Published in Nat Immunol on May 01, 2003
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
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ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med (2004) 2.30
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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res (2003) 2.21
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PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science (2010) 2.05
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Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J Exp Med (2005) 1.85
Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med (2008) 1.80
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
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Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78
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DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med (2004) 1.59
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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. J Exp Med (2007) 1.46
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination. EMBO J (2003) 1.46
Dependence of antibody gene diversification on uracil excision. J Exp Med (2007) 1.45
G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter. Mol Cell Biol (2009) 1.43
Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. J Exp Med (2004) 1.41
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A (2005) 1.40
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol (2010) 1.35
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex. Proc Natl Acad Sci U S A (2007) 1.34
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. J Exp Med (2003) 1.33
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med (2004) 1.29
AID from bony fish catalyzes class switch recombination. J Exp Med (2005) 1.26
The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Proc Natl Acad Sci U S A (2004) 1.24
Regulation of AID, the B-cell genome mutator. Genes Dev (2013) 1.21
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci U S A (2008) 1.20
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination. Crit Rev Immunol (2007) 1.19
Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol Cell Biol (2005) 1.18
DNA repair in antibody somatic hypermutation. Trends Immunol (2006) 1.17
Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase. J Biol Chem (2008) 1.16
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination. Mol Cell Biol (2006) 1.15
Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo. PLoS One (2008) 1.15
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med (2006) 1.14
The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription. J Exp Med (2009) 1.12
Chromatin structure regulates gene conversion. PLoS Biol (2007) 1.12
DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation. Ann N Y Acad Sci (2005) 1.11
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AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. Mol Cell Biol (2006) 1.09
Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor. J Exp Med (2004) 1.08
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med (2005) 1.06
Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell (2008) 1.05
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase. Proc Natl Acad Sci U S A (2005) 1.05
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination. Proc Natl Acad Sci U S A (2004) 1.04
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants. Proc Natl Acad Sci U S A (2008) 1.02
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.02
Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. Mol Cell Biol (2007) 1.01
AID targeting is dependent on RNA polymerase II pausing. Semin Immunol (2012) 1.01
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. PLoS Genet (2011) 1.00
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes. Immunology (2009) 0.98
The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung(-/-)msh2(-/-) mice. Immunogenetics (2005) 0.98
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med (2004) 0.98
Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci U S A (2009) 0.96
Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase. FASEB J (2008) 0.96
Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. PLoS Genet (2012) 0.94
Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias. Mol Immunol (2007) 0.93
AID and Apobec3G haphazard deamination and mutational diversity. Cell Mol Life Sci (2012) 0.93
Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res (2012) 0.92
E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol (2009) 0.92
Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol Cell Biol (2010) 0.92
Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix. Proc Natl Acad Sci U S A (2005) 0.92
Temporal regulation of Ig gene diversification revealed by single-cell imaging. J Immunol (2009) 0.91
APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication. Cell Rep (2016) 0.90
Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination. Biochim Biophys Acta (2012) 0.90
Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications. Semin Immunol (2012) 0.89
APOBEC3 proteins and genomic stability: the high cost of a good defense. Cell Cycle (2012) 0.88
Epigenetic targeting of activation-induced cytidine deaminase. Proc Natl Acad Sci U S A (2014) 0.88
Immunoglobulin class-switch recombination deficiencies. Arthritis Res Ther (2012) 0.88
A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair. J Exp Med (2007) 0.87
Engineering and optimising deaminase fusions for genome editing. Nat Commun (2016) 0.87
Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes. BMC Immunol (2005) 0.87
The histone methyltransferase MMSET regulates class switch recombination. J Immunol (2012) 0.86
AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene. Mol Immunol (2007) 0.86
Does antisense make sense of AID targeting? Proc Natl Acad Sci U S A (2008) 0.86
AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination. Front Immunol (2014) 0.85
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A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev (2016) 0.83
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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature (2009) 9.51
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Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13
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AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
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AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
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Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
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53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80
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ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
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AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
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