Published in J Biol Chem on January 11, 2002
Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. J Biol Chem (2006) 1.07
Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene (2012) 1.05
Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in Arabidopsis. Plant Physiol (2007) 1.01
Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase. Eukaryot Cell (2010) 0.88
Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro. Toxicol In Vitro (2012) 0.84
Cancer drug resistance: redox resetting renders a way. Oncotarget (2016) 0.84
Molecular analysis of Ku redox regulation. BMC Mol Biol (2009) 0.84
Glucose deprivation increases nuclear DNA repair protein Ku and resistance to radiation induced oxidative stress in human cancer cells. Cell Biochem Funct (2009) 0.81
Radiosensitive gene therapy through imRNA expression for silencing manganese superoxide dismutase. J Cancer Res Clin Oncol (2009) 0.81
Oxidative Stress-Induced Protein Damage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Efficacy. Mol Cancer Res (2016) 0.81
A bioactive probe for glutathione-dependent antioxidant capacity in breast cancer patients: implications in measuring biological effects of arsenic compounds. J Pharmacol Toxicol Methods (2013) 0.79
A bioactive probe of the oxidative pentose phosphate cycle: novel strategy to reverse radioresistance in glucose deprived human colon cancer cells. Toxicol In Vitro (2012) 0.79
Protein oxidation, UVA and human DNA repair. DNA Repair (Amst) (2016) 0.75
Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer. Oncotarget (2016) 0.75
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat Genet (2002) 4.58
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98
Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res (2004) 2.73
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
Prognostic significance of tumor oxygenation in humans. Cancer Lett (2003) 1.88
Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres. Nature (2007) 1.84
An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res (2002) 1.70
Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding. Cancer Res (2004) 1.59
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome. Int J Radiat Oncol Biol Phys (2007) 1.55
Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy. Cancer Res (2006) 1.50
Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PLoS One (2009) 1.37
Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Res (2009) 1.35
Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res (2005) 1.25
Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia. J Biol Chem (2007) 1.21
Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents. Appl Radiat Isot (2009) 1.21
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene (2004) 1.18
Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding. J Invest Dermatol (2006) 1.17
Significant correlation of species longevity with DNA double strand break recognition but not with telomere length. Mech Ageing Dev (2009) 1.10
Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. Mol Cancer Ther (2005) 1.05
Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients. Clin Cancer Res (2004) 1.03
p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab (2005) 1.01
EF5 binding and clinical outcome in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys (2006) 1.01
VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Am J Physiol Regul Integr Comp Physiol (2002) 0.99
Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygen. Cancer Res (2002) 0.98
The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study. Transl Oncol (2010) 0.98
Selenomethionine protects against adverse biological effects induced by space radiation. Free Radic Biol Med (2004) 0.97
Early detection of radiation therapy response in non-Hodgkin's lymphoma xenografts by in vivo 1H magnetic resonance spectroscopy and imaging. NMR Biomed (2010) 0.95
Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation. Int J Radiat Oncol Biol Phys (2008) 0.95
Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cells. Cancer Lett (2004) 0.95
Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors. Radiat Res (2008) 0.94
Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation. Cancer Res (2003) 0.94
Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus. Pediatr Res (2002) 0.94
A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status. Int J Radiat Biol (2008) 0.93
Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species. Chem Commun (Camb) (2002) 0.93
Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats. Radiat Res (2004) 0.92
In situ oxygen utilization in the rat intervertebral disc. J Anat (2007) 0.92
Radiation response of cells during altered protein thiol redox. Radiat Res (2003) 0.92
Liver X receptor is a therapeutic target for photoaging and chronological skin aging. Mol Endocrinol (2008) 0.90
Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F-EF5 and positron emission tomography. BJU Int (2007) 0.86
Radiation dosimetry and biodistribution of the hypoxia tracer (18)F-EF5 in oncologic patients. Cancer Biother Radiopharm (2012) 0.86
Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication. J Cell Biochem (2008) 0.86
Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sections. Adv Exp Med Biol (2003) 0.84
Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution. Int J Radiat Biol (2008) 0.84
Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo. Radiat Oncol (2010) 0.83
Role of vicinal protein thiols in radiation and cytotoxic responses. Radiat Res (2006) 0.83
DNA strand breakage by bivalent metal ions and ionizing radiation. Int J Radiat Biol (2007) 0.83
Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosis. J Biomed Opt (2007) 0.83
Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature. Head Neck (2005) 0.81
Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival. Prostate (2005) 0.81
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Res (2004) 0.80
Tumor hypoxia as a modifier of DNA strand break and cross-link repair. Curr Mol Med (2009) 0.79
Bin1 interacts with and restrains the DNA end-binding protein complex Ku. Cell Cycle (2007) 0.78
DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex. Nucleic Acids Res (2002) 0.78
Single-cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry. Int J Cancer (2014) 0.78
Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine. Radiat Res (2003) 0.77
In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors. Radiother Oncol (2003) 0.77
Hypoxia in the androgen-dependent Shionogi model for prostate cancer at three stages. Radiat Res (2004) 0.76
pO(2)-dependent NO production determines OPPC activity in macrophages. Free Radic Biol Med (2009) 0.76
In regard to Brown et al. (Int J Radiat Oncol Biol Phys 2010;78:323-327). Int J Radiat Oncol Biol Phys (2011) 0.75
In regard to Vordermark et al. (Int J Radiat Oncol Biol Phys 2004;58:1242-1250). Int J Radiat Oncol Biol Phys (2004) 0.75
Re: Devic et al. (Int J Radiat Oncol Biol Phys 2010;78:1555-1562). Int J Radiat Oncol Biol Phys (2011) 0.75
Androgen withdrawal fails to induce detectable tissue hypoxia in the rat prostate. Prostate (2014) 0.75
Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. Adv Exp Med Biol (2003) 0.75
Sequentially-induced responses define tumour cell radiosensitivity. Int J Radiat Biol (2011) 0.75