Published in PLoS Genet on September 25, 2009
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol (2013) 1.19
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Mannose receptor 2 attenuates renal fibrosis. J Am Soc Nephrol (2011) 1.04
A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response. PLoS Genet (2012) 0.92
A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Dis Model Mech (2013) 0.90
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PLAG1 and NCAPG-LCORL in livestock. Anim Sci J (2015) 0.80
Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue Cattle. BMC Genomics (2014) 0.80
The mammalian cervical vertebrae blueprint depends on the T (brachyury) gene. Genetics (2015) 0.78
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Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL (CW-3) and Skeletal Dysplasia in Japanese Black Cattle. PLoS Genet (2015) 0.76
Loss of maternal ANNEXIN A10 via a 34-kb deleted-type copy number variation is associated with embryonic mortality in Japanese Black cattle. BMC Genomics (2016) 0.75
Genetic disorders in beef cattle: a review. Genes Genomics (2017) 0.75
Endo180 at the cutting edge of bone cancer treatment and beyond. J Pathol (2016) 0.75
A reverse genetic approach identifies an ancestral frameshift mutation in RP1 causing recessive progressive retinal degeneration in European cattle breeds. Genet Sel Evol (2016) 0.75
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol (2007) 16.15
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A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat Genet (1997) 7.15
Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet (2007) 5.99
A single IGF1 allele is a major determinant of small size in dogs. Science (2007) 4.68
Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science (1991) 3.85
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Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat Genet (2008) 2.68
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet (2008) 2.13
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens. PLoS Genet (2009) 2.10
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol (2003) 1.60
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Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol (2005) 1.42
Mannose receptor regulates myoblast motility and muscle growth. J Cell Biol (2006) 1.35
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep (2003) 1.31
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The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling. Biol Chem (2004) 1.24
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol (2007) 1.22
Periodic paralysis in quarter horses: a sodium channel mutation disseminated by selective breeding. Nat Genet (1992) 1.20
A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep. Anim Genet (2006) 1.12
Mannose receptor regulation of macrophage cell migration. J Leukoc Biol (2007) 0.96
Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 3. J Anim Sci (2006) 0.92
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet (2006) 8.37
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res (2002) 5.45
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature (2003) 5.41
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res (2005) 4.79
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Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. N Engl J Med (2014) 4.00
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus. Curr Biol (2005) 3.65
A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood (2009) 3.63
Domestic-animal genomics: deciphering the genetics of complex traits. Nat Rev Genet (2004) 3.42
Whole genome linkage disequilibrium maps in cattle. BMC Genet (2007) 3.28
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J Cell Biol (2006) 3.24
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet (2010) 3.22
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The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes. Trends Genet (2003) 2.99
Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature. Nat Genet (2011) 2.81
Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc Natl Acad Sci U S A (2004) 2.72
Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat Genet (2008) 2.68
A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping. Genetics (2009) 2.37
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat Genet (2010) 2.12
Exome sequencing reveals a novel Moroccan founder mutation in SLC19A3 as a new cause of early-childhood fatal Leigh syndrome. Brain (2013) 2.03
Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett (2005) 1.96
A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nat Cell Biol (2002) 1.94
KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. Brain (2003) 1.92
Schmallenberg virus in calf born at term with porencephaly, Belgium. Emerg Infect Dis (2012) 1.77
Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue. BMC Cell Biol (2008) 1.75
A common reference population from four European Holstein populations increases reliability of genomic predictions. Genet Sel Evol (2011) 1.74
Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Res (2009) 1.60
The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events. J Cell Sci (2004) 1.55
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing. Genome Biol (2011) 1.53
An assessment of population structure in eight breeds of cattle using a whole genome SNP panel. BMC Genet (2008) 1.51
A high density linkage map of the bovine genome. BMC Genet (2009) 1.49
Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene. Genesis (2003) 1.48
Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell (2003) 1.44
Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype. Genetics (2003) 1.36
Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem Cells (2012) 1.35
A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One (2010) 1.34
A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer Res (2007) 1.33
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep (2003) 1.31
The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein production in Finnish Ayrshire dairy cattle. Genetics (2006) 1.30
Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. Eur J Immunol (2006) 1.30
Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. Clin Cancer Res (2007) 1.28
Improved risk prediction for Crohn's disease with a multi-locus approach. Hum Mol Genet (2011) 1.28
Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod Pathol (2008) 1.26
A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina. PLoS One (2012) 1.25
A global view of porcine transcriptome in three tissues from a full-sib pair with extreme phenotypes in growth and fat deposition by paired-end RNA sequencing. BMC Genomics (2011) 1.24
Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype. Curr Biol (2004) 1.24
Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene Expr Patterns (2006) 1.21
Genetical metabolomics of flavonoid biosynthesis in Populus: a case study. Plant J (2006) 1.18
RET in breast cancer: functional and therapeutic implications. Trends Mol Med (2011) 1.18
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle. PLoS Genet (2012) 1.16
Serial translocation by means of circular intermediates underlies colour sidedness in cattle. Nature (2012) 1.16
CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett (2007) 1.16
LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. Vet J (2011) 1.15
Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene. Genetics (2003) 1.13
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem (2007) 1.13
The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. J Biol Chem (2002) 1.12
Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol (2006) 1.12
MicroRNA-200 family modulation in distinct breast cancer phenotypes. PLoS One (2012) 1.10
GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol (2003) 1.10
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem (2011) 1.09
Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines. J Immunol (2004) 1.09