Published in Science on February 02, 2006
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Lamin A-dependent nuclear defects in human aging. Science (2006) 6.71
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Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A (2012) 2.74
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A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med (2009) 2.65
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A (2006) 2.64
Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc Natl Acad Sci U S A (2010) 2.41
DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39
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Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell (2007) 2.07
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Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene (2007) 1.92
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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell (2015) 1.88
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science (2015) 1.83
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol Cell Biol (2008) 1.82
Telomere dynamics rather than age predict life expectancy in the wild. Proc Biol Sci (2009) 1.76
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun (2014) 1.72
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol (2007) 1.70
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65
Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS One (2011) 1.62
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res (2007) 1.60
Effects of age and heart failure on human cardiac stem cell function. Am J Pathol (2011) 1.57
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc Natl Acad Sci U S A (2011) 1.56
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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1.50
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell (2010) 1.43
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal (2009) 1.43
MicroRegulators come of age in senescence. Trends Genet (2011) 1.42
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41
Diphosphoinositol polyphosphates: metabolic messengers? Mol Pharmacol (2009) 1.41
A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev (2007) 1.39
Targeting cellular senescence prevents age-related bone loss in mice. Nat Med (2017) 1.39
Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res (2009) 1.38
SASPense and DDRama in cancer and ageing. Nat Cell Biol (2009) 1.38
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
Senescent cells harbour features of the cancer epigenome. Nat Cell Biol (2013) 1.34
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia (2010) 1.33
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Impact of genomic damage and ageing on stem cell function. Nat Cell Biol (2014) 1.33
Chromatin structure as a mediator of aging. FEBS Lett (2010) 1.33
Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis. Aging Cell (2007) 1.29
UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell (2008) 1.26
Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol (2013) 1.25
Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol (2008) 1.23
Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol (2008) 1.23
The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell (2012) 1.23
A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS One (2009) 1.21
Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta (2007) 1.21
Senescent cells communicate via intercellular protein transfer. Genes Dev (2015) 1.21
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet (2012) 1.20
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A (2012) 1.20
Ionizing radiation and aging: rejuvenating an old idea. Aging (Albany NY) (2009) 1.18
Assessing cell and organ senescence biomarkers. Circ Res (2012) 1.17
Senescence and the pro-tumorigenic stroma. Crit Rev Oncog (2013) 1.16
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Cell divisions are required for L1 retrotransposition. Mol Cell Biol (2006) 1.13
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Astrocyte senescence as a component of Alzheimer's disease. PLoS One (2012) 1.11
Significant correlation of species longevity with DNA double strand break recognition but not with telomere length. Mech Ageing Dev (2009) 1.10
Peroxisomes and aging. Biochim Biophys Acta (2006) 1.09
Contributions of DNA interstrand cross-links to aging of cells and organisms. Nucleic Acids Res (2007) 1.09
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany NY) (2013) 1.09
Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst) (2007) 1.08
Tumor suppressor mechanisms in immune aging. Curr Opin Immunol (2009) 1.08
BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem (2009) 1.07
The ageing epigenome: damaged beyond repair? Ageing Res Rev (2009) 1.05
Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease. Alzheimers Dement (2009) 1.05
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem (2003) 2.69
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol (2002) 2.27
Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12
The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle (2008) 2.09
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A (2006) 2.06
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Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell (2004) 1.87
Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 1.86
Proteomic profiling of Myc-associated proteins. Cell Cycle (2010) 1.80
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell (2013) 1.62
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem (2004) 1.61
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41
Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point. Mol Biol Cell (2003) 1.34
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol (2003) 1.32
Involvement of the INK4a/Arf gene locus in senescence. Aging Cell (2003) 1.28
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. J Cell Sci (2002) 1.26
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY) (2013) 1.26
Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev (2005) 1.25
The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell (2012) 1.23
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res (2003) 1.18
Analysis of cell cycle phases and progression in cultured mammalian cells. Methods (2007) 1.12
Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts. EMBO Rep (2003) 1.10
A proposal to sequence genomes of unique interest for research on aging. J Gerontol A Biol Sci Med Sci (2007) 1.10
The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression. J Biol Chem (2002) 1.06
Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I. J Biol Chem (2003) 1.06
Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal (2007) 1.04
Epigenetic control of aging. Antioxid Redox Signal (2010) 1.02
Transcriptional landscape of repetitive elements in normal and cancer human cells. BMC Genomics (2014) 1.01
Reconstructing networks of pathways via significance analysis of their intersections. BMC Bioinformatics (2008) 1.01
Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay. Aging (Albany NY) (2011) 0.99
NFAT4 is required for JC virus infection of glial cells. J Virol (2006) 0.99
A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells. J Cell Mol Med (2010) 0.99
A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging. Age (Dordr) (2014) 0.98
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit. Brain Res Bull (2006) 0.97
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res (2009) 0.96
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes (2012) 0.95
The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. Cell Signal (2008) 0.89
c-Myc localization within the nucleus: evidence for association with the PML nuclear body. J Cell Biochem (2004) 0.89
Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Lett (2004) 0.88
Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell (2003) 0.88
Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. J Androl (2007) 0.88
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome (2009) 0.86
Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis. Oncogene (2003) 0.86
How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a. Aging (Albany NY) (2013) 0.86
Cellular senescence, epigenetic switches and c-Myc. Cell Cycle (2006) 0.86
Surprise ending. Nat Genet (2003) 0.84
Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion. BMC Physiol (2012) 0.83
The effects of aging on the expression of Wnt pathway genes in mouse tissues. Age (Dordr) (2014) 0.81
Probing the depths of cellular senescence. J Cell Biol (2013) 0.81
Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle (2011) 0.80
Regulation of RKIP function by Helicobacter pylori in gastric cancer. PLoS One (2012) 0.80
Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Virology (2007) 0.79
Gene targeting comes to top-down drug screens. Trends Biotechnol (2002) 0.77
Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation. BMC Bioinformatics (2007) 0.77
Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Transgenic Res (2009) 0.76
Reproductive cloning conserves cellular senescence. Nat Cell Biol (2003) 0.75