Published in BioData Min on September 22, 2009
Bioinformatics challenges for genome-wide association studies. Bioinformatics (2010) 4.45
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics (2011) 1.68
Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine. Genes Immun (2010) 1.30
Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor. BMC Med Genet (2010) 0.99
Predicting the difficulty of pure, strict, epistatic models: metrics for simulated model selection. BioData Min (2012) 0.98
Analysis pipeline for the epistasis search - statistical versus biological filtering. Front Genet (2014) 0.96
Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. BMC Med Genomics (2012) 0.94
HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One (2012) 0.88
Systems analysis of high-throughput data. Adv Exp Med Biol (2014) 0.87
Multifactor dimensionality reduction reveals a three-locus epistatic interaction associated with susceptibility to pulmonary tuberculosis. BioData Min (2013) 0.87
A genetic ensemble approach for gene-gene interaction identification. BMC Bioinformatics (2010) 0.84
The application of network label propagation to rank biomarkers in genome-wide Alzheimer's data. BMC Genomics (2014) 0.84
Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis. Curr Pharmacogenomics Person Med (2011) 0.82
Detecting gene-gene interactions using a permutation-based random forest method. BioData Min (2016) 0.81
Application of a spatially-weighted Relief algorithm for ranking genetic predictors of disease. BioData Min (2012) 0.81
ReliefSeq: a gene-wise adaptive-K nearest-neighbor feature selection tool for finding gene-gene interactions and main effects in mRNA-Seq gene expression data. PLoS One (2013) 0.81
Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age. J Matern Fetal Neonatal Med (2010) 0.81
Practical aspects of genome-wide association interaction analysis. Hum Genet (2014) 0.79
Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes. BioData Min (2012) 0.79
Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network. BioData Min (2016) 0.77
A survey about methods dedicated to epistasis detection. Front Genet (2015) 0.77
The genetic interacting landscape of 63 candidate genes in Major Depressive Disorder: an explorative study. BioData Min (2014) 0.77
Genome-wide genetic interaction analysis of glaucoma using expert knowledge derived from human phenotype networks. Pac Symp Biocomput (2015) 0.76
Trachoma and Ocular Chlamydial Infection in the Era of Genomics. Mediators Inflamm (2015) 0.76
Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent. Genes Immun (2013) 0.76
A global test for gene-gene interactions based on random matrix theory. Genet Epidemiol (2016) 0.75
ExSTraCS 2.0: Description and Evaluation of a Scalable Learning Classifier System. Evol Intell (2015) 0.75
Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. J Ophthalmol (2015) 0.75
Machine learning and systems genomics approaches for multi-omics data. Biomark Res (2017) 0.75
Identification of interactions using model-based multifactor dimensionality reduction. BMC Proc (2016) 0.75
Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population. Ann Hum Genet (2016) 0.75
An empirical fuzzy multifactor dimensionality reduction method for detecting gene-gene interactions. BMC Genomics (2017) 0.75
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
A comprehensive review of genetic association studies. Genet Med (2002) 16.75
Genomewide association studies and human disease. N Engl J Med (2009) 9.05
The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered (2003) 7.42
Genetic risk prediction--are we there yet? N Engl J Med (2009) 7.30
A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J Theor Biol (2006) 6.22
Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. PLoS Genet (2009) 4.22
What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet (2008) 2.35
STUDENTJAMA. The challenges of whole-genome approaches to common diseases. JAMA (2004) 1.95
Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis. PLoS Genet (2009) 1.91
Shadows of complexity: what biological networks reveal about epistasis and pleiotropy. Bioessays (2009) 1.82
Evaporative cooling feature selection for genotypic data involving interactions. Bioinformatics (2007) 1.41
Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients. Arthritis Rheum (2008) 1.09
The future of genetic association studies in Alzheimer disease. J Neural Transm (Vienna) (2003) 0.88
Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks. Proc IEEE Symp Comput Intell Bioinforma Comput Biol (2007) 0.85
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
The genetic structure and history of Africans and African Americans. Science (2009) 10.65
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res (2007) 6.57
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol (2003) 6.31
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet (2003) 4.01
Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet (2004) 3.35
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. Neuroimage (2010) 3.27
Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation (2004) 3.02
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat Genet (2012) 2.86
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement (2010) 2.79
Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One (2009) 2.72
A global view of epistasis. Nat Genet (2005) 2.71
Machine learning for detecting gene-gene interactions: a review. Appl Bioinformatics (2006) 2.56
Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases. BMC Bioinformatics (2003) 2.47
Chapter 11: Genome-wide association studies. PLoS Comput Biol (2012) 2.46
Epigenomic enhancer profiling defines a signature of colon cancer. Science (2012) 2.15
Genetic basis for adverse events after smallpox vaccination. J Infect Dis (2008) 2.09
Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis (2005) 2.08
Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry. Cancer Res (2005) 2.06
Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet (2006) 1.97
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics (2004) 1.95
Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet (2012) 1.86
Multilocus analysis of hypertension: a hierarchical approach. Hum Hered (2004) 1.82
Shadows of complexity: what biological networks reveal about epistasis and pleiotropy. Bioessays (2009) 1.82
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Ideal discrimination of discrete clinical endpoints using multilocus genotypes. In Silico Biol (2004) 1.81
Recurrent tissue-specific mtDNA mutations are common in humans. PLoS Genet (2013) 1.77
No-boundary thinking in bioinformatics research. BioData Min (2013) 1.76
Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS. Bioinformatics (2010) 1.76
A gene expression fingerprint of C. elegans embryonic motor neurons. BMC Genomics (2005) 1.72
Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases. Hum Genet (2008) 1.72
Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics (2011) 1.68
A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction. Genet Epidemiol (2009) 1.61
Gut microbial colonisation in premature neonates predicts neonatal sepsis. Arch Dis Child Fetal Neonatal Ed (2012) 1.59
Accelerating epistasis analysis in human genetics with consumer graphics hardware. BMC Res Notes (2009) 1.58
Combinatorial pharmacogenetics. Nat Rev Drug Discov (2005) 1.58
Ecogeographic genetic epidemiology. Genet Epidemiol (2009) 1.57
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem (2006) 1.51
Evolving hard problems: Generating human genetics datasets with a complex etiology. BioData Min (2011) 1.47
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genet Epidemiol (2011) 1.47
Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. Proc Genet Evol Comput Conf (2002) 1.46
Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis (2006) 1.46
A system-level pathway-phenotype association analysis using synthetic feature random forest. Genet Epidemiol (2014) 1.46
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet (2009) 1.43
Risk estimation using probability machines. BioData Min (2014) 1.40
GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures. BioData Min (2012) 1.40
The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2005) 1.39
Problems with genome-wide association studies. Science (2007) 1.39
Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect (2008) 1.39
Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage. Pharmacogenet Genomics (2005) 1.38
A training-testing approach to the molecular classification of resected non-small cell lung cancer. Clin Cancer Res (2003) 1.36
Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. Genome Res (2012) 1.35
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Hum Genet (2007) 1.35
Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.33
Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics. Appl Soft Comput (2007) 1.33
Enabling personal genomics with an explicit test of epistasis. Pac Symp Biocomput (2010) 1.33
Cytokine expression patterns associated with systemic adverse events following smallpox immunization. J Infect Dis (2006) 1.29
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood (2012) 1.26
DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. Hum Hered (2007) 1.25
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav (2014) 1.23
A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits. PLoS One (2013) 1.20
Role for protein-protein interaction databases in human genetics. Expert Rev Proteomics (2009) 1.20
An information-gain approach to detecting three-way epistatic interactions in genetic association studies. J Am Med Inform Assoc (2013) 1.19
Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res (2008) 1.17
Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization. Circulation (2006) 1.17
Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies. Wiley Interdiscip Rev Syst Biol Med (2010) 1.15
A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet (2010) 1.14
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet (2013) 1.14
Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells. Arthritis Res Ther (2004) 1.14
Integrated analysis of genetic, genomic and proteomic data. Expert Rev Proteomics (2004) 1.12
Reporting of model validation procedures in human studies of genetic interactions. Nutrition (2004) 1.12
Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients. Arthritis Rheum (2008) 1.09
A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Ann Hum Genet (2010) 1.07
The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels. Thromb Haemost (2006) 1.06
Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J Pediatr (2003) 1.05
Big data bioinformatics. J Cell Physiol (2014) 1.04
Exploratory visual analysis of pharmacogenomic results. Pac Symp Biocomput (2005) 1.04
Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk. Prostate (2010) 1.02
COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults. J Int Neuropsychol Soc (2010) 1.01
Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. Brain Inj (2008) 1.01
A novel structure-aware sparse learning algorithm for brain imaging genetics. Med Image Comput Comput Assist Interv (2014) 1.01
The disconnect between classical biostatistics and the biological data mining community. BioData Min (2013) 1.00
Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: a learning classifier system approach. J Am Med Inform Assoc (2013) 1.00
The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings? Bioessays (2004) 0.98
Microarray analysis of cytoplasmic versus whole cell RNA reveals a considerable number of missed and false positive mRNAs. RNA (2009) 0.98
Predicting the difficulty of pure, strict, epistatic models: metrics for simulated model selection. BioData Min (2012) 0.98
A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis. Hum Hered (2010) 0.97
Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels. Genomics (2007) 0.97
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer. Pharmacogenet Genomics (2007) 0.96
Profiles of gene expression in human autoimmune disease. Cell Biochem Biophys (2004) 0.94
Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes. Am J Med Genet B Neuropsychiatr Genet (2010) 0.94
Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. BMC Med Genomics (2012) 0.94