Succinate is the controller of O2-/H2O2 release at mitochondrial complex I : negative modulation by malate, positive by cyanide.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 19821037)

Published in J Bioenerg Biomembr on October 10, 2009

Authors

Franco Zoccarato1, Lucia Cavallini, Adolfo Alexandre

Author Affiliations

1: Dipartimento di Chimica Biologica, Università di Padova, Viale Giuseppe Colombo 3, 35131, Padova, Italy.

Articles cited by this

The pathobiology of diabetic complications: a unifying mechanism. Diabetes (2005) 14.96

How mitochondria produce reactive oxygen species. Biochem J (2009) 13.03

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature (2000) 12.33

Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33

The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85

Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36

Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev (2008) 4.14

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science (2007) 3.92

Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem (2006) 3.88

Respiratory active mitochondrial supercomplexes. Mol Cell (2008) 3.35

The role of mitochondria in reactive oxygen species metabolism and signaling. Ann N Y Acad Sci (2008) 2.27

Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney. J Clin Invest (2008) 1.72

Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A (2006) 1.72

Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB J (2007) 1.60

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J (2008) 1.44

Influence of complete ischemia on glycolytic metabolites, citric acid cycle intermediates, and associated amino acids in the rat cerebral cortex. Brain Res (1974) 1.41

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB J (2001) 1.41

Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Radic Biol Med (2002) 1.37

Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci U S A (2004) 1.34

Respiration-dependent removal of exogenous H2O2 in brain mitochondria: inhibition by Ca2+. J Biol Chem (2003) 1.32

Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Cancer Res (2006) 1.17

Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling. Am J Physiol Cell Physiol (2006) 1.16

Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction. Exp Gerontol (2004) 1.08

Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling. Proc Natl Acad Sci U S A (2002) 1.07

Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state. FEBS Lett (2008) 1.04

Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease. J Biol Chem (2005) 1.03

Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state. Biochim Biophys Acta (2006) 1.00

Succinate in dystrophic white matter: a proton magnetic resonance spectroscopy finding characteristic for complex II deficiency. Ann Neurol (2002) 1.00

Succinate modulation of H2O2 release at NADH:ubiquinone oxidoreductase (Complex I) in brain mitochondria. Biochem J (2007) 0.98

Multiplet structure of 13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediates. Magn Reson Med (1996) 0.95

Tightly bound oxalacetate and the activation of succinate dehydrogenase. Biochem Biophys Res Commun (1972) 0.93

Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide. J Cell Sci (2006) 0.91

Ischemia and aging brain. Studies on glucose and energy metabolism in rat cerebral cortex. Neurobiol Aging (1986) 0.86

Long chain fatty acyl-CoA modulation of H(2)O (2) release at mitochondrial complex I. J Bioenerg Biomembr (2008) 0.81

Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H(2)O(2) release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J Bioenerg Biomembr (2008) 0.79

Articles by these authors

Respiration-dependent removal of exogenous H2O2 in brain mitochondria: inhibition by Ca2+. J Biol Chem (2003) 1.32

Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma. Biochem Pharmacol (2010) 1.18

Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease. J Biol Chem (2005) 1.03

Succinate modulation of H2O2 release at NADH:ubiquinone oxidoreductase (Complex I) in brain mitochondria. Biochem J (2007) 0.98

Long chain fatty acyl-CoA modulation of H(2)O (2) release at mitochondrial complex I. J Bioenerg Biomembr (2008) 0.81

Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain (2007) 0.81

Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H(2)O(2) release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J Bioenerg Biomembr (2008) 0.79

Pericentriolar material analyses in normal esophageal mucosa, Barrett's metaplasia and adenocarcinoma. Histol Histopathol (2010) 0.79

Comparison of temsirolimus pharmacokinetics in patients with renal cell carcinoma not receiving dialysis and those receiving hemodialysis: a case series. Clin Ther (2009) 0.79

Temsirolimus in patients with renal cancer on hemodialysis. J Clin Oncol (2008) 0.78

Primary cutaneous plasmacytoma after rejection of a transplanted kidney: case report and review of the literature. Int J Hematol (2004) 0.78

[The role of the patient in handling long-term treatment. From compliance to adherence]. G Ital Nefrol (2010) 0.75

Different effects of SNP and GSNO on mitochondrial O2 .- /H 2O2 production. J Bioenerg Biomembr (2011) 0.75

The control of mitochondrial succinate-dependent H2O2 production. J Bioenerg Biomembr (2011) 0.75

Enhanced detection of H2O2 in cells expressing horseradish peroxidase. Free Radic Res (2009) 0.75