Published in Proc Natl Acad Sci U S A on January 27, 2003
Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis. Plant Cell (2004) 7.11
Evolution of energy metabolism and its compartmentation in Kinetoplastida. Kinetoplastid Biol Dis (2003) 1.33
Possible loss of the chloroplast genome in the parasitic flowering plant Rafflesia lagascae (Rafflesiaceae). Mol Biol Evol (2014) 1.16
Comparative analysis of the complete plastid genome sequence of the red alga Gracilaria tenuistipitata var. liui provides insights into the evolution of rhodoplasts and their relationship to other plastids. J Mol Evol (2004) 1.13
Repetitive elements in genomes of parasitic protozoa. Microbiol Mol Biol Rev (2003) 1.09
Genomics and chloroplast evolution: what did cyanobacteria do for plants? Genome Biol (2003) 1.06
Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. Biochem J (2012) 0.88
Emerging roles of PPR proteins in trypanosomes: switches, blocks, and triggers. RNA Biol (2013) 0.83
Niche metabolism in parasitic protozoa. Philos Trans R Soc Lond B Biol Sci (2006) 0.82
Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. Biomed Res Int (2015) 0.78
Homologues of Arabidopsis Microtubule-Associated AIR9 in Trypanosomatid Parasites: Hints on Evolution and Function. Plant Signal Behav (2007) 0.77
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Nature (1999) 8.04
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (1999) 7.54
You are what you eat: a gene transfer ratchet could account for bacterial genes in eukaryotic nuclear genomes. Trends Genet (1998) 6.64
Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus. Proc Natl Acad Sci U S A (2002) 5.48
The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J (1999) 4.05
Plastid in human parasites. Nature (1996) 3.25
A mitochondrial remnant in the microsporidian Trachipleistophora hominis. Nature (2002) 2.98
Microsporidia: biology and evolution of highly reduced intracellular parasites. Annu Rev Microbiol (2002) 2.56
Membrane heredity and early chloroplast evolution. Trends Plant Sci (2000) 2.51
Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett (1977) 2.44
Mitochondrial DNA repairs double-strand breaks in yeast chromosomes. Nature (1999) 2.05
The function of genomes in bioenergetic organelles. Philos Trans R Soc Lond B Biol Sci (2003) 1.83
The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica. Mol Microbiol (1999) 1.75
Plant-like traits associated with metabolism of Trypanosoma parasites. Proc Natl Acad Sci U S A (2003) 1.59
Specific treatment of Chagas disease: current status and new developments. Curr Opin Infect Dis (2001) 1.51
Mitochondria as we don't know them. Trends Biochem Sci (2002) 1.49
Complex mtDNA constitutes an approximate 620-kb insertion on Arabidopsis thaliana chromosome 2: implication of potential sequencing errors caused by large-unit repeats. Proc Natl Acad Sci U S A (2001) 1.47
Mitochondrial type iron-sulfur cluster assembly in the amitochondriate eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS. Mol Biol Evol (2001) 1.45
Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolytica. Mol Cell Biol (1999) 1.39
Genome sequencing of a 239-kb region of rice chromosome 10L reveals a high frequency of gene duplication and a large chloroplast DNA insertion. Mol Genet Genomics (2002) 1.28
The evolutionary origin of the 35 kb circular DNA of Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry. Mol Gen Genet (1994) 1.23
How do mitochondrial genes get into the nucleus? Trends Genet (2001) 1.23
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.20
Metabolic aspects of glycosomes in trypanosomatidae - new data and views. Parasitol Today (2000) 1.18
Purification and cloning of chloroplast 6-phosphogluconate dehydrogenase from spinach. Cyanobacterial genes for chloroplast and cytosolic isoenzymes encoded in eukaryotic chromosomes. Eur J Biochem (2001) 1.14
A cyanobacterial gene in nonphotosynthetic protists--an early chloroplast acquisition in eukaryotes? Curr Biol (2002) 1.13
Parasitology. Drugs to combat tropical protozoan parasites. Science (2002) 1.08
Base J originally found in kinetoplastida is also a minor constituent of nuclear DNA of Euglena gracilis. Nucleic Acids Res (2000) 1.05
One, two, three: nature's tool box for building plastids. Protoplasma (2002) 1.04
Chaperonin 60 phylogeny provides further evidence for secondary loss of mitochondria among putative early-branching eukaryotes. Mol Biol Evol (2001) 1.01
DNA circles with cruciforms from Isospora (Toxoplasma) gondii. Biochim Biophys Acta (1984) 0.97
Lateral gene transfers and the evolution of eukaryotes: theories and data. Int J Syst Evol Microbiol (2002) 0.96
tef1, a Phytophthora infestans gene encoding translation elongation factor 1alpha. Gene (2000) 0.84
The genomics of symbiosis: hosts keep the baby and the bath water. Proc Natl Acad Sci U S A (2002) 0.78
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A (2008) 4.61
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov (2012) 2.74
Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. Blood (2009) 2.49
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A (2007) 2.39
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res (2007) 2.19
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2003) 1.90
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol (2003) 1.73
Gene transfer from organelles to the nucleus: frequent and in big chunks. Proc Natl Acad Sci U S A (2003) 1.68
Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem (2003) 1.63
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J (2003) 1.57
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell (2012) 1.46
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res (2004) 1.35
J-binding protein increases the level and retention of the unusual base J in trypanosome DNA. Mol Microbiol (2002) 1.30
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol (2005) 1.29
Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology (2005) 1.28
The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei. Mol Biochem Parasitol (2002) 1.20
Tissue distribution and induction of human multidrug resistant protein 3. Lab Invest (2002) 1.19
Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res (2009) 1.18
Recognition of base J in duplex DNA by J-binding protein. J Biol Chem (2001) 1.15
Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci U S A (2005) 1.14
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania. Nucleic Acids Res (2005) 1.11
Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J. Mol Biochem Parasitol (2008) 1.07
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem (2003) 1.07
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Cancer Res (2010) 1.06
Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. Biochem J (2003) 1.04
A minor fraction of base J in kinetoplastid nuclear DNA is bound by the J-binding protein 1. Mol Biochem Parasitol (2005) 1.02
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther (2008) 1.02
Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis. Nucleic Acids Res (2002) 1.01
cGMP transport by vesicles from human and mouse erythrocytes. FEBS J (2007) 1.01
Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Mol Pharmacol (2008) 0.97
P-glycoprotein ABCB1: a major player in drug handling by mammals. J Clin Invest (2013) 0.97
Factors affecting the level and localization of the transferrin receptor in Trypanosoma brucei. J Biol Chem (2004) 0.96
Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Cancer Res (2012) 0.95
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. J Biol Chem (2002) 0.94
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1. Nucleic Acids Res (2011) 0.93
Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides. Mol Pharmacol (2007) 0.93
Telomeric localization of the modified DNA base J in the genome of the protozoan parasite Leishmania. Nucleic Acids Res (2007) 0.91
Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo. Gastroenterology (2009) 0.90
Drug resistance in the mouse cancer clinic. Drug Resist Updat (2012) 0.89
The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res (2005) 0.89
ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun (2011) 0.88
Trypanosomes change their transferrin receptor expression to allow effective uptake of host transferrin. Mol Microbiol (2005) 0.88
The physiological significance of transferrin receptor variations in Trypanosoma brucei. Mol Biochem Parasitol (2002) 0.87
Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo. Cell Cycle (2010) 0.87
Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays. FASEB J (2011) 0.87
The expression level determines the surface distribution of the transferrin receptor in Trypanosoma brucei. Mol Microbiol (2003) 0.85
Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sites. Mol Biochem Parasitol (2002) 0.85
Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA. Evidence for both major and minor groove contacts. J Biol Chem (2002) 0.84
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm. Biochem J (2007) 0.84
EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors. PLoS One (2012) 0.82
Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding. J Am Chem Soc (2012) 0.82
Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases. DNA Repair (Amst) (2004) 0.81
Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei. Mol Biochem Parasitol (2003) 0.81
Parasitology: switching like for like. Nature (2006) 0.79
Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs. Mol Pharmacol (2002) 0.78
Analysis of telomere length variation in Leishmania over time. Mol Biochem Parasitol (2006) 0.77
Mega-dose vitamin C as therapy for human cancer? Proc Natl Acad Sci U S A (2008) 0.75
Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol. Cancer Prev Res (Phila) (2012) 0.75