Published in Drug Discov Today on June 09, 2010
Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation. PLoS One (2015) 1.41
Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments. J Med Chem (2011) 1.06
Sesquiterpenoids lactones: benefits to plants and people. Int J Mol Sci (2013) 1.03
Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks? Philos Trans R Soc Lond B Biol Sci (2014) 0.98
Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells. BMC Cancer (2013) 0.96
NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB. J Clin Invest (2014) 0.96
Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. Int J Biol Sci (2012) 0.95
Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxid Med Cell Longev (2013) 0.92
Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int (2012) 0.91
An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation. Neurol Sci (2013) 0.90
Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement Altern Med (2015) 0.88
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization. ACS Chem Biol (2013) 0.86
Micheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge. Sci Rep (2016) 0.85
Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. Evid Based Complement Alternat Med (2013) 0.85
Advances in the research and development of natural health products as main stream cancer therapeutics. Evid Based Complement Alternat Med (2015) 0.84
Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction. PLoS One (2013) 0.83
A redox economical synthesis of bioactive 6,12-guaianolides. Org Lett (2013) 0.83
High-throughput screen of natural product libraries for hsp90 inhibitors. Biology (Basel) (2014) 0.81
Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz. Eur J Med Chem (2013) 0.80
NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Mol Cell Biol (2014) 0.80
Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis. J Anal Methods Chem (2015) 0.79
Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis. Cancer Lett (2011) 0.79
Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives. Int Immunopharmacol (2015) 0.79
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorg Med Chem (2015) 0.78
Activation of antioxidant response element in mouse primary cortical cultures with sesquiterpene lactones isolated from Tanacetum parthenium. Planta Med (2012) 0.78
Apoptosis induction by 13-acetoxyrolandrolide through the mitochondrial intrinsic pathway. Phytother Res (2013) 0.78
Sesquiterpene lactone containing extracts from two cultivars of forage chicory (Cichorium intybus) show distinctive chemical profiles and in vitro activity against Ostertagia ostertagi. Int J Parasitol Drugs Drug Resist (2015) 0.78
A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Mol Pharm (2013) 0.78
The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers. PLoS One (2013) 0.78
Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts. Int J Mol Sci (2016) 0.78
(-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen species. Toxicology (2013) 0.77
Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget (2015) 0.77
Synergistic effects of the sesquiterpene lactone, EPD, with cisplatin and paclitaxel in ovarian cancer cells. J Exp Clin Cancer Res (2015) 0.77
Parthenolide-Induced Cytotoxicity in H9c2 Cardiomyoblasts Involves Oxidative Stress. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2015) 0.76
Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells. BMC Complement Altern Med (2012) 0.76
In vitro cytotoxicity of Artemisia vulgaris L. essential oil is mediated by a mitochondria-dependent apoptosis in HL-60 leukemic cell line. BMC Complement Altern Med (2014) 0.75
Economically viable components from Jerusalem artichoke (Helianthus tuberosus L.) in a biorefinery concept. Int J Mol Sci (2015) 0.75
Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. J Med Chem (2013) 0.75
Evaluation of "Dream Herb," Calea zacatechichi, for Nephrotoxicity Using Human Kidney Proximal Tubule Cells. J Toxicol (2016) 0.75
Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs. Bioorg Med Chem (2016) 0.75
EM23, A Natural Sesquiterpene Lactone from Elephantopus mollis, Induces Apoptosis in Human Myeloid Leukemia Cells through Thioredoxin- and Reactive Oxygen Species-Mediated Signaling Pathways. Front Pharmacol (2016) 0.75
Comparative Transcriptome Analysis Identifies Putative Genes Involved in the Biosynthesis of Xanthanolides in Xanthium strumarium L. Front Plant Sci (2016) 0.75
The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission. Antimicrob Agents Chemother (2016) 0.75
Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem. BMC Complement Altern Med (2017) 0.75
Micheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response. Sci Rep (2017) 0.75
Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography. Beilstein J Org Chem (2016) 0.75
Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice. Evid Based Complement Alternat Med (2013) 0.75
Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells. Curr Genomics (2017) 0.75
Isoalantolactone Enhances the Radiosensitivity of UMSCC-10A Cells via Specific Inhibition of Erk1/2 Phosphorylation. PLoS One (2015) 0.75
Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones. Curr Med Chem (2016) 0.75
Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca. Evid Based Complement Alternat Med (2015) 0.75
Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells. Chin Med (2014) 0.75
Crystal structure of erioflorin isolated from Podanthus mitiqui (L.). Acta Crystallogr E Crystallogr Commun (2017) 0.75
Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. J Med Chem (2016) 0.75
Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method. Chem Sci (2017) 0.75
Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity. Biomedicines (2017) 0.75
Measurement of 16 polycyclic aromatic hydrocarbons in narghile waterpipe tobacco smoke. Food Chem Toxicol (2008) 2.54
Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter (2012) 1.70
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. J Pharmacol Exp Ther (2004) 1.27
Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther (2007) 1.23
Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis (2010) 1.21
Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs (2004) 1.17
Targeting hypoxia for sensitization of tumors to radio- and chemotherapy. Curr Cancer Drug Targets (2013) 1.17
Parthenolide: from plant shoots to cancer roots. Drug Discov Today (2013) 1.09
Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects. J Agric Food Chem (2005) 1.03
Phenolic compounds in particles of mainstream waterpipe smoke. Nicotine Tob Res (2012) 0.97
Overview of major classes of plant-derived anticancer drugs. Int J Biomed Sci (2009) 0.96
Dehydration studies using a novel multichamber microscale fluid bed dryer with in-line near-infrared measurement. J Pharm Sci (2003) 0.95
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. Haematologica (2007) 0.93
Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G₂ checkpoint arrest. J Cell Mol Med (2011) 0.89
HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Anal Bioanal Chem (2004) 0.88
Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone. J Chem Biol (2011) 0.88
Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes. Mol Carcinog (2002) 0.87
Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21. Cancer Prev Res (Phila) (2012) 0.87
Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. Radiat Oncol (2007) 0.87
Radiosensitization of EMT6 mammary carcinoma cells by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide. Radiother Oncol (2007) 0.87
Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Arch Biochem Biophys (2004) 0.87
The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer. Mol Carcinog (2007) 0.86
Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts. Cancer Biol Ther (2011) 0.86
Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling. Anticancer Res (2010) 0.85
Isolation and identification of oligomeric procyanidins from Crataegus leaves and flowers. Phytochemistry (2002) 0.85
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. Biochem Pharmacol (2005) 0.84
Characterization of flavonoid--biomembrane interactions. Arch Biochem Biophys (2002) 0.83
Development and validation of a near-infrared method for the quantitation of caffeine in intact single tablets. Anal Chem (2003) 0.83
Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement. AAPS PharmSciTech (2009) 0.83
Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development. Expert Opin Drug Discov (2007) 0.82
The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells. Radiat Oncol (2009) 0.82
High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. J Chromatogr A (2002) 0.82
Anti-inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis. BMC Complement Altern Med (2009) 0.82
DAPK plays an important role in panobinostat-induced autophagy and commits cells to apoptosis under autophagy deficient conditions. Apoptosis (2012) 0.82
Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo. J Agric Food Chem (2011) 0.82
Epigenetic mechanisms of plant-derived anticancer drugs. Front Biosci (Landmark Ed) (2012) 0.81
Fast identification of Echinacea purpurea dried roots using near-infrared spectroscopy. Anal Chem (2002) 0.81
Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. Phytochem Anal (2004) 0.81
Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom. Int J Food Microbiol (2004) 0.81
Formulation and stability of cytokine therapeutics. J Pharm Sci (2014) 0.81
The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway. Mol Cancer (2014) 0.80
Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. Mol Cancer (2014) 0.80
Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. Chem Biol Interact (2004) 0.80
Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes. Radiat Res (2005) 0.80
Structure-activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth. Eur J Med Chem (2009) 0.80
Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncol Rep (2008) 0.79
Simultaneous analysis of alkamides and caffeic acid derivatives for the identification of Echinacea purpurea, Echinacea angustifolia, Echinacea pallida and Parthenium integrifolium roots. Planta Med (2002) 0.79
Fractionation of polyphenols in hawthorn into polymeric procyanidins, phenolic acids and flavonoids prior to high-performance liquid chromatographic analysis. J Chromatogr A (2006) 0.78
Purified salograviolide A isolated from centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells. Int J Oncol (2008) 0.78
Synthesis, properties, and antitumor effects of a new mixed phosphine gold(I) compound in human colon cancer cells. J Inorg Biochem (2013) 0.77
Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21. Radiat Oncol (2010) 0.77
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). Eur J Pharm Biopharm (2006) 0.77
A journey under the sea: the quest for marine anti-cancer alkaloids. Molecules (2011) 0.77
Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. Mol Carcinog (2007) 0.77
Road versus roadside particle size distribution in a hot Mediterranean summer--estimation of fleet emission factors. J Air Waste Manag Assoc (2013) 0.77
Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis. Mol Carcinog (2004) 0.76
Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells. BMC Complement Altern Med (2012) 0.76
Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide. J Nat Med (2012) 0.76
Interleukin-6 and Cyclooxygenase-2 downregulation by fatty-acid fractions of Ranunculus constantinopolitanus. BMC Complement Altern Med (2009) 0.75
Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells. Molecules (2013) 0.75
Application of centrifugal force to the extraction and separation of parasorboside and gerberin from Gerbera hybrida. Phytochem Anal (2002) 0.75
Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models. Anticancer Drugs (2017) 0.75
Determination of the thickness of plastic sheets used in blister packaging by near infrared spectroscopy: development and validation of the method. Eur J Pharm Sci (2004) 0.75
Hollow-fiber membrane bioreactor for the treatment of high-strength landfill leachate. Waste Manag Res (2013) 0.75
Separation of eight selected flavan-3-ols on cellulose thin-layer chromatographic plates. J Chromatogr A (2005) 0.75
Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncol Rep (2007) 0.75
Rotation planar extraction and rotation planar chromatography of oak (Quercus robur L.) bark. J Chromatogr A (2003) 0.75