Interactions between lipids and voltage sensor paddles detected with tarantula toxins.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMC 2782670)

Published in Nat Struct Mol Biol on September 27, 2009

Authors

Mirela Milescu1, Frank Bosmans, Seungkyu Lee, AbdulRasheed A Alabi, Jae Il Kim, Kenton J Swartz

Author Affiliations

1: Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. Mirela.Milescu@nih.gov

Articles citing this

Structure and hydration of membranes embedded with voltage-sensing domains. Nature (2009) 2.15

A shaker K+ channel with a miniature engineered voltage sensor. Cell (2010) 2.00

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58

Contributions of counter-charge in a potassium channel voltage-sensor domain. Nat Chem Biol (2011) 1.32

An electrostatic potassium channel opener targeting the final voltage sensor transition. J Gen Physiol (2011) 1.25

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature (2016) 1.19

Targeting voltage sensors in sodium channels with spider toxins. Trends Pharmacol Sci (2010) 1.14

Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis. J Biol Chem (2010) 1.13

PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proc Natl Acad Sci U S A (2012) 1.13

Electrostatic tuning of cellular excitability. Biophys J (2010) 1.11

From foe to friend: using animal toxins to investigate ion channel function. J Mol Biol (2014) 1.04

The hitchhiker's guide to the voltage-gated sodium channel galaxy. J Gen Physiol (2016) 1.03

Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation. PLoS Comput Biol (2013) 1.01

Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications. Physiol Rev (2013) 0.99

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors. J Gen Physiol (2011) 0.98

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. J Gen Physiol (2014) 0.97

PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating. Front Physiol (2014) 0.97

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proc Natl Acad Sci U S A (2014) 0.94

Voltage-gated channel mechanosensitivity: fact or friction? Front Physiol (2011) 0.93

Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophys J (2010) 0.91

A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. J Gen Physiol (2015) 0.91

Palmitoylation influences the function and pharmacology of sodium channels. Proc Natl Acad Sci U S A (2011) 0.91

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin. Elife (2016) 0.90

Exploring structure-function relationships between TRP and Kv channels. Sci Rep (2013) 0.90

KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene (2015) 0.89

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nat Commun (2014) 0.88

Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists? Front Pharmacol (2012) 0.87

Opening the shaker K+ channel with hanatoxin. J Gen Physiol (2013) 0.87

Connection between oligomeric state and gating characteristics of mechanosensitive ion channels. PLoS Comput Biol (2013) 0.86

Position and motions of the S4 helix during opening of the Shaker potassium channel. J Gen Physiol (2010) 0.86

Animal toxins can alter the function of Nav1.8 and Nav1.9. Toxins (Basel) (2012) 0.86

Interactions between a voltage sensor and a toxin via multiscale simulations. Biophys J (2010) 0.86

Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels. Front Pharmacol (2012) 0.86

Structural interactions between lipids, water and S1-S4 voltage-sensing domains. J Mol Biol (2012) 0.86

Directional interactions and cooperativity between mechanosensitive membrane proteins. Europhys Lett (2013) 0.86

Structural interactions of a voltage sensor toxin with lipid membranes. Proc Natl Acad Sci U S A (2014) 0.84

Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP. Biochemistry (2012) 0.84

Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels . Biochemistry (2010) 0.84

Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife (2015) 0.83

Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase. J Gen Physiol (2013) 0.82

Interaction of diverse voltage sensor homologs with lipid bilayers revealed by self-assembly simulations. Biophys J (2011) 0.81

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J Biol Chem (2016) 0.80

The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel. PLoS Comput Biol (2016) 0.80

Voltage gated ion channel function: gating, conduction, and the role of water and protons. Int J Mol Sci (2012) 0.79

Structural basis for the inhibition of voltage-dependent K+ channel by gating modifier toxin. Sci Rep (2015) 0.79

Autonomous transmembrane segment S4 of the voltage sensor domain partitions into the lipid membrane. Biochim Biophys Acta (2012) 0.78

Toxin diversity revealed by a transcriptomic study of Ornithoctonus huwena. PLoS One (2014) 0.78

Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca(2+) channels. Biochemistry (2012) 0.78

Retracted Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases. J Lipid Res (2016) 0.77

Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current. J Gen Physiol (2015) 0.77

Binding of hanatoxin to the voltage sensor of Kv2.1. Toxins (Basel) (2012) 0.76

Mechanosensitive gating of Kv channels. PLoS One (2015) 0.76

Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP? J Biol Chem (2014) 0.76

An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV. PLoS One (2015) 0.76

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases. J Lipid Res (2017) 0.75

Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels. Sci Rep (2016) 0.75

Sphingomyelin, ORAI1 channels, and cellular Ca2+ signaling. J Gen Physiol (2015) 0.75

Articles cited by this

The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (2005) 17.70

X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35

Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85

Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron (1989) 5.13

Phospholipids and the origin of cationic gating charges in voltage sensors. Nature (2006) 3.99

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature (1989) 3.99

Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science (1995) 3.82

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles. J Mol Biol (1995) 3.76

Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science (2004) 3.59

Lipid-protein interactions in biological membranes: a structural perspective. Biochim Biophys Acta (2003) 3.44

Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron (1988) 3.40

S4-based voltage sensors have three major conformations. Proc Natl Acad Sci U S A (2008) 3.21

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell (2005) 2.97

A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature (2004) 2.74

Lipids in membrane protein structures. Biochim Biophys Acta (2004) 2.67

Sensing voltage across lipid membranes. Nature (2008) 2.66

alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 2.46

Portability of paddle motif function and pharmacology in voltage sensors. Nature (2007) 2.43

Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature (2003) 2.42

Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron (1997) 2.35

Deconstructing voltage sensor function and pharmacology in sodium channels. Nature (2008) 2.32

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel. Neuron (2006) 2.25

Voltage-sensor activation with a tarantula toxin as cargo. Nature (2005) 2.16

Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels. Nature (2008) 2.09

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07

Differential targeting of Shaker-like potassium channels to lipid rafts. J Biol Chem (2000) 2.02

The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron (2003) 1.96

Enzymatic activation of voltage-gated potassium channels. Nature (2006) 1.77

Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 1.77

Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (2008) 1.64

Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel. Biochemistry (2005) 1.61

Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol (2009) 1.60

Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol (2007) 1.58

Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry (2002) 1.48

Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. J Gen Physiol (2001) 1.47

Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes (2006) 1.35

Movement and crevices around a sodium channel S3 segment. J Gen Physiol (2002) 1.18

Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins. J Biol Chem (2002) 1.17

Inferred motions of the S3a helix during voltage-dependent K+ channel gating. J Mol Biol (2008) 1.11

Sphingolipid-binding proteins. Biochim Biophys Acta (2006) 1.01

Constraints on voltage sensor movement in the shaker K+ channel. J Gen Physiol (2006) 0.96

Articles by these authors

Portability of paddle motif function and pharmacology in voltage sensors. Nature (2007) 2.43

Deconstructing voltage sensor function and pharmacology in sodium channels. Nature (2008) 2.32

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel. Neuron (2006) 2.25

Scanning the intracellular S6 activation gate in the shaker K+ channel. J Gen Physiol (2002) 2.23

Voltage-sensor activation with a tarantula toxin as cargo. Nature (2005) 2.16

Structure and hydration of membranes embedded with voltage-sensing domains. Nature (2009) 2.15

Gating the pore of P2X receptor channels. Nat Neurosci (2008) 1.70

Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels. Neuron (2007) 1.62

Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel. Biochemistry (2005) 1.61

Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol (2007) 1.58

Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels. Neuron (2003) 1.53

Mechanosensitive nonselective cation channel facilitation by endothelin-1 is regulated by protein kinase C in arterial myocytes. Cardiovasc Res (2007) 1.48

Constitutive activation of the Shaker Kv channel. J Gen Physiol (2003) 1.47

Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal. J Gen Physiol (2004) 1.44

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem (2008) 1.37

A novel flavin-containing monooxygenase from Methylophaga sp strain SK1 and its indigo synthesis in Escherichia coli. Biochem Biophys Res Commun (2003) 1.35

Pore-opening mechanism in trimeric P2X receptor channels. Nat Commun (2010) 1.34

Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels. J Gen Physiol (2005) 1.30

Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating. Biochemistry (2004) 1.25

Ion access pathway to the transmembrane pore in P2X receptor channels. J Gen Physiol (2011) 1.24

Clinical characteristics of primary epiploic appendagitis. J Korean Soc Coloproctol (2011) 1.21

Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs. Mol Endocrinol (2004) 1.18

Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J Gen Physiol (2004) 1.14

Targeting voltage sensors in sodium channels with spider toxins. Trends Pharmacol Sci (2010) 1.14

Animal peptides targeting voltage-activated sodium channels. Curr Pharm Des (2008) 1.11

Coumarin-derived Cu(2+)-selective fluorescence sensor: synthesis, mechanisms, and applications in living cells. J Am Chem Soc (2009) 1.10

The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn. J Biol Chem (2006) 1.06

CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils. J Leukoc Biol (2007) 1.06

Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A. Biochem J (2004) 1.05

Defining the conductance of the closed state in a voltage-gated K+ channel. Neuron (2003) 1.01

Clinical characteristics of benign paroxysmal positional vertigo in Korea: a multicenter study. J Korean Med Sci (2006) 1.00

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett (2003) 1.00

Crystallographic insights into sodium-channel modulation by the β4 subunit. Proc Natl Acad Sci U S A (2013) 1.00

Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. J Virol (2008) 0.99

Adaptive evolution of scorpion sodium channel toxins. J Mol Evol (2004) 0.99

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors. J Gen Physiol (2011) 0.98

Teaching neuroimage: sensory level in parietal lobe lesion. Neurology (2007) 0.97

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels. J Biol Chem (2006) 0.96

High methane storage capacity in aluminum metal-organic frameworks. J Am Chem Soc (2014) 0.96

OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett (2005) 0.96

The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae. FEBS Lett (2006) 0.95

Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels. Proc Natl Acad Sci U S A (2013) 0.93

Salt resistance and synergistic effect with vancomycin of alpha-helical antimicrobial peptide P18. Biochem Biophys Res Commun (2002) 0.93

Substitution of the leucine zipper sequence in melittin with peptoid residues affects self-association, cell selectivity, and mode of action. Biochim Biophys Acta (2007) 0.92

Carbon-nanotube/silver networks in nitrile butadiene rubber for highly conductive flexible adhesives. Adv Mater (2012) 0.92

Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1. Biochem Biophys Res Commun (2006) 0.92

Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophys J (2010) 0.91

Cell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues. Biochemistry (2005) 0.91

Opening the gate in potassium channels. Nat Struct Mol Biol (2004) 0.91

Palmitoylation influences the function and pharmacology of sodium channels. Proc Natl Acad Sci U S A (2011) 0.91

In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer. Biomaterials (2011) 0.91

Exploring structure-function relationships between TRP and Kv channels. Sci Rep (2013) 0.90

A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity. Life Sci (2008) 0.89

Selective cytotoxicity following Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure. FEBS Lett (2003) 0.89

Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1. FASEB J (2005) 0.89

Effects of L- or D-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic alpha-helical model peptide on structure and cell selectivity. Biochem Biophys Res Commun (2004) 0.88

Engineering of protease variants exhibiting altered substrate specificity. Biochem Biophys Res Commun (2008) 0.88

Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited. J Biol Chem (2003) 0.88

Contribution of a central proline in model amphipathic alpha-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action. FEBS J (2006) 0.88

Intramolecular Huisgen-type cyclization of platinum-bound pyrylium ions with alkenes and subsequent insertion into a benzylic C-H bond. Angew Chem Int Ed Engl (2008) 0.87

First report of human acute acalculous cholecystitis caused by the fish pathogen Lactococcus garvieae. J Clin Microbiol (2012) 0.87

Solution structure of termite-derived antimicrobial peptide, spinigerin, as determined in SDS micelle by NMR spectroscopy. Biochem Biophys Res Commun (2003) 0.87

Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide. Biochem Biophys Res Commun (2002) 0.87

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. Br J Pharmacol (2015) 0.87

Opening the shaker K+ channel with hanatoxin. J Gen Physiol (2013) 0.87

Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1. J Mol Biol (2005) 0.87

Comparison of clinical outcomes and hospital cost between open appendectomy and laparoscopic appendectomy. J Korean Surg Soc (2011) 0.86

Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2. Biochim Biophys Acta (2009) 0.86

Animal toxins can alter the function of Nav1.8 and Nav1.9. Toxins (Basel) (2012) 0.86

Animal toxins influence voltage-gated sodium channel function. Handb Exp Pharmacol (2014) 0.86

Position and motions of the S4 helix during opening of the Shaker potassium channel. J Gen Physiol (2010) 0.86

Structural interactions between lipids, water and S1-S4 voltage-sensing domains. J Mol Biol (2012) 0.86

Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorg Med Chem (2005) 0.85

Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels. Biochem J (2003) 0.85

High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels. PLoS One (2012) 0.85

An inhibitor of TRPV1 channels isolated from funnel Web spider venom. Biochemistry (2005) 0.85

Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology (2014) 0.84

Membrane perturbation by the antimicrobial peptide PMAP-23: a fluorescence and molecular dynamics study. Biochim Biophys Acta (2009) 0.84

Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+. Proc Natl Acad Sci U S A (2013) 0.84

Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels . Biochemistry (2010) 0.84

Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun (2005) 0.83

Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity. Biotechnol Lett (2008) 0.83

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop. FEBS J (2015) 0.83

Elucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels. Mol Pharmacol (2011) 0.83

The role of the central L- or D-Pro residue on structure and mode of action of a cell-selective alpha-helical IsCT-derived antimicrobial peptide. Biochem Biophys Res Commun (2005) 0.82

New "Birtoxin analogs" from Androctonus australis venom. Biochem Biophys Res Commun (2005) 0.82

Hybrid exposure for depth imaging of a time-of-flight depth sensor. Opt Express (2014) 0.82

Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. Biochemistry (2006) 0.82

Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin. Peptides (2008) 0.81