Published in Blood on November 06, 2009
Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol (2012) 1.48
Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev (2010) 1.40
The ABCs of membrane transporters in health and disease (SLC series): introduction. Mol Aspects Med (2013) 1.32
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin. J Biol Chem (2013) 1.27
Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism. Nat Genet (2012) 1.26
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. J Neural Transm (Vienna) (2010) 1.25
Multidrug Resistance Proteins (MRPs) and Cancer Therapy. AAPS J (2015) 1.15
Genetic disorders of vitamin B₁₂ metabolism: eight complementation groups--eight genes. Expert Rev Mol Med (2010) 1.08
Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns. Orphanet J Rare Dis (2012) 0.98
Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells. Free Radic Biol Med (2011) 0.97
Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner. Mol Biol Cell (2012) 0.93
Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells. Autophagy (2012) 0.89
Investigation of the ABC transporter MRP1 in selected patients with presumed defects in vitamin B12 absorption. Blood (2011) 0.84
An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogs. Mol Genet Metab (2013) 0.82
Maximal load of the vitamin B12 transport system: a study on mice treated for four weeks with high-dose vitamin B12 or cobinamide. PLoS One (2012) 0.82
Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor. Biochimie (2013) 0.80
Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res (2015) 0.77
Ins and outs of cellular cobalamin transport. Blood (2010) 0.76
Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1. Sci Rep (2016) 0.76
Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system. Int J Nanomedicine (2015) 0.76
Absorption and blood/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations. Biochimie (2015) 0.76
Lack of megalin expression in adult human terminal ileum suggests megalin-independent cubilin/amnionless activity during vitamin B12 absorption. Physiol Rep (2014) 0.76
Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrients (2016) 0.76
ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease. Biomed Res Int (2016) 0.75
Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1. ISRN Toxicol (2013) 0.75
Concept mapping One-Carbon Metabolism to model future ontologies for nutrient-gene-phenotype interactions. Genes Nutr (2014) 0.75
Cell Type-Specific Modulation of Cobalamin Uptake by Bovine Serum. PLoS One (2016) 0.75
Hepatocyte SLAMF3 reduced specifically the multidrugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs. Oncotarget (2016) 0.75
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A (2008) 4.61
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov (2012) 2.74
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A (2007) 2.39
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res (2007) 2.19
Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. Crit Care Med (2006) 2.06
Identification of the receptor scavenging hemopexin-heme complexes. Blood (2005) 1.97
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett (2005) 1.96
The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood (2003) 1.91
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2003) 1.90
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol (2003) 1.73
[Diagnosis of vitamin B12 deficiency--time for reflection]. Ugeskr Laeger (2003) 1.72
CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal (2012) 1.64
Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem (2003) 1.63
Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch (2006) 1.58
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J (2003) 1.57
Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS. Gut (2011) 1.52
Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol (2012) 1.48
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell (2012) 1.46
Effect of vitamin B12 treatment on haptocorrin. Clin Chem (2006) 1.46
The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor. Blood (2007) 1.41
CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int J Biochem Cell Biol (2002) 1.38
Does the absence of ABCC6 (multidrug resistance protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery? Cell Cycle (2008) 1.37
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res (2004) 1.35
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci U S A (2013) 1.31
J-binding protein increases the level and retention of the unusual base J in trypanosome DNA. Mol Microbiol (2002) 1.30
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol (2005) 1.29
Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology (2005) 1.28
Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation. Blood (2006) 1.27
Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo. Blood (2005) 1.25
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol (2002) 1.21
The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei. Mol Biochem Parasitol (2002) 1.20
Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. J Biol Chem (2004) 1.20
Tissue distribution and induction of human multidrug resistant protein 3. Lab Invest (2002) 1.19
Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res (2009) 1.18
Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex. J Am Soc Nephrol (2005) 1.15
Recognition of base J in duplex DNA by J-binding protein. J Biol Chem (2001) 1.15
Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome. J Am Soc Nephrol (2002) 1.14
Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci U S A (2005) 1.14
Serum soluble CD163 predicts risk of type 2 diabetes in the general population. Clin Chem (2010) 1.12
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania. Nucleic Acids Res (2005) 1.11
Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone. Mol Ther (2012) 1.10
Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clin Cancer Res (2006) 1.09
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate. Clin Cancer Res (2008) 1.07
Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J. Mol Biochem Parasitol (2008) 1.07
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem (2003) 1.07
No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study. J Affect Disord (2004) 1.06
Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. Arthritis Rheum (2004) 1.06
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Cancer Res (2010) 1.06
Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. Biochem J (2003) 1.04
Secondary loss of chloroplasts in trypanosomes. Proc Natl Acad Sci U S A (2003) 1.03
Soluble haemoglobin scavenger receptor (sCD163) in patients with suspected community-acquired infections. APMIS (2006) 1.02
Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. J Immunol (2009) 1.02
A minor fraction of base J in kinetoplastid nuclear DNA is bound by the J-binding protein 1. Mol Biochem Parasitol (2005) 1.02
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther (2008) 1.02
Holotranscobalamin as an indicator of dietary vitamin B12 deficiency. Clin Chem (2003) 1.01
cGMP transport by vesicles from human and mouse erythrocytes. FEBS J (2007) 1.01
Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis. Nucleic Acids Res (2002) 1.01
Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo. Clin Cancer Res (2009) 1.01
Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins. Biochemistry (2007) 1.00
A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women. Am J Clin Nutr (2006) 1.00
Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Mol Endocrinol (2005) 0.98
Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor. Biochemistry (2005) 0.98
Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes. Nature (2010) 0.97
Serum trefoil factors in patients with inflammatory bowel disease. Digestion (2006) 0.97
P-glycoprotein ABCB1: a major player in drug handling by mammals. J Clin Invest (2013) 0.97
Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Mol Pharmacol (2008) 0.97
Determination of vitamin B6 vitamers and pyridoxic acid in plasma: development and evaluation of a high-performance liquid chromatographic assay. Anal Biochem (2002) 0.96
Proteomic analysis of aqueous humour from patients with acute corneal rejection. Acta Ophthalmol Scand (2005) 0.96
Factors affecting the level and localization of the transferrin receptor in Trypanosoma brucei. J Biol Chem (2004) 0.96
The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging. Oxid Med Cell Longev (2013) 0.95
Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family. J Neurochem (2007) 0.95
Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Cancer Res (2012) 0.95
Assembly of the intrinsic factor domains and oligomerization of the protein in the presence of cobalamin. Biochemistry (2004) 0.95
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. J Biol Chem (2002) 0.94
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1. Nucleic Acids Res (2011) 0.93
Vitamin B6 level is associated with symptoms of depression. Psychother Psychosom (2004) 0.93
Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides. Mol Pharmacol (2007) 0.93
Expression of the epidermal growth factor system in endometrioid endometrial cancer. Gynecol Oncol (2006) 0.93
Promoter hypomethylation and upregulation of trefoil factors in prostate cancer. Int J Cancer (2010) 0.92
The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants. J Leukoc Biol (2006) 0.92
Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo. Mol Cancer Ther (2009) 0.92
Diversity in rat tissue accumulation of vitamin B12 supports a distinct role for the kidney in vitamin B12 homeostasis. Nephrol Dial Transplant (2003) 0.91
Telomeric localization of the modified DNA base J in the genome of the protozoan parasite Leishmania. Nucleic Acids Res (2007) 0.91
Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo. Gastroenterology (2009) 0.90
Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes (2013) 0.90
Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD. Am J Kidney Dis (2006) 0.90
Development and evaluation of an ELISA for human trefoil factor 3. Clin Chem (2002) 0.90
Holo-transcobalamin concentration and transcobalamin saturation reflect recent vitamin B12 absorption better than does serum vitamin B12. Clin Chem (2004) 0.89
Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12). Am J Physiol Renal Physiol (2002) 0.89