The role of knee alignment in disease progression and functional decline in knee osteoarthritis.

PubWeight™: 7.15‹?› | Rank: Top 1%

🔗 View Article (PMID 11448282)

Published in JAMA on July 11, 2001

Authors

L Sharma1, J Song, D T Felson, S Cahue, E Shamiyeh, D D Dunlop

Author Affiliations

1: Northwestern University Medical School, 303 E Chicago Ave, Ward Bldg 3-315, Chicago, IL 60611, USA. L-Sharma@northwestern.edu

Associated clinical trials:

External Fixator Assisted Genu Varum Correction | NCT03443648

Articles citing this

(truncated to the top 100)

Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann Rheum Dis (2002) 4.89

Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum (2008) 4.50

Epidemiology of osteoarthritis. Clin Geriatr Med (2010) 3.51

Is obesity a risk factor for progressive radiographic knee osteoarthritis? Arthritis Rheum (2009) 2.92

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage (2009) 2.65

A new approach yields high rates of radiographic progression in knee osteoarthritis. J Rheumatol (2008) 2.63

Medial knee osteoarthritis treated by insoles or braces: a randomized trial. Clin Orthop Relat Res (2010) 2.53

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum (2009) 2.24

Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative. Ann Rheum Dis (2008) 1.98

Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis (2006) 1.89

Association of leg-length inequality with knee osteoarthritis: a cohort study. Ann Intern Med (2010) 1.87

Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther (2009) 1.74

Epidemiology of osteoarthritis. Rheum Dis Clin North Am (2008) 1.72

Varus and valgus alignment and incident and progressive knee osteoarthritis. Ann Rheum Dis (2010) 1.70

Control of frontal plane knee laxity during gait in patients with medial compartment knee osteoarthritis. Osteoarthritis Cartilage (2004) 1.62

High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther (2011) 1.62

Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis. Arthritis Rheum (2009) 1.50

Joint space narrowing and Kellgren-Lawrence progression in knee osteoarthritis: an analytic literature synthesis. Osteoarthritis Cartilage (2008) 1.49

Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48

Decreased knee adduction moment does not guarantee decreased medial contact force during gait. J Orthop Res (2010) 1.45

Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage (2012) 1.44

Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc (2011) 1.42

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study. Ann Rheum Dis (2012) 1.42

Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol (2010) 1.40

Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study. Ann Rheum Dis (2011) 1.39

Does the Taylor Spatial Frame accurately correct tibial deformities? Clin Orthop Relat Res (2009) 1.38

Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis. Nat Rev Rheumatol (2010) 1.38

Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative. Arthritis Rheum (2013) 1.37

Osteoarthritis of the spine: the facet joints. Nat Rev Rheumatol (2012) 1.33

Rates of change and sensitivity to change in cartilage morphology in healthy knees and in knees with mild, moderate, and end-stage radiographic osteoarthritis: results from 831 participants from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) (2011) 1.32

The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale. BMC Musculoskelet Disord (2009) 1.29

Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study. Arthritis Rheum (2009) 1.28

Reliability of lower limb alignment measures using an established landmark-based method with a customized computer software program. Rheumatol Int (2009) 1.24

High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study. Ann Rheum Dis (2010) 1.23

The Knee Clinical Assessment Study-CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population: baseline recruitment and retention at 18 months. BMC Musculoskelet Disord (2006) 1.23

Exercise and osteoarthritis. J Anat (2009) 1.19

Relationships of fear, anxiety, and depression with physical function in patients with knee osteoarthritis. Arch Phys Med Rehabil (2009) 1.18

Does measurement of the anatomic axis consistently predict hip-knee-ankle angle (HKA) for knee alignment studies in osteoarthritis? Analysis of long limb radiographs from the multicenter osteoarthritis (MOST) study. Osteoarthritis Cartilage (2010) 1.17

MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches using MRI or radiography--data from the OA initiative. Osteoarthritis Cartilage (2011) 1.17

The relationship between toe-out angle during gait and progression of medial tibiofemoral osteoarthritis. Ann Rheum Dis (2007) 1.15

Predicting poor functional outcome in community-dwelling older adults with knee pain: prognostic value of generic indicators. Ann Rheum Dis (2007) 1.14

Association of bone scintigraphic abnormalities with knee malalignment and pain. Ann Rheum Dis (2008) 1.14

Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study. Ann Rheum Dis (2009) 1.12

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow. Arthritis Res Ther (2006) 1.11

Progression of osteoarthritis as a state of inertia. Ann Rheum Dis (2012) 1.11

Boomerang proximal tibial osteotomy for the treatment of severe varus gonarthrosis. Int Orthop (2013) 1.10

Can anatomic alignment measured from a knee radiograph substitute for mechanical alignment from full limb films? Osteoarthritis Cartilage (2009) 1.09

Factors that may mediate the relationship between physical activity and the risk for developing knee osteoarthritis. Arthritis Res Ther (2008) 1.08

Retrograde dynamic locked nailing for valgus knee correction: a revised technique. Int Orthop (2012) 1.07

Association of flat feet with knee pain and cartilage damage in older adults. Arthritis Care Res (Hoboken) (2011) 1.05

Relationship of limb length inequality with radiographic knee and hip osteoarthritis. Osteoarthritis Cartilage (2007) 1.04

Muscle dysfunction versus wear and tear as a cause of exercise related osteoarthritis: an epidemiological update. Br J Sports Med (2004) 1.04

Gait after unilateral total knee arthroplasty: frontal plane analysis. J Orthop Res (2010) 1.04

Medial posterior meniscal root tears are associated with development or worsening of medial tibiofemoral cartilage damage: the multicenter osteoarthritis study. Radiology (2013) 1.02

Knee joint forces: prediction, measurement, and significance. Proc Inst Mech Eng H (2012) 1.02

Knee alignment differences between Chinese and Caucasian subjects without osteoarthritis. Ann Rheum Dis (2008) 1.01

Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage (2014) 1.00

Instability, laxity, and physical function in patients with medial knee osteoarthritis. Phys Ther (2008) 1.00

Risk factors for progression of tibiofemoral osteoarthritis: an analysis based on fluoroscopically standardised knee radiography. Ann Rheum Dis (2005) 0.99

Evaluation of a new low-dose biplanar system to assess lower-limb alignment in 3D: a phantom study. Skeletal Radiol (2012) 0.99

Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis. Osteoarthritis Cartilage (2010) 0.98

Can cartilage loss be detected in knee osteoarthritis (OA) patients with 3-6 months' observation using advanced image analysis of 3T MRI? Osteoarthritis Cartilage (2010) 0.98

What Are the Prognostic Factors for Radiographic Progression of Knee Osteoarthritis? A Meta-analysis. Clin Orthop Relat Res (2015) 0.98

The Relationship Between Lower Extremity Alignment Characteristics and Anterior Knee Joint Laxity. Sports Health (2009) 0.97

Varus distal femoral osteotomy in young adults with valgus knee. J Orthop Surg Res (2009) 0.97

Two-year incidence and predictors of future knee arthroplasty in persons with symptomatic knee osteoarthritis: preliminary analysis of longitudinal data from the osteoarthritis initiative. Knee (2009) 0.97

Meniscal damage associated with increased local subchondral bone mineral density: a Framingham study. Osteoarthritis Cartilage (2007) 0.97

A cadaver study comparing intraoperative methods to analyze lower limb alignment. Skeletal Radiol (2014) 0.97

Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement--a potential target for prevention of knee osteoarthritis: a longitudinal study. Arthritis Res Ther (2010) 0.96

Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study. Ann Rheum Dis (2012) 0.96

Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years. Arthritis Res Ther (2006) 0.96

Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months. Osteoarthritis Cartilage (2012) 0.95

Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI. Osteoarthritis Cartilage (2013) 0.94

Clinical significance of bone changes in osteoarthritis. Ther Adv Musculoskelet Dis (2012) 0.94

Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo. Arthritis Res Ther (2013) 0.93

Relationship between knee and ankle degeneration in a population of organ donors. BMC Med (2010) 0.93

A comparison of five approaches to measurement of anatomic knee alignment from radiographs. Osteoarthritis Cartilage (2009) 0.93

T1rho mapping of entire femoral cartilage using depth- and angle-dependent analysis. Eur Radiol (2015) 0.93

Constitutional varus does not affect joint line orientation in the coronal plane. Clin Orthop Relat Res (2014) 0.93

Static knee alignment measurements among Caucasians and African Americans: the Johnston County Osteoarthritis Project. J Rheumatol (2009) 0.92

Opening- and Closing-Wedge Distal Femoral Osteotomy: A Systematic Review of Outcomes for Isolated Lateral Compartment Osteoarthritis. Orthop J Sports Med (2016) 0.92

Risk factors for incident osteoarthritis of the hip and knee. Curr Rev Musculoskelet Med (2011) 0.92

Effectiveness of exercise for osteoarthritis of the knee: A review of the literature. World J Orthop (2011) 0.92

Associations of varus thrust and alignment with pain in knee osteoarthritis. Arthritis Rheum (2012) 0.92

Comparison of neuromuscular and quadriceps strengthening exercise in the treatment of varus malaligned knees with medial knee osteoarthritis: a randomised controlled trial protocol. BMC Musculoskelet Disord (2011) 0.92

Foot rotational effects on radiographic measures of lower limb alignment. Can J Surg (2006) 0.91

Relationship between accelerometer-based measures of physical activity and the Yale Physical Activity Survey in adults with arthritis. Arthritis Care Res (Hoboken) (2011) 0.91

Deformity correction in children with hereditary hypophosphatemic rickets. Clin Orthop Relat Res (2008) 0.91

Acupuncture for pain and osteoarthritis of the knee: a pilot study for an open parallel-arm randomised controlled trial. BMC Musculoskelet Disord (2009) 0.90

Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis? Eur Radiol (2009) 0.90

Excess body weight and four-year function outcomes: comparison of African Americans and whites in a prospective study of osteoarthritis. Arthritis Care Res (Hoboken) (2013) 0.90

Synovitis and the risk of knee osteoarthritis: the MOST Study. Osteoarthritis Cartilage (2015) 0.89

Are external knee load and EMG measures accurate indicators of internal knee contact forces during gait? J Orthop Res (2012) 0.89

Frontal knee alignment: three-dimensional marker positions and clinical assessment. Clin Orthop Relat Res (2008) 0.88

Knee confidence as it relates to physical function outcome in persons with or at high risk of knee osteoarthritis in the osteoarthritis initiative. Arthritis Rheum (2012) 0.88

Effect of local alignment on compartmental patterns of knee osteoarthritis. J Bone Joint Surg Am (2008) 0.88

Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study. Osteoarthritis Cartilage (2010) 0.88

Quantitative analysis of subchondral sclerosis of the tibia by bone texture parameters in knee radiographs: site-specific relationships with joint space width. Osteoarthritis Cartilage (2009) 0.88

Digital radiographic assessment of tibiofemoral joint space width: a variance component analysis. J Knee Surg (2009) 0.87

Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change? Osteoarthritis Cartilage (2009) 0.87

Articles by these authors

Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum (1998) 12.36

The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1987) 9.24

The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18

The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38

Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA (2000) 6.54

Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol (1988) 6.34

Guided medication dosing for inpatients with renal insufficiency. JAMA (2001) 6.25

Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (2001) 6.23

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J Virol (1993) 6.11

Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum (1997) 5.57

A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis. Arch Intern Med (1994) 5.04

Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis. Arthritis Rheum (2001) 4.57

Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites. Mol Biol Cell (1996) 4.37

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell (1995) 4.25

Bone mass and the risk of breast cancer among postmenopausal women. N Engl J Med (1997) 3.96

Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum (1995) 3.89

Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol. J Natl Cancer Inst (2001) 3.88

Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol (2000) 3.63

The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum (2006) 3.51

Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res (2000) 3.09

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity (2001) 3.08

Hip fracture and the use of estrogens in postmenopausal women. The Framingham Study. N Engl J Med (1987) 3.00

Is obesity a risk factor for progressive radiographic knee osteoarthritis? Arthritis Rheum (2009) 2.92

Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration. Arthritis Rheum (2000) 2.92

Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis. Arthritis Rheum (1998) 2.89

Change in joint space width: hyaline articular cartilage loss or alteration in meniscus? Arthritis Rheum (2006) 2.80

Localization of endoplasmic reticulum in living and glutaraldehyde-fixed cells with fluorescent dyes. Cell (1984) 2.73

Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation (2001) 2.70

Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology (1999) 2.69

Laxity in healthy and osteoarthritic knees. Arthritis Rheum (1999) 2.68

Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis. J Rheumatol (2001) 2.59

ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials. American College of Rheumatology European League of Associations for Rheumatology. J Rheumatol (1999) 2.58

Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum (2001) 2.45

Local and nonlocal curvature elasticity in bilayer membranes by tether formation from lecithin vesicles. Biophys J (1992) 2.34

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage (2006) 2.27

Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis. Ann Rheum Dis (2008) 2.27

Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med (1996) 2.24

World Health Organization and International League of Associations for Rheumatology core endpoints for symptom modifying antirheumatic drugs in rheumatoid arthritis clinical trials. J Rheumatol Suppl (1994) 2.23

Prevalence of foot and ankle conditions in a multiethnic community sample of older adults. Am J Epidemiol (2004) 2.20

Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit). Mol Cell Biol (1996) 2.20

The mechanism of the effect of obesity in knee osteoarthritis: the mediating role of malalignment. Arthritis Rheum (2000) 2.18

Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample. Am J Clin Nutr (1997) 2.18

Retrograde transport of Golgi-localized proteins to the ER. J Cell Biol (1998) 2.08

Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation (2000) 2.07

The lag time between onset of symptoms and diagnosis of rheumatoid arthritis. Arthritis Rheum (1994) 2.06

The 18-month impact of an emergency room intervention for adolescent female suicide attempters. J Consult Clin Psychol (2000) 2.05

Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study. Ann Intern Med (2000) 2.02

Toward cataloguing all rice genes: large-scale sequencing of randomly chosen rice cDNAs from a callus cDNA library. Plant J (1994) 2.02

Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.99

Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol (2000) 1.94

Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res (2000) 1.94

Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci (1998) 1.92

The efficacy of home based progressive strength training in older adults with knee osteoarthritis: a randomized controlled trial. J Rheumatol (2001) 1.88

Which traditional measures should be used in rheumatoid arthritis clinical trials? Arthritis Rheum (1989) 1.85

End-of-life decision making: when patients and surrogates disagree. J Clin Ethics (1999) 1.83

Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study. Am J Med (1999) 1.83

Caffeine and the risk of hip fracture: the Framingham Study. Am J Epidemiol (1990) 1.81

Retrotransposon-related DNA sequences in the centromeres of grass chromosomes. Genetics (1998) 1.80

A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure. Arch Intern Med (1993) 1.68

Arthritis prevalence and activity limitations in older adults. Arthritis Rheum (2001) 1.65

Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness. Arthritis Rheum (2007) 1.64

Musculoskeletal disease research: should we analyze the joint or the person? J Rheumatol (1996) 1.63

Across-study evaluation of association between steroid dose and bolus steroids and avascular necrosis of bone. Lancet (1987) 1.63

The effect of alendronate on progression of spinal osteophytes and disc-space narrowing. Ann Rheum Dis (2008) 1.61

The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development (1999) 1.59

Defining arthritis and measuring functional status in elders: methodological issues in the study of disease and physical disability. Am J Public Health (1990) 1.58

On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem (1997) 1.57

Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum (1996) 1.56

Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort. Osteoarthritis Cartilage (2010) 1.56

Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol (2001) 1.56

High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter. Biochemistry (2001) 1.56

Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins. Cell Motil Cytoskeleton (2001) 1.55

Relation of synovitis to knee pain using contrast-enhanced MRIs. Ann Rheum Dis (2010) 1.55

Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG. Mol Microbiol (2001) 1.53

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. J Virol (1997) 1.52

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J (2001) 1.50

The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach. Arthritis Rheum (1999) 1.50

p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev (1998) 1.50

Bone mineral density and knee osteoarthritis in elderly men and women. The Framingham Study. Arthritis Rheum (1993) 1.48

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48

A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis Rheum (1986) 1.48

Patient preferences for treatment of rheumatoid arthritis. Ann Rheum Dis (2004) 1.47

The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. Acta Physiol (Oxf) (2014) 1.44

Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation (2000) 1.43

The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J Biol Chem (1999) 1.43

Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. FEBS Lett (1999) 1.42

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol (2000) 1.41

Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: Results from a prospective multinational study. Arthritis Care Res (Hoboken) (2012) 1.40

Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster. Proc Natl Acad Sci U S A (1994) 1.40

In vivo cartilage contact deformation in the healthy human tibiofemoral joint. Rheumatology (Oxford) (2008) 1.39

Low serum concentrations of anti-tuberculosis drugs and determinants of their serum levels. Int J Tuberc Lung Dis (2007) 1.37

A massive, cooling-flow-induced starburst in the core of a luminous cluster of galaxies. Nature (2012) 1.36

Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. J Bacteriol (1998) 1.36

Lifetime and novel psychiatric disorders after pediatric traumatic brain injury. J Am Acad Child Adolesc Psychiatry (2001) 1.36

Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime. NMR Biomed (2008) 1.35

Bone mineral density in elderly men and women: results from the Framingham osteoporosis study. J Bone Miner Res (1992) 1.34