Published in J Biol Chem on November 07, 2001
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res (2007) 2.19
JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes. Nucleic Acids Res (2009) 2.10
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell (2012) 1.46
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res (2011) 1.32
The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes. Chromosome Res (2005) 1.21
Trypanosome telomeres are protected by a homologue of mammalian TRF2. Mol Cell Biol (2005) 1.19
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania. Nucleic Acids Res (2005) 1.11
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads. Nat Protoc (2012) 1.09
Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei. Nucleic Acids Res (2010) 1.08
JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Mol Biochem Parasitol (2007) 0.99
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1. Nucleic Acids Res (2011) 0.93
JBP1 and JBP2 proteins are Fe2+/2-oxoglutarate-dependent dioxygenases regulating hydroxylation of thymidine residues in trypanosome DNA. J Biol Chem (2012) 0.93
Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genome. J Biol Chem (2014) 0.93
Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing. Nucleic Acids Res (2015) 0.81
Glycotargeting to improve cellular delivery efficiency of nucleic acids. Glycoconj J (2007) 0.79
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A (2008) 4.61
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov (2012) 2.74
Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. Blood (2009) 2.49
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A (2007) 2.39
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res (2007) 2.19
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2003) 1.90
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol (2003) 1.73
Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem (2003) 1.63
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J (2003) 1.57
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell (2012) 1.46
Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides. Org Lett (2003) 1.42
Biochemical and genetic studies of the VPg uridylylation reaction catalyzed by the RNA polymerase of poliovirus. J Virol (2003) 1.37
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res (2004) 1.35
J-binding protein increases the level and retention of the unusual base J in trypanosome DNA. Mol Microbiol (2002) 1.30
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol (2005) 1.29
Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology (2005) 1.28
The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei. Mol Biochem Parasitol (2002) 1.20
Tissue distribution and induction of human multidrug resistant protein 3. Lab Invest (2002) 1.19
Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res (2009) 1.18
A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy. J Am Chem Soc (2005) 1.17
Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase. J Biol Chem (2003) 1.16
Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci U S A (2005) 1.14
The conformation of neurotensin bound to its G protein-coupled receptor. Proc Natl Acad Sci U S A (2003) 1.14
Thioglycuronides: synthesis and application in the assembly of acidic oligosaccharides. Org Lett (2004) 1.11
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania. Nucleic Acids Res (2005) 1.11
Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J. Mol Biochem Parasitol (2008) 1.07
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem (2003) 1.07
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Cancer Res (2010) 1.06
Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. Biochem J (2003) 1.04
Secondary loss of chloroplasts in trypanosomes. Proc Natl Acad Sci U S A (2003) 1.03
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther (2008) 1.02
A minor fraction of base J in kinetoplastid nuclear DNA is bound by the J-binding protein 1. Mol Biochem Parasitol (2005) 1.02
Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis. Nucleic Acids Res (2002) 1.01
cGMP transport by vesicles from human and mouse erythrocytes. FEBS J (2007) 1.01
Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. Angew Chem Int Ed Engl (2013) 1.01
P-glycoprotein ABCB1: a major player in drug handling by mammals. J Clin Invest (2013) 0.97
Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Mol Pharmacol (2008) 0.97
Factors affecting the level and localization of the transferrin receptor in Trypanosoma brucei. J Biol Chem (2004) 0.96
Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit. J Biol Chem (2005) 0.96
Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Cancer Res (2012) 0.95
Sequential one-pot glycosylations using 1-hydroxyl and 1-thiodonors. Org Lett (2003) 0.94
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. J Biol Chem (2002) 0.94
Conjugation of nucleosides and oligonucleotides by [3+2] cycloaddition. J Org Chem (2007) 0.93
Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides. Mol Pharmacol (2007) 0.93
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1. Nucleic Acids Res (2011) 0.93
Telomeric localization of the modified DNA base J in the genome of the protozoan parasite Leishmania. Nucleic Acids Res (2007) 0.91
Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo. Gastroenterology (2009) 0.90
Drug resistance in the mouse cancer clinic. Drug Resist Updat (2012) 0.89
The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res (2005) 0.89
The C-terminal region of Escherichia coli UvrC contributes to the flexibility of the UvrABC nucleotide excision repair system. Nucleic Acids Res (2002) 0.89
Trypanosomes change their transferrin receptor expression to allow effective uptake of host transferrin. Mol Microbiol (2005) 0.88
ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun (2011) 0.88
Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo. Cell Cycle (2010) 0.87
Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays. FASEB J (2011) 0.87
The physiological significance of transferrin receptor variations in Trypanosoma brucei. Mol Biochem Parasitol (2002) 0.87
Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sites. Mol Biochem Parasitol (2002) 0.85
The expression level determines the surface distribution of the transferrin receptor in Trypanosoma brucei. Mol Microbiol (2003) 0.85
Surface plasmon resonance evaluation of various aminoglycoside-RNA hairpin interactions reveals low degree of selectivity. Chembiochem (2004) 0.85
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm. Biochem J (2007) 0.84
Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA. Evidence for both major and minor groove contacts. J Biol Chem (2002) 0.84
1,3-Dimethyllumazine derivatives from Limnatis nilotica. J Nat Prod (2005) 0.84
Synthesis of sugar nucleotides by application of phosphoramidites. J Org Chem (2008) 0.84
N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2. J Med Chem (2014) 0.84
Synthesis and elaboration of functionalised carbohydrate-derived spiroketals. Org Biomol Chem (2004) 0.83
Structure of an anti-Lewis X Fab fragment in complex with its Lewis X antigen. Structure (2004) 0.82
Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding. J Am Chem Soc (2012) 0.82
EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors. PLoS One (2012) 0.82
Synthesis and biological evaluation of novel turn-modified gramicidin S analogues. Bioorg Med Chem (2003) 0.82
Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei. Mol Biochem Parasitol (2003) 0.81
Effect of bulky lesions on DNA: solution structure of a DNA duplex containing a cholesterol adduct. J Biol Chem (2004) 0.81
Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases. DNA Repair (Amst) (2004) 0.81
A novel strategy towards the synthesis of orthogonally functionalised 4-aminoglycosides. Org Biomol Chem (2003) 0.80
Synthesis and in vitro evaluation of PNA-peptide-DETA conjugates as potential cell penetrating artificial ribonucleases. Bioconjug Chem (2004) 0.80
Peptidomimetic glutathione analogues as novel gammaGT stable GST inhibitors. Bioorg Med Chem (2002) 0.79
Parasitology: switching like for like. Nature (2006) 0.79
A short route toward chiral, polyhydroxylated indolizidines and quinolizidines. J Org Chem (2003) 0.79
The beta-glucuronyl-based prodrug strategy allows for its application on beta-glucuronyl-platinum conjugates. Bioorg Med Chem Lett (2004) 0.78
Confirmation of the D configuration of the 2-substituted arabinitol 1-phosphate residue in the capsular polysaccharide from Streptococcus pneumoniae Type 17F. Carbohydr Res (2002) 0.78
Automated parallel solid-phase synthesis and anticancer screening of a library of peptide-tethered platinum(II) complexes. J Comb Chem (2003) 0.78
Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs. Mol Pharmacol (2002) 0.78
ssPNA templated assembly of oligo(p-phenylenevinylene)s. Chem Commun (Camb) (2009) 0.78
Monofunctionally trans-diammine platinum(II)-modified peptide nucleic acid oligomers: a new generation of potential antisense drugs. Chemistry (2002) 0.78
A targeted peptide nucleic acid to down-regulate mouse microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug Chem (2003) 0.77
Automated solid phase synthesis of teichoic acids. Chem Commun (Camb) (2011) 0.77
Analysis of telomere length variation in Leishmania over time. Mol Biochem Parasitol (2006) 0.77
The interaction of peptide-tethered platinum(II) complexes with DNA. J Inorg Biochem (2003) 0.77
A versatile approach towards regioselective platinated DNA sequences. Chemistry (2003) 0.77
Mega-dose vitamin C as therapy for human cancer? Proc Natl Acad Sci U S A (2008) 0.75
Antiproliferative effect in chronic myeloid leukaemia cells by antisense peptide nucleic acids. Nucleic Acids Res (2002) 0.75
Improvement of hepatocyte-specific gene expression by a targeted colchicine prodrug. Chembiochem (2003) 0.75
Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors. Bioorg Med Chem Lett (2003) 0.75
The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes. ACS Chem Biol (2016) 0.75
Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal beta-hexosaminidases. Bioorg Med Chem (2004) 0.75
Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1. J Med Chem (2004) 0.75
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure. J Am Chem Soc (2003) 0.75
The use of a mannitol-derived fused oxacycle as a combinatorial scaffold. J Org Chem (2003) 0.75