Published in Proc Natl Acad Sci U S A on October 22, 2009
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Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci (2010) 1.69
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A novel role for FOXA2 and SHH in organizing midbrain signaling centers. Dev Biol (2012) 0.82
Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus. Endocrinology (2011) 0.82
Sonic hedgehog signaling in the development of the mouse hypothalamus. Front Neuroanat (2015) 0.81
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Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J Comp Neurol (2011) 0.80
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Molecular heterogeneity of midbrain dopaminergic neurons - Moving toward single cell resolution. FEBS Lett (2015) 0.78
CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. PLoS One (2014) 0.78
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Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev (2013) 0.78
Detailed expression analysis of regulatory genes in the early developing human neural tube. Stem Cells Dev (2013) 0.77
Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Mol Cell Neurosci (2015) 0.76
Mesencephalic origin of the rostral Substantia nigra pars reticulata. Brain Struct Funct (2015) 0.76
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development (2017) 0.75
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Tracing lineages to uncover neuronal identity. BMC Biol (2011) 0.75
Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog. Front Neuroanat (2015) 0.75
Making a mes: A transcription factor-microRNA pair governs the size of the midbrain and the dopaminergic progenitor pool. Neurogenesis (Austin) (2015) 0.75
Embryonic development of selectively vulnerable neurons in Parkinson's disease. NPJ Parkinsons Dis (2017) 0.75
Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. Cell Tissue Res (2017) 0.75
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
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Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature (2002) 6.51
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Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain (2005) 3.61
Identification of intrinsic determinants of midbrain dopamine neurons. Cell (2006) 3.31
Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron (2004) 2.93
The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol (2007) 2.54
Genetic inducible fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system. Dev Dyn (2006) 2.51
How to make a mesodiencephalic dopaminergic neuron. Nat Rev Neurosci (2007) 2.33
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci (2000) 2.20
Redefining the serotonergic system by genetic lineage. Nat Neurosci (2008) 2.15
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development (1998) 2.08
Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci (2009) 2.03
Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development (2007) 2.01
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Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development (2004) 1.86
Transcriptional control of midbrain dopaminergic neuron development. Development (2006) 1.74
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain Res Mol Brain Res (2003) 1.66
Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes Dev (2003) 1.60
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Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development (2007) 1.50
Molecular basis for catecholaminergic neuron diversity. Proc Natl Acad Sci U S A (2004) 1.47
Therapeutic cloning in individual parkinsonian mice. Nat Med (2008) 1.46
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A (2006) 1.26
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Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci (2003) 1.19
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci (2007) 1.17
Ligand-activated Flpe for temporally regulated gene modifications. Genesis (2005) 1.12
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (2009) 1.11
A role for midbrain arcs in nucleogenesis. Development (2002) 1.08
Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis. Exp Neurol (2009) 1.06
Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors. Glia (2008) 1.06
Future of cell and gene therapies for Parkinson's disease. Ann Neurol (2008) 0.92
Will stem cell biology generate new therapies for Parkinson's disease? Neuron (2008) 0.88
Notch signalling regulates stem cell numbers in vitro and in vivo. Nature (2006) 5.49
Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci (2009) 2.03
Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. Am J Hum Genet (2004) 1.70
Plasticity, niches, and the use of stem cells. Dev Cell (2002) 1.36
Role of neurotrophins in central synapse formation and stabilization. Nat Rev Neurosci (2002) 1.27
MicroRNA-deficient Schwann cells display congenital hypomyelination. J Neurosci (2010) 1.19
Genetic and physiological evidence that oligodendrocyte gap junctions contribute to spatial buffering of potassium released during neuronal activity. J Neurosci (2006) 1.18
Chylothorax following innominate vein thrombosis: a rare complication of transvenous pacemaker implantation. Respiration (2005) 0.96
Unwrapping myelination by microRNAs. Neuroscientist (2011) 0.94
Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate. PLoS One (2012) 0.90
Regulation of murine TGFbeta2 by Pax3 during early embryonic development. J Biol Chem (2006) 0.89
Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis. J Mol Cell Biol (2013) 0.89
Will stem cell biology generate new therapies for Parkinson's disease? Neuron (2008) 0.88
Generating CNS neurons from embryonic, fetal, and adult stem cells. Methods Enzymol (2003) 0.86
Distinct roles of microRNAs in epithelium and mesenchyme during tooth development. Dev Dyn (2012) 0.84
Genetic variation in FGF20 modulates hippocampal biology. J Neurosci (2010) 0.83
Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci (2013) 0.83
The bimusical brain is not two monomusical brains in one: evidence from musical affective processing. J Cogn Neurosci (2011) 0.81
Transcriptional regulation by Pax3 and TGFbeta2 signaling: a potential gene regulatory network in neural crest development. Int J Dev Biol (2009) 0.79
A randomized controlled trial to assess the clinical and cost effectiveness of a nurse-led Antenatal Asthma Management Service in South Australia (AAMS study). BMC Pregnancy Childbirth (2014) 0.77
From stem cells to dopamine neurons: developmental biology meets neurodegeneration. CNS Neurol Disord Drug Targets (2012) 0.76
Abdominal complications following posterior spinal fusion in patients with previous abdominal surgeries. Neurosurg Focus (2011) 0.76
Review: long acting beta agonists increase severe asthma exacerbations and asthma related deaths in children and adults. Evid Based Med (2007) 0.75
Provisional hypotheses for the molecular genetics of cognitive development: imaging genetic pathways in the anterior cingulate cortex. Biol Psychol (2007) 0.75
Review: long-acting beta-agonists increase severe asthma exacerbations and asthma-related deaths in children and adults. ACP J Club (2007) 0.75
Chylothorax following innominate vein thrombosis--a rare complication of transvenous pacemaker implantation. Respiration (2007) 0.75
Prevalence of bronchial asthma among bank employees of Vellore using questionnaire-based data. J Indian Med Assoc (2002) 0.75