediate in the conversion of pentachlorophenol to tetrachlorohydroquinone by Sphingobium chlorophenolicum. Biochemistry (2014) 0.76
OS-FRET: a new one-sample method for improved FRET measurements. Biochemistry (2010) 0.76
Reprint of: Purification of Proteins Using Polyhistidine Affinity Tags. Protein Expr Purif (2011) 0.75