Significant correlation of species longevity with DNA double strand break recognition but not with telomere length.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 2799038)

Published in Mech Ageing Dev on December 16, 2009

Authors

Antonello Lorenzini1, F Brad Johnson, Anthony Oliver, Maria Tresini, Jasmine S Smith, Mona Hdeib, Christian Sell, Vincent J Cristofalo, Thomas D Stamato

Author Affiliations

1: Drexel University College of Medicine, Department of Pathology Control, Philadelphia, PA 19102, United States.

Articles citing this

Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet (2014) 1.58

Cancer susceptibility and reproductive trade-offs: a model of the evolution of cancer defences. Philos Trans R Soc Lond B Biol Sci (2015) 1.11

Mammalian NUMT insertion is non-random. Nucleic Acids Res (2012) 0.97

Gene expression defines natural changes in mammalian lifespan. Aging Cell (2015) 0.96

53BP1 contributes to a robust genomic stability in human fibroblasts. Aging (Albany NY) (2011) 0.90

A comparative cellular and molecular biology of longevity database. Age (Dordr) (2012) 0.88

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. Sci Rep (2015) 0.79

Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans. Biogerontology (2017) 0.78

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan. Age (Dordr) (2011) 0.78

Long-term quiescent fibroblast cells transit into senescence. PLoS One (2014) 0.77

Ku circles the telomere? Aging (Albany NY) (2011) 0.77

Physical activity and telomere length in early stage breast cancer survivors. Breast Cancer Res (2014) 0.77

A nested case-controlled comparison of telomere length and psychological functioning in breast cancer survivors with and without insomnia symptoms. Rejuvenation Res (2014) 0.77

DNA damage response and DNA repair - dog as a model? BMC Cancer (2014) 0.76

Higher expression of somatic repair genes in long-lived ant queens than workers. Aging (Albany NY) (2016) 0.75

Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate. Aging (Albany NY) (2011) 0.75

Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans. Mol Endocrinol (2015) 0.75

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis. Trends Biochem Sci (2017) 0.75

Articles cited by this

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

Comparative analysis by independent contrasts (CAIC): an Apple Macintosh application for analysing comparative data. Comput Appl Biosci (1995) 16.80

Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science (2001) 8.68

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42

Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol (2003) 6.49

Cellular senescence in aging primates. Science (2006) 6.24

Delayed ageing through damage protection by the Arf/p53 pathway. Nature (2007) 3.87

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68

A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol (2004) 3.07

Phylogenetic approaches in comparative physiology. J Exp Biol (2005) 3.04

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci U S A (1995) 2.87

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J Biol Chem (1993) 2.66

EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J Biol Chem (1993) 2.34

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J Biol Chem (1994) 2.30

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mutat Res (1999) 2.08

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J (1994) 1.84

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells. Mol Cell Biol (2008) 1.76

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci U S A (1981) 1.73

Ku86 is essential in human somatic cells. Proc Natl Acad Sci U S A (2002) 1.71

Higher-level systematics of rodents and divergence time estimates based on two congruent nuclear genes. Mol Phylogenet Evol (2003) 1.66

Ku86 represses lethal telomere deletion events in human somatic cells. Proc Natl Acad Sci U S A (2009) 1.63

Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res (2003) 1.59

DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J Biol Chem (1994) 1.56

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55

Somatic mutations are frequent and increase with age in human kidney epithelial cells. Hum Mol Genet (1996) 1.50

Correlations between physiology and lifespan--two widely ignored problems with comparative studies. Aging Cell (2005) 1.42

Cellular replicative capacity correlates primarily with species body mass not longevity. Mech Ageing Dev (2005) 1.27

Yeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break. Mol Cell Biol (2003) 1.24

Asymmetric field inversion gel electrophoresis: a new method for detecting DNA double-strand breaks in mammalian cells. Radiat Res (1990) 1.21

Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines. Cancer Res (1994) 1.17

Telomere biology and cellular aging in nonhuman primate cells. Exp Cell Res (2002) 1.14

Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology. Neoplasia (2001) 1.05

Role of human Ku86 in telomere length maintenance and telomere capping. Cancer Res (2004) 1.03

Mutations to Ku reveal differences in human somatic cell lines. DNA Repair (Amst) (2008) 1.01

An asymmetric field inversion gel electrophoresis method for the separation of large DNA molecules. Anal Biochem (1989) 0.92

Transfer of Ku86 RNA antisense decreases the radioresistance of human fibroblasts. Cancer Gene Ther (2000) 0.91

More than just strand breaks: the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit. FASEB J (2005) 0.91

Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. Mol Biol Rep (1993) 0.90

Heterozygous inactivation of human Ku70/Ku86 heterodimer does not affect cell growth, double-strand break repair, or genome integrity. DNA Repair (Amst) (2005) 0.90

Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays. Mol Reprod Dev (1998) 0.89

Equine telomeres and telomerase in cellular immortalisation and ageing. Mech Ageing Dev (2003) 0.88

A cohort study of telomere and telomerase biology in cats. Am J Vet Res (2003) 0.84

DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines. Radiat Res (1993) 0.83

Rejoining of radiation-induced DNA double-strand breaks: pulsed-field electrophoresis analysis of fragment size distributions after incubation for repair. Radiat Res (2002) 0.81

DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex. Nucleic Acids Res (2002) 0.78

Two methods for assaying DNA double-strand break repair in mammalian cells by asymmetric field inversion gel electrophoresis. Radiat Res (1993) 0.77

Sensitivity of neutral filter elution but not PFGE can be modified by non-dsb chromatin damage. Int J Radiat Biol (1993) 0.77

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat Genet (2002) 4.58

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol (2004) 1.99

Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.98

Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres. Nature (2007) 1.84

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res (2002) 1.70

Replicative senescence: a critical review. Mech Ageing Dev (2004) 1.66

Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance. Structure (2012) 1.56

Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53

2000 years of parallel societies in Stone Age Central Europe. Science (2013) 1.53

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential. Nucleic Acids Res (2009) 1.44

Nuclear factor {kappa}B-mediated transactivation of telomerase prevents intimal smooth muscle cell from replicative senescence during vascular repair. Arterioscler Thromb Vasc Biol (2010) 1.44

Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. Mol Cell (2013) 1.30

Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment. J Virol (2009) 1.29

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis. Aging Cell (2007) 1.29

Cellular replicative capacity correlates primarily with species body mass not longevity. Mech Ageing Dev (2005) 1.27

Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol (2008) 1.23

Modulation of replicative senescence of diploid human cells by nuclear ERK signaling. J Biol Chem (2006) 1.15

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. Nat Struct Mol Biol (2011) 1.14

Astrocyte senescence as a component of Alzheimer's disease. PLoS One (2012) 1.11

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res (2006) 1.10

A novel telomere structure in a human alternative lengthening of telomeres cell line. Cancer Res (2005) 1.09

Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution. J Biol Chem (2010) 1.08

Functional unresponsiveness and replicative senescence of myeloid leukemia antigen-specific CD8+ T cells after allogeneic stem cell transplantation. Clin Cancer Res (2009) 1.06

Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div (2010) 1.05

Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex. J Biol Chem (2010) 1.05

Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease. Alzheimers Dement (2009) 1.05

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell Cycle (2009) 1.03

Evidence that a RecQ helicase slows senescence by resolving recombining telomeres. PLoS Biol (2007) 1.02

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. EMBO J (2009) 1.00

Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication. J Biol Chem (2008) 1.00

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts. Aging Cell (2013) 0.99

Stress-induced senescence in human and rodent astrocytes. Exp Cell Res (2010) 0.97

In vivo veritas: using yeast to probe the biological functions of G-quadruplexes. Biochimie (2008) 0.97

Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress. J Biol Chem (2002) 0.96

Regulation of collagenase expression during replicative senescence in human fibroblasts by Akt-forkhead signaling. J Biol Chem (2001) 0.96

Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination. J Biol Chem (2008) 0.95

Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol Cell Biol (2010) 0.94

Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts. Exp Cell Res (2003) 0.94

Proteasome inhibitors shorten replicative life span and induce a senescent-like phenotype of human fibroblasts. J Cell Physiol (2006) 0.93

Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry. Anal Chem (2009) 0.92

Radiation response of cells during altered protein thiol redox. Radiat Res (2003) 0.92

P62/SQSTM1 at the interface of aging, autophagy, and disease. Age (Dordr) (2014) 0.91

Compartmentalization of hnRNP-K during cell cycle progression and its interaction with calponin in the cytoplasm. J Cell Biochem (2005) 0.90

53BP1 contributes to a robust genomic stability in human fibroblasts. Aging (Albany NY) (2011) 0.90

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints. BMC Genomics (2014) 0.90

Werner syndrome protein prevents DNA breaks upon chromatin structure alteration. Aging Cell (2007) 0.90

Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts. J Cell Physiol (2003) 0.90

Ku80 facilitates chromatin binding of the telomere binding protein, TRF2. Cell Cycle (2010) 0.89

Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span. J Gerontol A Biol Sci Med Sci (2013) 0.89

The relationship of introject affiliation and personal therapy to trainee self-efficacy: a longitudinal study among psychotherapy trainees. Psychotherapy (Chic) (2012) 0.87

Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging. Stem Cells (2013) 0.86

Loss of EPC-1/PEDF expression during skin aging in vivo. J Invest Dermatol (2004) 0.86

Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication. J Cell Biochem (2008) 0.86

Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence. Exp Gerontol (2002) 0.86

Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells. Cancer Res (2005) 0.86

Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential. Methods (2012) 0.85

INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling. Cancer Cell Int (2009) 0.84

Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence. Genes Dev (2013) 0.84

Long-term IGF-I exposure decreases autophagy and cell viability. PLoS One (2010) 0.84

Impact of age on markers of HIV-1 disease. Future Virol (2013) 0.82

Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes. Mol Biol Cell (2005) 0.82

Telomeres do the (un)twist: helicase actions at chromosome termini. Biochim Biophys Acta (2009) 0.82

The disposable soma theory revisited: time as a resource in the theories of aging. Cell Cycle (2011) 0.82

Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice. Exp Gerontol (2010) 0.81

The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res (2004) 0.81

Isolation of G-quadruplex DNA using NMM-sepharose affinity chromatography. Methods Mol Biol (2010) 0.81

Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential. Methods Mol Biol (2010) 0.81

Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors. Mech Ageing Dev (2002) 0.81

Ectopic expression of DICE1 suppresses tumor cell growth. Oncol Rep (2004) 0.81

The senescence arrest program and the cell cycle. Methods Mol Biol (2014) 0.80

Exploring human/animal intersections: converging lines of evidence in comparative models of aging. Alzheimers Dement (2007) 0.79

Immortalization in a normal foreskin fibroblast culture following transduction of cyclin A2 or cdk1 genes in retroviral vectors. Exp Cell Res (2004) 0.79

Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain. Mech Ageing Dev (2009) 0.79

Insulin-like growth factor-I produced by seminal vesicles: relationship to intraepithelial basal cell hyperplasia in the prostate. Clin Cancer Res (2007) 0.79

DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex. Nucleic Acids Res (2002) 0.78

Bin1 interacts with and restrains the DNA end-binding protein complex Ku. Cell Cycle (2007) 0.78

Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication. J Biol Chem (2013) 0.78

Detecting senescence: methods and approaches. Methods Mol Biol (2014) 0.78

Ku circles the telomere? Aging (Albany NY) (2011) 0.77

A nested case-controlled comparison of telomere length and psychological functioning in breast cancer survivors with and without insomnia symptoms. Rejuvenation Res (2014) 0.77

Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells. Exp Cell Res (2003) 0.77

Plexin D1: new potential biomarker for cervical cancer. J Immunoassay Immunochem (2012) 0.77

Meeting report: second international meeting on quadruplex DNA. Biochimie (2009) 0.76

Protein degradation via the proteosome. Methods Mol Biol (2004) 0.76

Analysis of nonlinear gene expression progression reveals extensive pathway and age-specific transitions in aging human brains. PLoS One (2013) 0.75

Telomere stability and carcinogenesis: an off-again, on-again relationship. J Clin Invest (2012) 0.75

Introductory review of computational cell cycle modeling. Methods Mol Biol (2014) 0.75

Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate. Aging (Albany NY) (2011) 0.75

G-ruption: the third international meeting on G-quadruplex and G-assembly. Biochimie (2012) 0.75