Published in Development on March 01, 2004
Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells (2005) 3.38
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A (2006) 1.69
Animal models of Parkinson's disease progression. Acta Neuropathol (2008) 1.49
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. Proc Natl Acad Sci U S A (2009) 1.37
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A (2006) 1.26
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat Neurosci (2010) 1.22
Clinical and experimental advances in congenital and paediatric cataracts. Philos Trans R Soc Lond B Biol Sci (2011) 1.20
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One (2008) 1.14
Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development. BMC Dev Biol (2007) 1.08
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development (2009) 1.08
Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biol (2010) 1.07
Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Mol Ther (2009) 1.06
Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson's disease. Neurobiol Dis (2007) 0.99
Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells. Mol Brain (2008) 0.96
Onset of Pup Locomotion Coincides with Loss of NR2C/D-Mediated Cortico-Striatal EPSCs and Dampening of Striatal Network Immature Activity. Front Cell Neurosci (2011) 0.94
Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. J Neurochem (2009) 0.93
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome (2009) 0.89
Expression and subcellular location of alpha-synuclein during mouse-embryonic development. Cell Mol Neurobiol (2009) 0.88
Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway. Neuropsychopharmacology (2008) 0.88
Development and function of the midbrain dopamine system: what we know and what we need to. Genes Brain Behav (2015) 0.87
The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. J Biomed Sci (2014) 0.87
Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open (2012) 0.86
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO J (2016) 0.86
Induced neuronal reprogramming. J Comp Neurol (2014) 0.85
The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease. Curr Top Med Chem (2009) 0.85
Molecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons. PLoS One (2013) 0.84
Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson's disease, the aphakia (ak) mouse. Cell Transplant (2012) 0.84
Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells. J Biol Chem (2009) 0.83
Parallel dopamine D1 receptor activity dependence of l-Dopa-induced normal movement and dyskinesia in mice. Neuroscience (2013) 0.83
Motor deficits and altered striatal gene expression in aphakia (ak) mice. Brain Res (2007) 0.82
Strategies to unravel molecular codes essential for the development of meso-diencephalic dopaminergic neurons. J Physiol (2006) 0.82
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. Hum Mol Genet (2015) 0.82
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood. ACS Chem Neurosci (2015) 0.81
Midbrain dopaminergic development in vivo and in vitro from embryonic stem cells. J Anat (2005) 0.81
Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons. Stem Cell Reports (2014) 0.81
Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling. PLoS One (2014) 0.80
Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2. PLoS One (2013) 0.79
Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain. Development (2012) 0.78
Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model. PLoS One (2012) 0.78
Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein. Mol Vis (2012) 0.78
The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Dev (2012) 0.78
Molecular heterogeneity of midbrain dopaminergic neurons - Moving toward single cell resolution. FEBS Lett (2015) 0.78
Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Brain Res (2012) 0.78
Pitx3 deficiency produces decreased dopamine signaling and induces motor deficits in Pitx3(-/-) mice. Neurobiol Aging (2015) 0.77
Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice. J Neurophysiol (2013) 0.77
Phox2b influences the development of a caudal dopaminergic subset. PLoS One (2012) 0.77
Differential expression of the FMRF gene in adult and hatchling stellate ganglia of the squid Loligo pealei. Biol Open (2014) 0.77
Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons. Mol Neurobiol (2016) 0.76
Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. PLoS One (2013) 0.76
L-dopa reverses behavioral deficits in the Pitx3 mouse fetus. Behav Neurosci (2014) 0.76
Potential sources of stem cells as a regenerative therapy for Parkinson's disease. Stem Cells Cloning (2010) 0.76
Nucleotide sequence conservation of novel and established cis-regulatory sites within the tyrosine hydroxylase gene promoter. Front Biol (Beijing) (2015) 0.76
Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson's Disease. Sci Rep (2016) 0.76
Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons. J Cell Mol Med (2012) 0.76
The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei. Biol Open (2015) 0.75
Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nat Commun (2016) 0.75
Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum. J Neurophysiol (2016) 0.75
Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset. Front Mol Neurosci (2017) 0.75
A passport to neurotransmitter identity. Genome Biol (2009) 0.75
Improvement of neurological dysfunctions in aphakia mice, a model of Parkinson's disease, after transplantation of ES cell-derived dopaminergic neuronal precursors. Methods Mol Biol (2014) 0.75
No apparent transmission of transgenic α-synuclein into nigrostriatal dopaminergic neurons in multiple mouse models. Transl Neurodegener (2015) 0.75
Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets. Front Neuroanat (2017) 0.75
Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool. PLoS One (2017) 0.75
Embryonic development of selectively vulnerable neurons in Parkinson's disease. NPJ Parkinsons Dis (2017) 0.75
Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line. Cell Tissue Res (2017) 0.75
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology (2017) 0.75
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell (2009) 3.63
U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. J Nucl Med (2005) 3.01
Copy-number variation in sporadic amyotrophic lateral sclerosis: a genome-wide screen. Lancet Neurol (2008) 2.54
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem (2003) 2.50
How to make a mesodiencephalic dopaminergic neuron. Nat Rev Neurosci (2007) 2.33
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci U S A (2006) 2.24
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol (2005) 2.22
Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J Neurotrauma (2006) 2.14
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods (2005) 1.93
Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One (2010) 1.66
Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice. Exp Neurol (2005) 1.65
Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development (2004) 1.53
Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns (2005) 1.52
The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination. J Neurotrauma (2005) 1.52
In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50
On the use of Tono-Pen XL for the measurement of intraocular pressure in mice. Exp Eye Res (2005) 1.49
Sub-chronic toxicity study in rats orally exposed to nanostructured silica. Part Fibre Toxicol (2014) 1.44
Mouse phenotyping. Methods (2010) 1.43
CRYBA4, a novel human cataract gene, is also involved in microphthalmia. Am J Hum Genet (2006) 1.41
Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra. Cell Tissue Res (2004) 1.37
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J (2002) 1.35
Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano (2012) 1.34
FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling. Biochem J (2005) 1.31
Using the CatWalk method to assess weight-bearing and pain behaviour in walking rats with ankle joint monoarthritis induced by carrageenan: effects of morphine and rofecoxib. J Neurosci Methods (2008) 1.26
Systemic first-line phenotyping. Methods Mol Biol (2009) 1.26
Presence and risks of nanosilica in food products. Nanotoxicology (2010) 1.25
Mutation analysis of congenital cataracts in Indian families: identification of SNPS and a new causative allele in CRYBB2 gene. Invest Ophthalmol Vis Sci (2004) 1.25
Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur J Neurosci (2003) 1.24
Mouse mutants as models for congenital retinal disorders. Exp Eye Res (2005) 1.23
Gene-network analysis identifies susceptibility genes related to glycobiology in autism. PLoS One (2009) 1.23
Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family. Mol Vis (2006) 1.22
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development (2009) 1.21
Social Responsiveness Scale-aided analysis of the clinical impact of copy number variations in autism. Neurogenetics (2011) 1.21
Clinical and experimental advances in congenital and paediatric cataracts. Philos Trans R Soc Lond B Biol Sci (2011) 1.20
Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci (2009) 1.19
Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development (2007) 1.18
Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome. Brain Res (2004) 1.16
Presence of nano-sized silica during in vitro digestion of foods containing silica as a food additive. ACS Nano (2012) 1.15
Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur J Neurosci (2005) 1.15
Strain and locomotor speed affect over-ground locomotion in intact rats. Physiol Behav (2007) 1.14
Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration. BMC Dev Biol (2007) 1.12
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A (2002) 1.11
Contactins in the neurobiology of autism. Eur J Pharmacol (2013) 1.11
Developmental origin and fate of meso-diencephalic dopamine neurons. Prog Neurobiol (2006) 1.10
Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome (2012) 1.09
Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model. Mol Vis (2012) 1.09
Variations of eye size parameters among different strains of mice. Mamm Genome (2006) 1.09
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development (2009) 1.08
Recessive transmission of a multiple endocrine neoplasia syndrome in the rat. Cancer Res (2002) 1.07
A co-segregating microduplication of chromosome 15q11.2 pinpoints two risk genes for autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet (2010) 1.06
A novel GJA8 mutation causing a recessive triangular cataract. Mol Vis (2008) 1.06
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. J Biol Chem (2011) 1.05
PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. Dev Dyn (2002) 1.05
Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization. Eur Neuropsychopharmacol (2005) 1.04
Characterization of titanium dioxide nanoparticles in food products: analytical methods to define nanoparticles. J Agric Food Chem (2014) 1.04
Locomotor recovery after spinal cord contusion injury in rats is improved by spontaneous exercise. J Neurotrauma (2003) 1.03
Relative roles of the different Pax6 domains for pancreatic alpha cell development. BMC Dev Biol (2010) 1.02
"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour? Front Biosci (2008) 1.01
Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. J Neurosci (2008) 1.01
An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Mol Vis (2005) 1.01
Molecular analysis of cataract families in India: new mutations in the CRYBB2 and GJA3 genes and rare polymorphisms. Mol Vis (2010) 1.00
Mutation analysis in a German family identified a new cataract-causing allele in the CRYBB2 gene. Mol Vis (2007) 0.98
Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons. Development (2011) 0.98
Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development (2013) 0.96
Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat. J Neurotrauma (2006) 0.96
Molecular mechanisms underlying midbrain dopamine neuron development and function. Eur J Pharmacol (2003) 0.94
Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice. Eur J Neurosci (2003) 0.94
Ataxia with loss of Purkinje cells in a mouse model for Refsum disease. Proc Natl Acad Sci U S A (2008) 0.94
Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse. Invest Ophthalmol Vis Sci (2009) 0.94
Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions. Eur J Neurosci (2006) 0.94
Contactins: structural aspects in relation to developmental functions in brain disease. Adv Protein Chem Struct Biol (2011) 0.93
Knowledge gaps in risk assessment of nanosilica in food: evaluation of the dissolution and toxicity of different forms of silica. Nanotoxicology (2012) 0.92
Homeobox gene expression in adult dorsal root ganglia during sciatic nerve regeneration: is regeneration a recapitulation of development? Eur J Pharmacol (2003) 0.92
Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Mol Cell Neurosci (2005) 0.92
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS One (2012) 0.92
Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy. Int J Cancer (2009) 0.91
Novel allele of crybb2 in the mouse and its expression in the brain. Invest Ophthalmol Vis Sci (2008) 0.91
Activity-based therapies to promote forelimb use after a cervical spinal cord injury. J Neurotrauma (2009) 0.91
Electroretinography as a screening method for mutations causing retinal dysfunction in mice. Invest Ophthalmol Vis Sci (2004) 0.91
Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype. Invest Ophthalmol Vis Sci (2008) 0.90
First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts. Invest Ophthalmol Vis Sci (2011) 0.90
A novel human CRYGD mutation in a juvenile autosomal dominant cataract. Mol Vis (2010) 0.90
Agonistic and antagonistic action of AP2, Msx2, Pax6, Prox1 AND Six3 in the regulation of Sox2 expression. Ophthalmic Res (2005) 0.89
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome (2009) 0.89
Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model. Nanotoxicology (2012) 0.89