Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor.

PubWeight™: 1.44‹?› | Rank: Top 5%

🔗 View Article (PMC 196552)

Published in Mol Biol Cell on July 25, 2003

Authors

Dirk Wienke1, John R MacFadyen, Clare M Isacke

Author Affiliations

1: The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom.

Articles citing this

Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. J Cell Sci (2008) 1.49

Fibronectin matrix turnover occurs through a caveolin-1-dependent process. Mol Biol Cell (2004) 1.40

A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One (2010) 1.34

A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep (2003) 1.31

Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol (2007) 1.22

M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol (2013) 1.19

Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol (2006) 1.12

Collagen I matrix turnover is regulated by fibronectin polymerization. Am J Physiol Cell Physiol (2010) 1.11

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol (2003) 1.10

Serine proteases, inhibitors and receptors in renal fibrosis. Thromb Haemost (2009) 1.10

The non-phagocytic route of collagen uptake: a distinct degradation pathway. J Biol Chem (2011) 1.09

Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle. PLoS Genet (2009) 1.07

Mannose receptor 2 attenuates renal fibrosis. J Am Soc Nephrol (2011) 1.04

Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. J Cell Sci (2009) 1.00

Collagen binding by the mannose receptor mediated through the fibronectin type II domain. Biochem J (2006) 0.98

Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals. Mol Ther (2011) 0.92

A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. J Biol Chem (2011) 0.90

Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep (2003) 0.90

Pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition. PLoS One (2012) 0.88

Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180. Biochem J (2005) 0.88

Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation. Immunology (2006) 0.88

Role of urokinase plasminogen activator receptor-associated protein in mouse lung. Am J Respir Cell Mol Biol (2011) 0.87

MRC2 expression correlates with TGFβ1 and survival in hepatocellular carcinoma. Int J Mol Sci (2014) 0.86

Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. Br J Cancer (2012) 0.86

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clin Exp Metastasis (2015) 0.83

Complex determinants in specific members of the mannose receptor family govern collagen endocytosis. J Biol Chem (2014) 0.83

Collagen inhibitory peptide R1R2 mediates vascular remodeling by decreasing inflammation and smooth muscle cell activation. PLoS One (2015) 0.81

Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation. Development (2014) 0.80

Migration of intervertebral disc cells into dense collagen scaffolds intended for functional replacement. J Mater Sci Mater Med (2012) 0.79

Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species. BMC Cell Biol (2009) 0.79

uPARAP function in cutaneous wound repair. PLoS One (2014) 0.78

The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). Int J Oncol (2015) 0.78

Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. Am J Physiol Cell Physiol (2014) 0.77

Lysosomal trafficking of TGFBIp via caveolae-mediated endocytosis. PLoS One (2015) 0.77

Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure (2015) 0.76

Endo180 at the cutting edge of bone cancer treatment and beyond. J Pathol (2016) 0.75

Articles cited by this

Genes expressed in human tumor endothelium. Science (2000) 10.75

Endocytosis and molecular sorting. Annu Rev Cell Dev Biol (1996) 8.83

Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem (1995) 5.52

The endocytic pathway: a mosaic of domains. Nat Rev Mol Cell Biol (2001) 4.57

The mannose receptor family. Biochim Biophys Acta (2002) 3.02

Codistribution of collagen types IV and AB2 in basement membranes and mesangium of the kidney. an immunoferritin study of ultrathin frozen sections. J Cell Biol (1980) 2.30

Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites. Biochem Biophys Res Commun (1992) 2.04

Collagen: molecular diversity in the body's protein scaffold. Science (1980) 2.04

Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol (2001) 2.01

Matrix metalloproteinases in tumor invasion. Cell Mol Life Sci (2000) 1.66

Matrix metalloproteinases and collagen catabolism. Biopolymers (2002) 1.64

Discoidin domain receptor 1 is activated independently of beta(1) integrin. J Biol Chem (2000) 1.64

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol (2003) 1.60

Scavenger functions of the liver endothelial cell. Biochem J (1990) 1.59

Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain Res Brain Res Rev (2001) 1.59

Urokinase receptor: a molecular organizer in cellular communication. Curr Opin Cell Biol (2000) 1.52

Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. J Cell Sci (2000) 1.50

A urokinase receptor-associated protein with specific collagen binding properties. J Biol Chem (2000) 1.44

Extracellular matrix binding properties of recombinant fibronectin type II-like modules of human 72-kDa gelatinase/type IV collagenase. High affinity binding to native type I collagen but not native type IV collagen. J Biol Chem (1995) 1.36

Role of integrins in regulation of collagen phagocytosis by human fibroblasts. J Cell Physiol (1996) 1.32

A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep (2003) 1.31

p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol Cell Biol (1990) 1.28

Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase. J Biol Chem (1992) 1.28

Characterization of a novel member of the macrophage mannose receptor type C lectin family. J Biol Chem (1996) 1.24

The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis. Lab Invest (2001) 1.19

New members of the collagen superfamily. Curr Opin Cell Biol (1993) 1.16

Ultrastructural localization of type V collagen in rat kidney. J Cell Biol (1982) 1.14

The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding. EMBO J (2001) 1.13

The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. J Biol Chem (2002) 1.12

Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells. Int J Cancer (2002) 1.12

A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblasts. J Biol Chem (2000) 1.11

Characterization of sugar binding by the mannose receptor family member, Endo180. J Biol Chem (2002) 1.08

Further localization of the gelatin-binding determinants within fibronectin. Active fragments devoid of type II homologous repeat modules. J Biol Chem (1989) 1.01

Studies in vivo and in vitro on the uptake and degradation of soluble collagen alpha 1(I) chains in rat liver endothelial and Kupffer cells. Biochem J (1985) 1.00

The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A). Biochem J (1994) 1.00

Solution structure of a type 2 module from fibronectin: implications for the structure and function of the gelatin-binding domain. Structure (1997) 0.98

The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer. Anticancer Drugs (2001) 0.98

Distribution of type I collagen in human kidney diseases in comparison with type III collagen. J Pathol (1990) 0.97

All six modules of the gelatin-binding domain of fibronectin are required for full affinity. J Biol Chem (2003) 0.96

The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64. Coll Relat Res (1985) 0.93

A role for collagen phagocytosis by fibroblasts in scar remodeling: an ultrastructural stereologic study. J Invest Dermatol (1983) 0.93

Mapping the collagen-binding site of human fibronectin by expression in Escherichia coli. EMBO J (1986) 0.92

A stereologic analysis of collagen phagocytosis by fibroblasts in three soft connective tissues with differing rates of collagen turnover. Anat Rec (1981) 0.90

Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep (2003) 0.90

Pathology of collagen degradation. A review. Am J Pathol (1978) 0.89

Collagen-binding recombinant fibronectin fragments containing type II domains. FEBS Lett (1994) 0.80

Intracellular fate of endocytosed collagen in rat liver endothelial cells. Exp Cell Res (1996) 0.78

Articles by these authors

CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res (2005) 4.79

A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood (2009) 3.63

Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J Cell Biol (2006) 3.24

The mannose receptor family. Biochim Biophys Acta (2002) 3.02

Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett (2005) 1.96

A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nat Cell Biol (2002) 1.94

Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue. BMC Cell Biol (2008) 1.75

The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events. J Cell Sci (2004) 1.55

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing. Genome Biol (2011) 1.53

Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem Cells (2012) 1.35

A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One (2010) 1.34

A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer Res (2007) 1.33

A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep (2003) 1.31

Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. Eur J Immunol (2006) 1.30

Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. Clin Cancer Res (2007) 1.28

Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma. Mod Pathol (2008) 1.26

Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation. J Biol Chem (2007) 1.24

Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene Expr Patterns (2006) 1.21

RET in breast cancer: functional and therapeutic implications. Trends Mol Med (2011) 1.18

CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett (2007) 1.16

Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem (2007) 1.13

The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. J Biol Chem (2002) 1.12

Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol (2006) 1.12

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol (2003) 1.10

MicroRNA-200 family modulation in distinct breast cancer phenotypes. PLoS One (2012) 1.10

Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem (2011) 1.09

Characterization of sugar binding by the mannose receptor family member, Endo180. J Biol Chem (2002) 1.08

Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J Biol Chem (2006) 1.08

The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Res (2007) 1.07

An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor. Cancer Discov (2014) 1.07

Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle. PLoS Genet (2009) 1.07

Pericytes promote selective vessel regression to regulate vascular patterning. Blood (2012) 1.07

Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. J Cell Sci (2005) 1.05

CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification. Breast Cancer Res Treat (2009) 1.05

CD248+ stromal cells are associated with progressive chronic kidney disease. Kidney Int (2011) 1.04

Mannose receptor 2 attenuates renal fibrosis. J Am Soc Nephrol (2011) 1.04

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor. Breast Cancer Res Treat (2012) 1.03

Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. J Cell Sci (2009) 1.00

Mannose receptor regulation of macrophage cell migration. J Leukoc Biol (2007) 0.96

The intraductal approach to breast cancer biomarker discovery. J Clin Oncol (2006) 0.95

The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur J Immunol (2010) 0.95

GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res (2013) 0.94

Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep (2003) 0.90

Endo180 binds to the C-terminal region of type I collagen. J Biol Chem (2005) 0.88

A new spreadsheet method for the analysis of bivariate flow cytometric data. BMC Cell Biol (2004) 0.88

Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation. J Pathol (2009) 0.87

Multiple immunofluorescence labeling of formalin-fixed paraffin-embedded tissue. Methods Mol Biol (2011) 0.85

PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. Exp Cell Res (2003) 0.85

DNA promoter hypermethylation profiles in breast duct fluid. Breast Cancer Res Treat (2013) 0.84

The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation. Immunology (2011) 0.83

Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. Biochem J (2002) 0.81

Report on antibodies submitted to the stromal cell section of HLDA8. Cell Immunol (2005) 0.80

The 'alternative' EMT switch. Breast Cancer Res (2011) 0.80

Proteomic analysis of nipple aspirate fluid throughout the menstrual cycle in healthy pre-menopausal women. Breast Cancer Res Treat (2006) 0.78

Mammary ductoscopy in the current management of breast disease. Surg Endosc (2010) 0.78

Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Breast Cancer Res (2015) 0.78

The feasibility of nipple aspiration and duct lavage to evaluate the breast duct epithelium of women with increased breast cancer risk. Eur J Cancer (2012) 0.78

The anatomy of fluid-yielding ducts in breast cancer. Breast Cancer Res Treat (2011) 0.77

Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in breast cancer. Breast Cancer Res (2014) 0.77

CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. FEBS Open Bio (2012) 0.76

Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients. Radiat Oncol (2011) 0.75