Published in BMC Mol Biol on October 28, 2009
Targeted gene therapies: tools, applications, optimization. Crit Rev Biochem Mol Biol (2012) 0.91
Genetic diversification by somatic gene conversion. Genes (Basel) (2011) 0.84
Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network. PLoS One (2012) 0.78
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature (2005) 19.15
An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol (2007) 17.80
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol (2007) 8.88
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature (2002) 7.12
In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. J Cell Biol (1996) 6.78
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature (2002) 4.89
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A (2003) 4.89
A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell (1987) 4.23
Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Mol Cell Biol (2001) 4.19
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat Immunol (2003) 3.81
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 3.58
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature (2001) 3.09
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science (2002) 3.04
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J (1999) 2.66
The Rad51 paralog Rad51B promotes homologous recombinational repair. Mol Cell Biol (2000) 2.39
Light chain gene conversion continues at high rate in an ALV-induced cell line. EMBO J (1990) 2.28
Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast. Mol Cell (2003) 2.17
Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell (1987) 2.15
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Immunoglobulin gene diversification. Annu Rev Genet (2005) 2.00
AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr Biol (2002) 1.98
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
In vivo visualization of chromosomes using lac operator-repressor binding. Trends Cell Biol (1998) 1.64
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol (2004) 1.56
Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) (2004) 1.51
MutSalpha binds to and promotes synapsis of transcriptionally activated immunoglobulin switch regions. Curr Biol (2005) 1.45
MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Mol Cell (2005) 1.43
Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line. Dev Dyn (2004) 1.36
Coordinated response of mammalian Rad51 and Rad52 to DNA damage. EMBO Rep (2000) 1.35
Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Mol Cell Biol (2005) 1.33
Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations. J Immunol (2006) 1.27
Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage. Curr Biol (1999) 1.23
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur J Immunol (2004) 1.23
Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity. Genes Dev (1990) 1.22
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. Nat Immunol (2005) 1.20
Chromatin structure regulates gene conversion. PLoS Biol (2007) 1.12
Homologous recombination is required for AAV-mediated gene targeting. Nucleic Acids Res (2006) 1.11
A look to future directions in gene therapy research for monogenic diseases. PLoS Genet (2006) 1.11
Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes. PLoS Genet (2009) 1.05
Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting. Nucleic Acids Res (2008) 1.04
Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line. Nucleic Acids Res (2002) 1.03
Immunoglobulin diversification in DT40: a model for vertebrate DNA damage tolerance. DNA Repair (Amst) (2004) 1.02
The chicken B-cell receptor complex and its role in avian B-cell development. Immunol Rev (2000) 0.98
Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells. Genes Cells (2006) 0.94
E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol (2009) 0.92
Temporal regulation of Ig gene diversification revealed by single-cell imaging. J Immunol (2009) 0.91
Potentiation of gene targeting in human cells by expression of Saccharomyces cerevisiae Rad52. Nucleic Acids Res (2005) 0.89
Brca1 in immunoglobulin gene conversion and somatic hypermutation. DNA Repair (Amst) (2007) 0.88
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev (2004) 3.36
Gene function correlates with potential for G4 DNA formation in the human genome. Nucleic Acids Res (2006) 3.13
G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. Nucleic Acids Res (2002) 2.37
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes. Nucleic Acids Res (2008) 2.27
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci U S A (2009) 1.79
AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation. Oncogene (2005) 1.60
Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol (2009) 1.58
A conserved G4 DNA binding domain in RecQ family helicases. J Mol Biol (2006) 1.54
MutSalpha binds to and promotes synapsis of transcriptionally activated immunoglobulin switch regions. Curr Biol (2005) 1.45
MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Mol Cell (2005) 1.43
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding. Arterioscler Thromb Vasc Biol (2010) 1.25
Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair. Proc Natl Acad Sci U S A (2014) 1.21
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. Nat Immunol (2005) 1.20
G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas. Cancer Res (2007) 1.18
Chromatin structure regulates gene conversion. PLoS Biol (2007) 1.12
DNA nicks promote efficient and safe targeted gene correction. PLoS One (2011) 1.09
G4 motifs correlate with promoter-proximal transcriptional pausing in human genes. Nucleic Acids Res (2011) 1.09
Selection for the G4 DNA motif at the 5' end of human genes. Mol Carcinog (2009) 1.05
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Res (2013) 1.02
Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding. Diabetes (2011) 1.01
Specific interactions of distamycin with G-quadruplex DNA. Nucleic Acids Res (2003) 1.00
A rapid and sensitive assay for DNA-protein covalent complexes in living cells. Nucleic Acids Res (2013) 0.98
MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break repair in Saccharomyces cerevisiae. PLoS One (2010) 0.98
Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts. PLoS One (2012) 0.93
E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol (2009) 0.92
Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA. PLoS One (2010) 0.92
VASP increases hepatic fatty acid oxidation by activating AMPK in mice. Diabetes (2013) 0.92
Temporal regulation of Ig gene diversification revealed by single-cell imaging. J Immunol (2009) 0.91
Targeted gene therapies: tools, applications, optimization. Crit Rev Biochem Mol Biol (2012) 0.91
Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions. Proc Natl Acad Sci U S A (2008) 0.91
DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons. J Biol Chem (2011) 0.90
Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats. J Biol Chem (2010) 0.89
Transcription-coupled mutagenesis by the DNA deaminase AID. Genome Biol (2004) 0.89
Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. Arterioscler Thromb Vasc Biol (2012) 0.87
Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control region. Nucleic Acids Res (2005) 0.87
Genetic variation stimulated by epigenetic modification. PLoS One (2008) 0.83
G4 DNA: at risk in the genome. EMBO J (2011) 0.83
High-fidelity correction of genomic uracil by human mismatch repair activities. BMC Mol Biol (2008) 0.82
Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network. PLoS One (2012) 0.78
Epigenetic modification of the repair donor regulates targeted gene correction. Mol Ther Nucleic Acids (2012) 0.77
The effects of immunosuppressants on FAS-mediated activation-induced cell death in human T lymphocytes. Transpl Int (2002) 0.76
Yin outwits Yang at the IgE locus. Nat Immunol (2003) 0.75
Molecular and genetic bases of disease. Curr Opin Genet Dev (2013) 0.75