PubRank

Ernest Fraenkel

Author PubWeight™ 162.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 2002 43.52
2 Transcriptional regulatory code of a eukaryotic genome. Nature 2004 27.21
3 Control of pancreas and liver gene expression by HNF transcription factors. Science 2004 12.05
4 An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics 2006 11.13
5 Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet 2007 6.92
6 Computational discovery of gene modules and regulatory networks. Nat Biotechnol 2003 6.55
7 Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007 5.81
8 High-resolution computational models of genome binding events. Nat Biotechnol 2006 3.74
9 Core transcriptional regulatory circuitry in human hepatocytes. Mol Syst Biol 2006 3.15
10 Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet 2009 3.06
11 Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 2009 3.05
12 HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 2012 2.94
13 Practical strategies for discovering regulatory DNA sequence motifs. PLoS Comput Biol 2006 2.53
14 A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data. Bioinformatics 2005 2.52
15 Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech 2009 2.16
16 Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks. Sci Signal 2009 2.04
17 Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell 2012 1.71
18 A quantitative model of transcriptional regulation reveals the influence of binding location on expression. PLoS Comput Biol 2010 1.66
19 TAMO: a flexible, object-oriented framework for analyzing transcriptional regulation using DNA-sequence motifs. Bioinformatics 2005 1.63
20 Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol 2010 1.45
21 Genome-wide profiling of H3K56 acetylation and transcription factor binding sites in human adipocytes. PLoS One 2011 1.34
22 SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet 2013 1.32
23 Extensive changes in DNA methylation are associated with expression of mutant huntingtin. Proc Natl Acad Sci U S A 2013 1.28
24 ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data. Nucleic Acids Res 2011 1.28
25 Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3. Sci Signal 2011 1.27
26 Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development. Development 2010 1.21
27 SteinerNet: a web server for integrating 'omic' data to discover hidden components of response pathways. Nucleic Acids Res 2012 1.11
28 Simultaneous reconstruction of multiple signaling pathways via the prize-collecting steiner forest problem. J Comput Biol 2013 1.10
29 WebMOTIFS: automated discovery, filtering and scoring of DNA sequence motifs using multiple programs and Bayesian approaches. Nucleic Acids Res 2007 1.07
30 Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling. PLoS Comput Biol 2013 1.06
31 The small molecule, genistein, increases hepcidin expression in human hepatocytes. Hepatology 2013 1.00
32 Targeting H3K4 trimethylation in Huntington disease. Proc Natl Acad Sci U S A 2013 0.98
33 SAMNet: a network-based approach to integrate multi-dimensional high throughput datasets. Integr Biol (Camb) 2012 0.98
34 Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1. J Huntingtons Dis 2012 0.91
35 Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance. Cell Rep 2013 0.85
36 Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells 2015 0.84
37 Sequence analysis of chromatin immunoprecipitation data for transcription factors. Methods Mol Biol 2010 0.81
38 Integrated network analyses for functional genomic studies in cancer. Semin Cancer Biol 2013 0.80
39 Sharing information to reconstruct patient-specific pathways in heterogeneous diseases. Pac Symp Biocomput 2014 0.79
40 Swimming upstream: identifying proteomic signals that drive transcriptional changes using the interactome and multiple "-omics" datasets. Methods Cell Biol 2012 0.79
41 Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia. Integr Biol (Camb) 2016 0.75