CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

PubWeight™: 10.44‹?› | Rank: Top 0.1%

🔗 View Article (PMC 1307559)

Published in J Clin Invest on December 08, 2005

Authors

Stuart P Weisberg1, Deborah Hunter, Reid Huber, Jacob Lemieux, Sarah Slaymaker, Kris Vaddi, Israel Charo, Rudolph L Leibel, Anthony W Ferrante

Author Affiliations

1: Department of Medicine, Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

Articles citing this

(truncated to the top 100)

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19

Inflammation and insulin resistance. J Clin Invest (2006) 18.76

Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 13.44

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59

Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52

Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92

Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71

Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28

Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15

Mechanisms for insulin resistance: common threads and missing links. Cell (2012) 6.85

Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest (2008) 6.60

Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83

The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10

Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68

Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 4.56

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56

NF-κB, inflammation, and metabolic disease. Cell Metab (2011) 4.00

The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93

Alternative macrophage activation and metabolism. Annu Rev Pathol (2011) 3.59

Inflammation and insulin resistance. FEBS Lett (2007) 3.34

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes (2009) 3.27

Inflamed fat: what starts the fire? J Clin Invest (2006) 3.11

Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol (2009) 3.09

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab (2006) 3.04

Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet (2008) 2.96

Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science (2013) 2.85

Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol (2008) 2.82

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73

Inflammatory mechanisms in the regulation of insulin resistance. Mol Med (2008) 2.71

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest (2008) 2.55

Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49

Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes (2009) 2.42

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36

CCR2 promotes hepatic fibrosis in mice. Hepatology (2009) 2.35

Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes (2010) 2.35

Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes (2009) 2.27

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med (2011) 2.25

Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab (2008) 2.24

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum (2009) 2.24

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res (2010) 2.16

Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem (2009) 2.11

Immunological complications of obesity. Nat Immunol (2012) 2.09

Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med (2012) 2.07

Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci (2014) 2.03

The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev (2012) 2.01

Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab (2009) 2.00

Increased macrophage migration into adipose tissue in obese mice. Diabetes (2011) 1.98

Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.97

Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology (2011) 1.94

Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) (2011) 1.90

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol (2012) 1.87

C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes (2010) 1.86

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab (2013) 1.85

Immunological goings-on in visceral adipose tissue. Cell Metab (2013) 1.84

Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res (2011) 1.83

Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials (2012) 1.81

Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep (2009) 1.76

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology (2008) 1.76

Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. J Biol Chem (2012) 1.75

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J (2011) 1.72

NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. Gut Liver (2012) 1.70

Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res (2013) 1.69

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68

IL-17 regulates adipogenesis, glucose homeostasis, and obesity. J Immunol (2010) 1.67

Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J Clin Endocrinol Metab (2011) 1.65

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest (2009) 1.63

Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 1.62

Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2008) 1.62

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta (2013) 1.60

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J (2010) 1.60

Adipose tissue recruitment of leukocytes. Curr Opin Lipidol (2010) 1.60

Insulin resistance and pancreatic beta cell failure. J Clin Invest (2006) 1.60

A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial. J Transl Med (2012) 1.59

Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes (2009) 1.59

Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol (2009) 1.59

Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm (2013) 1.59

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue. Int J Obes (Lond) (2009) 1.59

Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes (2009) 1.58

CD11c expression in adipose tissue and blood and its role in diet-induced obesity. Arterioscler Thromb Vasc Biol (2009) 1.57

CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes (2012) 1.56

Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem (2008) 1.55

Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol (2011) 1.53

Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes (2008) 1.52

Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma. Am J Respir Crit Care Med (2015) 1.52

Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1/CCR2 pathway. Circ Res (2012) 1.51

CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue. J Leukoc Biol (2015) 1.49

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ Res (2009) 1.49

Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol (2009) 1.49

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice. J Lipid Res (2009) 1.48

AMPK mediates the initiation of kidney disease induced by a high-fat diet. J Am Soc Nephrol (2011) 1.48

Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia (2008) 1.47

MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med (2009) 1.46

Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr (2012) 1.45

The immune system as a sensor of the metabolic state. Immunity (2013) 1.45

Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes (2010) 1.44

Articles cited by this

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol (2002) 82.19

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54

A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27

Inflammation, stress, and diabetes. J Clin Invest (2005) 17.11

IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (2001) 11.56

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med (2005) 10.88

Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature (1998) 8.92

Adipose tissue, inflammation, and cardiovascular disease. Circ Res (2005) 8.72

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest (1997) 7.58

Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 7.50

Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab (1998) 7.05

Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A (2003) 6.06

Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med (2000) 5.13

Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care (2004) 4.88

Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology (2004) 4.67

Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57

Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med (1997) 4.57

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest (2004) 4.16

Insulin resistance and cardiovascular disease. J Clin Invest (2000) 4.05

Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development (1994) 3.86

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science (2000) 3.75

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes (2005) 3.61

Resistin is an inflammatory marker of atherosclerosis in humans. Circulation (2005) 3.52

Analysis of strain and regional variation in gene expression in mouse brain. Genome Biol (2001) 3.43

Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab (2005) 3.43

Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes (2003) 3.29

From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes (2004) 3.13

The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci U S A (2000) 2.82

Learning gene functional classifications from multiple data types. J Comput Biol (2002) 2.65

An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med (2004) 2.51

Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol Cell Biol (2002) 2.44

Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J Biol Chem (2003) 2.36

Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab (2004) 2.36

Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond) (2005) 2.18

Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes Res (2004) 2.15

Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab (1998) 2.12

Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J Biol Chem (1996) 1.94

Resistin release by human adipose tissue explants in primary culture. Biochem Biophys Res Commun (2003) 1.65

Animal models of nonalcoholic fatty liver disease and steatohepatitis. Clin Liver Dis (2004) 1.53

Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J Immunol (2005) 1.49

Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization. Microcirculation (2003) 1.48

Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord (2004) 1.43

Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes. Int J Exp Diabetes Res (2000) 1.36

Evidence for a link between adipose tissue interleukin-6 content and serum C-reactive protein concentrations in obese subjects. Circulation (1999) 1.31

Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesis. Diabetes Care (1991) 1.31

Articles by these authors

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med (2012) 9.69

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med (2010) 8.77

Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest (2007) 7.02

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83

The long-term stability of the human gut microbiota. Science (2013) 5.15

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood (2010) 4.33

Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03

Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49

Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell (2006) 3.20

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med (2009) 3.07

Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. Mol Microbiol (2010) 2.76

Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76

Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45

Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44

Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab (2013) 2.23

Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Am J Clin Nutr (2007) 2.21

Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr (2008) 2.13

11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99

Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87

C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes (2010) 1.86

Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care (2007) 1.85

Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73

To eat or not to eat - how the gut talks to the brain. N Engl J Med (2003) 1.68

Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica (2013) 1.67

The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. Diabetes Care (2010) 1.66

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum. BMC Genomics (2011) 1.60

A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55

Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49

Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J Immunol (2005) 1.49

Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol (2010) 1.47

Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab (2008) 1.45

Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood (2010) 1.42

Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34

Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians. Diabetes (2008) 1.29

The metamorphosis of supernova SN 2008D/XRF 080109: a link between supernovae and GRBs/hypernovae. Science (2008) 1.28

Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27

Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells. Cancer Biol Ther (2006) 1.23

iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23

Energy intake in weight-reduced humans. Brain Res (2010) 1.21

Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21

Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol Cancer Ther (2010) 1.21

Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. Clin Cancer Res (2007) 1.20

Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J Immunol (2004) 1.19

Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19

β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes (2013) 1.19

Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.17

Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism (2011) 1.17

Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol (2008) 1.13

Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol (2009) 1.12

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12

Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-/- mice. J Leukoc Biol (2006) 1.11

Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet (2008) 1.10

Obesity, inflammation, and macrophages. Nestle Nutr Workshop Ser Pediatr Program (2009) 1.08

Severe retinal degeneration associated with disruption of semaphorin 4A. Invest Ophthalmol Vis Sci (2004) 1.08

Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer (2003) 1.06

Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance. Int J Body Compos Res (2009) 1.03

PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol Reprod Dev (2002) 1.02

Effect of PCR extension temperature on high-throughput sequencing. Mol Biochem Parasitol (2010) 1.01

Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice. Am J Physiol Regul Integr Comp Physiol (2012) 1.01

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo. Mol Cancer Ther (2009) 1.00

Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol (2004) 1.00

Considerations regarding the genetics of obesity. Obesity (Silver Spring) (2008) 1.00

CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma (2014) 0.99

Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab. Cancer Biol Ther (2006) 0.97

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97

Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol (2011) 0.97

Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96

In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96

Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96

The clinical benefit of ruxolitinib across patient subgroups: analysis of a placebo-controlled, Phase III study in patients with myelofibrosis. Br J Haematol (2013) 0.95

Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2. Bioorg Med Chem Lett (2010) 0.95

Roles of the placenta in fetal brain development. Proc Natl Acad Sci U S A (2011) 0.93

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans. Drug Metab Dispos (2007) 0.93

INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support. Neoplasia (2010) 0.93

Macrophages, fat, and the emergence of immunometabolism. J Clin Invest (2013) 0.93

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93

Genomic profiling of left and right ventricular hypertrophy in congenital heart disease. J Card Fail (2008) 0.93

Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest (2015) 0.93

Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics. J Med Chem (2005) 0.92

Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation. J Invest Dermatol (2011) 0.92

Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clin Cancer Res (2002) 0.92

Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos. Reprod Toxicol (2012) 0.92

Validation of standards for quantitative assessment of JAK2 c.1849G>T (p.V617F) allele burden analysis in clinical samples. Genet Test Mol Biomarkers (2013) 0.91