Published in Curr Pharm Des on January 01, 2008
Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife (2013) 1.31
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A (2011) 1.30
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A (2013) 1.29
Neurotoxins and their binding areas on voltage-gated sodium channels. Front Pharmacol (2011) 1.15
μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels. Biochemistry (2010) 0.99
Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB. J Pharmacol Exp Ther (2011) 0.94
Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective. BMC Genomics (2010) 0.94
New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing. J Biol Chem (2012) 0.91
Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels. Mol Cell Proteomics (2011) 0.89
Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis. J Biol Chem (2010) 0.85
Developing a comparative docking protocol for the prediction of peptide selectivity profiles: investigation of potassium channel toxins. Toxins (Basel) (2012) 0.81
A new look at sodium channel β subunits. Open Biol (2015) 0.80
Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics. Future Med Chem (2014) 0.79
Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel) (2014) 0.78
Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana. J Biol Chem (2013) 0.78
Synthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain. Toxins (Basel) (2014) 0.77
Mutational analysis of the analgesic peptide DrTx(1-42) revealing a functional role of the amino-terminal turn. PLoS One (2012) 0.77
Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J Biol Chem (2016) 0.77
Seeing is believing: Dynamic evolution of gene families. Proc Natl Acad Sci U S A (2015) 0.76
A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii. Toxins (Basel) (2016) 0.76
TTX, cations and spider venom modify avian muscle tone in vitro. J Venom Res (2011) 0.75
Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation. Br J Pharmacol (2015) 0.75
Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall. Eur Urol (2013) 2.15
Interactions between lipids and voltage sensor paddles detected with tarantula toxins. Nat Struct Mol Biol (2009) 1.56
Evolutionary origin of inhibitor cystine knot peptides. FASEB J (2003) 1.31
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol (2005) 1.31
An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon (2002) 1.29
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22
Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein. J Biol Chem (2010) 1.18
kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity. J Biol Chem (2002) 1.17
Neurotoxins and their binding areas on voltage-gated sodium channels. Front Pharmacol (2011) 1.15
The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. Toxicon (2006) 1.12
Voltage-gated sodium channel modulation by scorpion alpha-toxins. Toxicon (2006) 1.12
Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem (2002) 1.09
Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol Pharmacol (2006) 1.08
Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett (2003) 1.00
Crystallographic insights into sodium-channel modulation by the β4 subunit. Proc Natl Acad Sci U S A (2013) 1.00
Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett (2006) 1.00
Adaptive evolution of scorpion sodium channel toxins. J Mol Evol (2004) 0.99
A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem Pharmacol (2011) 0.98
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon (2008) 0.97
OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae. Toxicon (2008) 0.96
Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels. J Biol Chem (2006) 0.96
Evolutionary epitopes of Hsp90 and p23: implications for their interaction. FASEB J (2004) 0.96
An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis. Biochem J (2005) 0.96
OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett (2005) 0.96
The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae. FEBS Lett (2006) 0.95
Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. Toxicon (2006) 0.94
Turret and pore block of K+ channels: what is the difference? Trends Pharmacol Sci (2003) 0.93
BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. J Biol Chem (2004) 0.92
Experimental conversion of a defensin into a neurotoxin: implications for origin of toxic function. Mol Biol Evol (2014) 0.92
Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes. J Biol Chem (2009) 0.91
Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels. Mol Cell Proteomics (2011) 0.89
An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera. Peptides (2008) 0.89
Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom. Eur J Biochem (2002) 0.89
A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J (2012) 0.89
Evolutionary trace analysis of scorpion toxins specific for K-channels. Proteins (2004) 0.89
Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1. FASEB J (2005) 0.89
Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J (2011) 0.88
Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited. J Biol Chem (2003) 0.88
Molecular diversity and functional evolution of scorpion potassium channel toxins. Mol Cell Proteomics (2010) 0.88
Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation. J Biol Chem (2004) 0.88
Crotamine pharmacology revisited: novel insights based on the inhibition of KV channels. Mol Pharmacol (2012) 0.87
Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. Br J Pharmacol (2015) 0.87
TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochem Biophys Res Commun (2007) 0.87
Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1. J Mol Biol (2005) 0.87
The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett (2002) 0.86
Animal toxins influence voltage-gated sodium channel function. Handb Exp Pharmacol (2014) 0.86
Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2. Biochim Biophys Acta (2009) 0.86
Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels. Biochem Biophys Res Commun (2002) 0.86
Animal toxins can alter the function of Nav1.8 and Nav1.9. Toxins (Basel) (2012) 0.86
Molecular diversity of the telson and venom components from Pandinus cavimanus (Scorpionidae Latreille 1802): transcriptome, venomics and function. Proteomics (2012) 0.86
Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily. Biochem Pharmacol (2012) 0.86
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc Natl Acad Sci U S A (2009) 0.85
Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis. J Biol Chem (2010) 0.85
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. Br J Pharmacol (2012) 0.85
Design of bioactive peptides from naturally occurring μ-conotoxin structures. J Biol Chem (2012) 0.85
Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels. Biochem J (2003) 0.85
The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum. Peptides (2011) 0.85
Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function. Cell Mol Life Sci (2010) 0.84
A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J Biol Chem (2003) 0.84
Assignment of voltage-gated potassium channel blocking activity to kappa-KTx1.3, a non-toxic homologue of kappa-hefutoxin-1, from Heterometrus spinifer venom. Biochem Pharmacol (2004) 0.84
The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop. FEBS J (2015) 0.83
Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom. FEBS J (2012) 0.83
Molecular divergence of two orthologous scorpion toxins affecting potassium channels. Comp Biochem Physiol A Mol Integr Physiol (2011) 0.83
Novel conopeptides of the I-superfamily occur in several clades of cone snails. Toxicon (2004) 0.82
Biochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar Drugs (2013) 0.82
Novel potassium channel blocker venom peptides from Mesobuthus gibbosus (Scorpiones: Buthidae). Toxicon (2012) 0.82
Voltage-gated sodium channel isoform-specific effects of pompilidotoxins. FEBS J (2010) 0.82
BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochem J (2004) 0.82
New "Birtoxin analogs" from Androctonus australis venom. Biochem Biophys Res Commun (2005) 0.82
Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity. Toxicol Appl Pharmacol (2006) 0.82
MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity. Biochim Biophys Acta (2010) 0.82
Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proc Natl Acad Sci U S A (2013) 0.82
The poison Dart frog's batrachotoxin modulates Nav1.8. FEBS Lett (2004) 0.81
Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: a "joint venture" alkaloid from arthropods and amphibians. Toxicon (2007) 0.81
Structure-function elucidation of a new α-conotoxin, Lo1a, from Conus longurionis. J Biol Chem (2014) 0.81
A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes. Biochem Biophys Res Commun (2008) 0.81
Spider peptide toxins as leads for drug development. Expert Opin Drug Discov (2007) 0.81
A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily. FEBS Lett (2006) 0.81
The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel. Toxicon (2005) 0.81
Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms. Toxicon (2008) 0.81
Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels. Toxicon (2008) 0.81
A subfamily of acidic alpha-K(+) toxins. J Biol Chem (2003) 0.81
Drug- and mutagenesis-induced changes in the selectivity filter of a cardiac two-pore background K+ channel. Cardiovasc Res (2003) 0.81
A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels. Toxicon (2003) 0.81
Cardiac channelopathy causing sudden death as revealed by molecular autopsy. Int J Legal Med (2012) 0.80
Determination of species-specific components in the venom of Parabuthus scorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometry. Rapid Commun Mass Spectrom (2002) 0.80
Characterization of scorpion alpha-like toxin group using two new toxins from the scorpion Leiurus quinquestriatus hebraeus. Eur J Biochem (2002) 0.80