Published in Sci Signal on November 03, 2009
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol (2011) 2.43
Regulating the transition from centriole to basal body. J Cell Biol (2011) 1.93
Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development. Genome Res (2011) 1.52
SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet (2013) 1.32
Coordinated genomic control of ciliogenesis and cell movement by RFX2. Elife (2014) 1.20
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
RFX2 is broadly required for ciliogenesis during vertebrate development. Dev Biol (2011) 1.06
Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Proc Natl Acad Sci U S A (2010) 1.02
RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Dev Biol (2011) 1.01
A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development (2014) 0.96
Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. Dev Biol (2011) 0.95
Morphological defects in a novel Rdh10 mutant that has reduced retinoic acid biosynthesis and signaling. Genesis (2012) 0.95
Primary cilia and Gli3 activity regulate cerebral cortical size. Dev Neurobiol (2012) 0.90
Functional specialization of sensory cilia by an RFX transcription factor isoform. Genetics (2010) 0.89
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1). J Biol Chem (2011) 0.88
Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development. PLoS One (2012) 0.83
Detection of genes regulated by Lmx1b during limb dorsalization. Dev Growth Differ (2012) 0.82
RFX7 is required for the formation of cilia in the neural tube. Mech Dev (2014) 0.81
Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis. Sci Rep (2016) 0.78
Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization. J Biol Chem (2015) 0.76
Rfx2 is required for spermatogenesis in the mouse. Genesis (2015) 0.76
Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs. FASEB J (2016) 0.76
Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans. Nucleic Acids Res (2011) 0.76
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells. Stem Cells Dev (2014) 0.75
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet (2016) 0.75
Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol (2017) 0.75
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell (2006) 3.62
Identification of intrinsic determinants of midbrain dopamine neurons. Cell (2006) 3.31
Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes. BMC Genomics (2004) 3.08
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol (2009) 2.63
Retinoic acid from the meninges regulates cortical neuron generation. Cell (2009) 2.46
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol (2011) 2.43
Hindbrain interneurons and axon guidance signaling critical for breathing. Nat Neurosci (2010) 2.34
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development (2005) 2.03
Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron (2005) 2.03
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (2005) 1.90
Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci (2007) 1.72
Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci (2003) 1.70
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol (2004) 1.64
Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development (2005) 1.61
Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes Dev (2003) 1.60
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A (2002) 1.59
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J Cell Biol (2011) 1.58
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.57
RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci (2004) 1.55
Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci (2003) 1.44
Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. Proc Natl Acad Sci U S A (2007) 1.39
FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS One (2011) 1.35
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS One (2010) 1.34
A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron (2005) 1.33
Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Sci Signal (2008) 1.33
Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem (2003) 1.32
Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J Neurosci (2011) 1.31
Rere controls retinoic acid signalling and somite bilateral symmetry. Nature (2010) 1.27
Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development (2003) 1.27
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A (2012) 1.26
A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res (2006) 1.24
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development (2003) 1.23
Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biol Chem (2004) 1.20
Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling. Dev Cell (2012) 1.20
Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem (2005) 1.18
The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci (2006) 1.15
Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development (2011) 1.12
BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev (2008) 1.12
Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr Patterns (2005) 1.12
Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell (2011) 1.12
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (2009) 1.11
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci (2010) 1.10
Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem (2007) 1.09
The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol (2008) 1.09
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development (2010) 1.07
Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J Neurosci (2005) 1.07
Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells. Cell Stem Cell (2011) 1.05
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development (2010) 1.04
Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet (2010) 1.00
Functional architecture of atrophins. J Biol Chem (2006) 1.00
A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery. Development (2006) 1.00
SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals. Proc Natl Acad Sci U S A (2013) 1.00
Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells. Brain Res Mol Brain Res (2002) 0.99
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels. J Biol Chem (2012) 0.99
Retrograde signaling onto Ret during motor nerve terminal maturation. J Neurosci (2008) 0.99
Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. J Cell Sci (2009) 0.99
Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS. Development (2011) 0.98
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc Natl Acad Sci U S A (2010) 0.98
Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins. Development (2004) 0.96
A Titin mutation defines roles for circulation in endothelial morphogenesis. Dev Biol (2004) 0.96
Morphological defects in a novel Rdh10 mutant that has reduced retinoic acid biosynthesis and signaling. Genesis (2012) 0.95
Wnt signaling is regulated by endoplasmic reticulum retention. PLoS One (2009) 0.95
Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev (2012) 0.93
Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin. Anticancer Res (2009) 0.93
Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon. J Neurosci (2010) 0.93
Involvement of CLOCK:BMAL1 heterodimer in serum-responsive mPer1 induction. Neuroreport (2003) 0.93
Control of Notch-ligand endocytosis by ligand-receptor interaction. J Cell Sci (2010) 0.92
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Dev Biol (2010) 0.90
Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development (2012) 0.89
Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol (2012) 0.89
The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development (2010) 0.88
Generation of conditional Cited2 null alleles. Genesis (2006) 0.88
Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open (2013) 0.87