Published in Apoptosis on February 01, 2010
Thymoquinone inhibits murine leukemia WEHI-3 cells in vivo and in vitro. PLoS One (2014) 1.43
Potentiation of epithelial innate host responses by intercellular communication. PLoS Pathog (2010) 1.31
Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol Cancer Ther (2010) 1.16
Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PLoS One (2012) 1.04
Essential oils and their constituents as anticancer agents: a mechanistic view. Biomed Res Int (2014) 1.00
Antitumor activity of monoterpenes found in essential oils. ScientificWorldJournal (2014) 0.94
Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway. PLoS One (2014) 0.93
Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. Int J Mol Sci (2010) 0.91
Anticancer activity of essential oils and their chemical components - a review. Am J Cancer Res (2014) 0.91
Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells. PLoS One (2013) 0.90
Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS. PLoS One (2013) 0.90
Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Sci Rep (2015) 0.89
Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone. J Chem Biol (2011) 0.88
Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants. Cell Death Dis (2013) 0.88
Liquiritigenin induces tumor cell death through mitogen-activated protein kinase- (MPAKs-) mediated pathway in hepatocellular carcinoma cells. Biomed Res Int (2014) 0.86
Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats. Cell Death Dis (2013) 0.86
Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. Int J Mol Sci (2014) 0.85
Compound K induces apoptosis of bladder cancer T24 cells via reactive oxygen species-mediated p38 MAPK pathway. Cancer Biother Radiopharm (2013) 0.85
Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation. Invest New Drugs (2011) 0.84
ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells. Braz J Med Biol Res (2014) 0.82
Cardio-protective and anti-cancer therapeutic potential of Nigella sativa. Iran J Basic Med Sci (2014) 0.81
Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. BMC Cancer (2012) 0.80
Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. Mol Cancer (2014) 0.80
Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line. Int J Prev Med (2016) 0.79
Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinoma. Mol Med Rep (2016) 0.76
Apoptosis of bladder transitional cell carcinoma T24 cells induced by adenovirus-mediated inducible nitric oxide synthase gene transfection. Chin J Cancer Res (2013) 0.76
Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med (2016) 0.75
A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Int J Oncol (2016) 0.75
Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB. Oncol Lett (2016) 0.75
Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding. Am J Transl Res (2017) 0.75
Therapeutic Potential and Pharmaceutical Development of Thymoquinone: A Multitargeted Molecule of Natural Origin. Front Pharmacol (2017) 0.75
Antiproliferative and Apoptosis-Inducing Activities of Thymoquinone in Lymphoblastic Leukemia Cell Line. Indian J Hematol Blood Transfus (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron (2006) 2.55
The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology (2010) 2.52
Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Int J Biochem Cell Biol (2007) 2.20
What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today (2010) 1.74
Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter (2012) 1.70
Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Int J Cancer (2008) 1.68
Thymoquinone: a promising anti-cancer drug from natural sources. Int J Biochem Cell Biol (2005) 1.67
Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol (2004) 1.60
Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. Lab Invest (2007) 1.56
miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis. Inflamm Bowel Dis (2015) 1.47
Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST). Cancer Lett (2011) 1.41
Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia (2005) 1.38
Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell (2010) 1.36
The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Mol Cancer Ther (2012) 1.33
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. J Pharmacol Exp Ther (2004) 1.27
The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol (2002) 1.25
Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther (2007) 1.23
K-ras mutation detection in colorectal cancer using the Pyrosequencing technique. Pathol Res Pract (2007) 1.21
Targeting hypoxia for sensitization of tumors to radio- and chemotherapy. Curr Cancer Drug Targets (2013) 1.17
Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer Res (2008) 1.11
Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med (2008) 1.10
Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol (2011) 1.10
Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors. IDrugs (2007) 1.09
Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models. Scand J Gastroenterol (2007) 1.08
KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin. Hum Pathol (2003) 1.08
Aberrant methylation of DAPK in long-standing ulcerative colitis and ulcerative colitis-associated carcinoma. Pathol Res Pract (2010) 1.08
Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol (2009) 1.07
Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors. Virchows Arch (2001) 1.06
Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. Lab Invest (2005) 1.06
DAPK promotor methylation is an early event in colorectal carcinogenesis. Cancer Lett (2005) 1.04
The pan-deacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis. Cell Oncol (2010) 1.04
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J Clin Invest (2013) 1.03
Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature review. Hum Pathol (2008) 1.03
Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects. J Agric Food Chem (2005) 1.03
Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography. Angew Chem Int Ed Engl (2010) 1.03
Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course. Mod Pathol (2003) 1.02
Early involvement of death-associated protein kinase promoter hypermethylation in the carcinogenesis of Barrett's esophageal adenocarcinoma and its association with clinical progression. Neoplasia (2007) 1.01
GBP-1 acts as a tumor suppressor in colorectal cancer cells. Carcinogenesis (2012) 1.01
Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization. Oncol Rep (2007) 1.01
Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors. BMC Med Genet (2010) 1.01
Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach. Int J Oncol (2005) 1.00
APC promoter methylation and protein expression in hepatocellular carcinoma. J Cancer Res Clin Oncol (2007) 0.99
Patterns of gene amplification in gastrointestinal stromal tumors (GIST). Lab Invest (2005) 0.99
Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC. Virchows Arch (2011) 0.97
Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex. Chem Commun (Camb) (2011) 0.97
Optimal lymph node harvest in rectal cancer (UICC stages II and III) after preoperative 5-FU-based radiochemotherapy. Acetone compression is a new and highly efficient method. Am J Surg Pathol (2012) 0.96
Alterations of G1-S checkpoint in chordoma: the prognostic impact of p53 overexpression. Cancer (2005) 0.96
Overview of major classes of plant-derived anticancer drugs. Int J Biomed Sci (2009) 0.96
Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurement. J Pharm Sci (2003) 0.95
bcl-2-specific siRNAs restore gemcitabine sensitivity in human pancreatic cancer cells. J Cell Mol Med (2007) 0.95
IL-33 regulates TNF-α dependent effects in synovial fibroblasts. Int J Mol Med (2012) 0.95
Active Wnt signalling is associated with low differentiation and high proliferation in human biliary tract cancer in vitro and in vivo and is sensitive to pharmacological inhibition. Int J Oncol (2010) 0.94
Death-associated protein kinase controls STAT3 activity in intestinal epithelial cells. Am J Pathol (2013) 0.94
MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC). Lung Cancer (2004) 0.93
CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. Surgery (2011) 0.93
PIM1 kinase as a target for cancer therapy. Expert Opin Investig Drugs (2012) 0.93
Expression profile of the telomeric complex discriminates between benign and malignant pheochromocytoma. J Clin Endocrinol Metab (2003) 0.93
The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. Pancreatology (2008) 0.92
Rhenium complexes with visible-light-induced anticancer activity. ChemMedChem (2013) 0.92
Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma. BMC Cancer (2010) 0.92
P16 alterations increase the metastatic potential of endometrial carcinoma. Gynecol Oncol (2008) 0.92
Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells. Am J Pathol (2009) 0.92
Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach. Am J Pathol (2012) 0.91
Current status of therapeutic targeting of developmental signalling pathways in oncology. Curr Pharm Biotechnol (2012) 0.91
Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas. PLoS One (2011) 0.91
New drugs, old fashioned ways: ER stress induced cell death. Curr Pharm Biotechnol (2012) 0.91
Metastatic Malignant Melanoma With Complete Loss of Differentiation Markers (Undifferentiated/Dedifferentiated Melanoma): Analysis of 14 Patients Emphasizing Phenotypic Plasticity and the Value of Molecular Testing as Surrogate Diagnostic Marker. Am J Surg Pathol (2016) 0.90
Sporadic segmental Interstitial cell of cajal hyperplasia (microscopic GIST) with unusual diffuse longitudinal growth replacing the muscularis propria: differential diagnosis to hereditary GIST syndromes. Int J Clin Exp Pathol (2010) 0.90
Cellular plasticity of trans- and dedifferentiation markers in human hepatoma cells in vitro and in vivo. Int J Oncol (2009) 0.89
Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G₂ checkpoint arrest. J Cell Mol Med (2011) 0.89
Overexpression of MMP9 and tissue factor in unstable carotid plaques associated with Chlamydia pneumoniae, inflammation, and apoptosis. Ann Vasc Surg (2005) 0.89
Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines. Exp Cell Res (2012) 0.89
Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barrett's esophagus. Cancer Lett (2008) 0.89
Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Mol Med (2011) 0.89
Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer (2010) 0.88
HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Anal Bioanal Chem (2004) 0.88
The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. Int J Oncol (2007) 0.88
Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone. J Chem Biol (2011) 0.88
Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines. BMC Cancer (2012) 0.88
Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Cancer Res (2004) 0.88
Establishment and characterization of the permanent human cell line C3842 derived from a secondary chondrosarcoma in Ollier's disease. Virchows Arch (2005) 0.87
Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes. Mol Carcinog (2002) 0.87
Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. Radiat Oncol (2007) 0.87
Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21. Cancer Prev Res (Phila) (2012) 0.87
The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice. Int J Oncol (2008) 0.87