Published in Comp Med on October 01, 2009
TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity. Diabetes Metab Syndr Obes (2013) 0.79
Iron dextran increases hepatic oxidative stress and alters expression of genes related to lipid metabolism contributing to hyperlipidaemia in murine model. Biomed Res Int (2015) 0.77
Effects of the interaction of diabetes and iron supplementation on hepatic and pancreatic tissues, oxidative stress markers, and liver peroxisome proliferator-activated receptor-α expression. J Clin Biochem Nutr (2011) 0.76
Agaricus brasiliensis (sun mushroom) affects the expression of genes related to cholesterol homeostasis. Eur J Nutr (2016) 0.75
Skeletal muscle insulin resistance in hamsters with diabetes developed from obesity is involved in abnormal skeletal muscle LXR, PPAR and SREBP expression. Exp Ther Med (2016) 0.75
Altered gene expression patterns during the initiation and promotion stages of neonatally diethylstilbestrol-induced hyperplasia/dysplasia/neoplasia in the hamster uterus. Reprod Toxicol (2014) 0.75
Influence of maternal hypercholesterolemia and phytosterol intervention during gestation and lactation on dyslipidemia and hepatic lipid metabolism in offspring of Syrian golden hamsters. Mol Nutr Food Res (2016) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem (2004) 7.91
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med (1993) 6.89
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest (2006) 6.85
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell (2000) 5.92
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem (2002) 5.89
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes (2002) 5.21
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med (1990) 4.87
Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes (2005) 4.81
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest (2006) 3.21
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes (2006) 2.63
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem (2002) 2.40
SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol (2004) 2.09
Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology (2004) 1.98
Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1994) 1.71
Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2004) 1.70
A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol (2006) 1.70
FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol (2006) 1.70
Nongenetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism (1998) 1.54
Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem (2002) 1.38
Lipotoxic diseases of nonadipose tissues in obesity. Int J Obes Relat Metab Disord (2000) 1.37
Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J Biol Chem (1998) 1.35
Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int (2005) 1.31
Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes. J Biol Chem (2004) 1.08
Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. Life Sci (1995) 1.06
Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol (2007) 1.04
Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. J Biol Chem (1997) 1.00
Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia. Atherosclerosis (2002) 0.89
Effects of pine needle extract on differentiation of 3T3-L1 preadipocytes and obesity in high-fat diet fed rats. Biol Pharm Bull (2006) 0.85
METLIN: a metabolite mass spectral database. Ther Drug Monit (2005) 10.15
Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A (2002) 8.25
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol (2010) 5.79
Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A (2003) 5.21
An elliptic spatial scan statistic. Stat Med (2006) 5.09
A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking. Mol Cell Proteomics (2006) 3.62
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26
Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity (2011) 2.82
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet (2003) 2.67
An integrated mass spectrometry-based proteomic approach: quantitative analysis of tandem affinity-purified in vivo cross-linked protein complexes (QTAX) to decipher the 26 S proteasome-interacting network. Mol Cell Proteomics (2005) 2.62
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med (2005) 2.55
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry (2007) 2.43
Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron (2007) 2.38
Comparative analysis of the genomes of the temperate bacteriophages phi 11, phi 12 and phi 13 of Staphylococcus aureus 8325. Gene (2002) 2.30
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. J Proteome Res (2008) 2.27
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med (2012) 2.27
Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity. Am J Physiol Lung Cell Mol Physiol (2007) 2.21
Short telomeres and prognosis of hypertension in a chinese population. Hypertension (2009) 2.18
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16
Pentatricopeptide repeat proteins stimulate mRNA adenylation/uridylation to activate mitochondrial translation in trypanosomes. Mol Cell (2011) 2.10
Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Anal Chem (2006) 2.04
Identifying dynamic interactors of protein complexes by quantitative mass spectrometry. Mol Cell Proteomics (2007) 2.02
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol (2008) 1.90
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
An essential role for stromal interaction molecule 1 in neointima formation following arterial injury. Cardiovasc Res (2008) 1.87
Introns and splicing elements of five diverse fungi. Eukaryot Cell (2004) 1.83
Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast. Cell (2004) 1.83
Quality of reporting in systematic reviews of adverse events: systematic review. BMJ (2014) 1.81
Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum. Anal Chem (2006) 1.81
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol (2004) 1.80
Characterization of the proteasome interaction network using a QTAX-based tag-team strategy and protein interaction network analysis. Proc Natl Acad Sci U S A (2008) 1.76
Guide RNA-binding complex from mitochondria of trypanosomatids. Mol Cell (2008) 1.75
A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. J Proteome Res (2008) 1.74
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol (2010) 1.71
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71
A scan statistic for continuous data based on the normal probability model. Int J Health Geogr (2009) 1.68
An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus. J Infect Dis (2013) 1.67
miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull (2009) 1.66
A technique for retrograde intubation in mice. Lab Anim (NY) (2006) 1.65
Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions. Kidney Int (2008) 1.63
Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood (2003) 1.62
Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Mol Cell Proteomics (2010) 1.61
Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation. Exp Brain Res (2008) 1.59
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. EMBO J (2002) 1.58
C-reactive protein upregulates receptor for advanced glycation end products expression and alters antioxidant defenses in rat endothelial progenitor cells. J Cardiovasc Pharmacol (2009) 1.57
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood (2010) 1.56
The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus. PLoS Pathog (2013) 1.54
Histone acetylation and deacetylation: identification of acetylation and methylation sites of HeLa histone H4 by mass spectrometry. Mol Cell Proteomics (2002) 1.52
Oxidative stress-mediated regulation of proteasome complexes. Mol Cell Proteomics (2011) 1.50
Regulation of the 26S proteasome complex during oxidative stress. Sci Signal (2010) 1.48
Potent hepatitis B surface antigen response to treatment of hepatitis-B-e-antigen-positive chronic hepatitis B with α-interferon plus a nucleos(t)ide analog. J Gastroenterol Hepatol (2012) 1.46
Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy. Cancer Res (2009) 1.42
Value of myocardial regional perfusion on long-term function in collateral-dependent myocardium. South Med J (2008) 1.40
Deciphering networks of protein interactions at the nuclear pore complex. Mol Cell Proteomics (2002) 1.37
Tissue factor-dependent coagulation is preferentially up-regulated within arterial branching areas in a baboon model of Escherichia coli sepsis. Am J Pathol (2005) 1.37
Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ Res (2006) 1.36
RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease. J Neurosci (2007) 1.35
Inhibitory circuits and the nature of their interactions in the human motor cortex a pharmacological TMS study. J Physiol (2007) 1.34
High prevalence of multiple human herpesviruses in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. J Clin Microbiol (2006) 1.34
Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem (2009) 1.34
Phenotypic characterization of clonal and nonclonal Pseudomonas aeruginosa strains isolated from lungs of adults with cystic fibrosis. J Clin Microbiol (2007) 1.29
Detection of viral agents in fecal specimens of monkeys with diarrhea. J Med Primatol (2007) 1.29
Genetic analysis of varicella-zoster virus ORF0 to ORF4 by use of a novel luciferase bacterial artificial chromosome system. J Virol (2007) 1.29
Novel avian-origin human influenza A(H7N9) can be transmitted between ferrets via respiratory droplets. J Infect Dis (2013) 1.28
Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes. Anal Chem (2004) 1.26
Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res (2010) 1.26
In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol (2007) 1.26
Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. J Virol (2008) 1.25
GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization. Mol Biol Cell (2008) 1.23
HB tag modules for PCR-based gene tagging and tandem affinity purification in Saccharomyces cerevisiae. Yeast (2006) 1.23
MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem (2010) 1.23
A colorimetric method for point mutation detection using high-fidelity DNA ligase. Nucleic Acids Res (2005) 1.21
Census and geographic differences between respondents and nonrespondents in a case-control study of non-Hodgkin lymphoma. Am J Epidemiol (2007) 1.20
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J Proteome Res (2008) 1.20
Comparison of tests for spatial heterogeneity on data with global clustering patterns and outliers. Int J Health Geogr (2009) 1.20
The cyclic AMP receptor protein, CRP, is required for both virulence and expression of the minimal CRP regulon in Yersinia pestis biovar microtus. Infect Immun (2008) 1.20
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain (2008) 1.19
Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress. Mol Cell Biochem (2009) 1.19
miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor. Brain Res (2010) 1.18
Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent. J Bacteriol (2007) 1.18
Bayesian Variable Selection and Computation for Generalized Linear Models with Conjugate Priors. Bayesian Anal (2008) 1.17
Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Mol Endocrinol (2003) 1.17
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun (2013) 1.16
Homeostatic plasticity in human motor cortex demonstrated by two consecutive sessions of paired associative stimulation. Eur J Neurosci (2007) 1.16
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. FASEB J (2012) 1.16