Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.

PubWeight™: 3.06‹?› | Rank: Top 1%

🔗 View Article (PMC 2733244)

Published in Nat Genet on February 22, 2009

Authors

Esti Yeger-Lotem1, Laura Riva, Linhui Julie Su, Aaron D Gitler, Anil G Cashikar, Oliver D King, Pavan K Auluck, Melissa L Geddie, Julie S Valastyan, David R Karger, Susan Lindquist, Ernest Fraenkel

Author Affiliations

1: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Articles citing this

(truncated to the top 100)

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J Biol Chem (2009) 3.29

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. PLoS Biol (2011) 2.70

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron (2014) 2.69

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61

Integrative approaches for finding modular structure in biological networks. Nat Rev Genet (2013) 2.19

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16

Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks. Sci Signal (2009) 2.04

Studying and modelling dynamic biological processes using time-series gene expression data. Nat Rev Genet (2012) 2.01

Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00

DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila. Nucleic Acids Res (2010) 1.86

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (2013) 1.85

Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A (2010) 1.73

Identifying causal genes and dysregulated pathways in complex diseases. PLoS Comput Biol (2011) 1.65

Computational solutions for omics data. Nat Rev Genet (2013) 1.58

Chapter 5: Network biology approach to complex diseases. PLoS Comput Biol (2012) 1.45

Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. PLoS Genet (2011) 1.40

RNA-binding proteins with prion-like domains in ALS and FTLD-U. Prion (2011) 1.40

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity. J Neurosci (2012) 1.32

ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data. Nucleic Acids Res (2011) 1.28

From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases. Semin Immunopathol (2012) 1.21

On a fundamental structure of gene networks in living cells. Proc Natl Acad Sci U S A (2012) 1.21

Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods (2013) 1.19

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity. Hum Mol Genet (2012) 1.15

The yeast deletion collection: a decade of functional genomics. Genetics (2014) 1.15

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A (2012) 1.14

Linking the signaling cascades and dynamic regulatory networks controlling stress responses. Genome Res (2012) 1.14

SteinerNet: a web server for integrating 'omic' data to discover hidden components of response pathways. Nucleic Acids Res (2012) 1.11

Simultaneous reconstruction of multiple signaling pathways via the prize-collecting steiner forest problem. J Comput Biol (2013) 1.10

Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling. PLoS Comput Biol (2013) 1.06

Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem (2013) 1.05

Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology. Mol Microbiol (2012) 1.02

Network analysis of GWAS data. Curr Opin Genet Dev (2013) 1.02

Modeling information flow in biological networks. Phys Biol (2011) 1.02

Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Mol Med (2009) 1.00

Relating protein adduction to gene expression changes: a systems approach. Mol Biosyst (2011) 0.99

SAMNet: a network-based approach to integrate multi-dimensional high throughput datasets. Integr Biol (Camb) (2012) 0.98

Systems biological approaches to measure and understand vaccine immunity in humans. Semin Immunol (2013) 0.98

Annotating individual human genomes. Genomics (2011) 0.97

BSQA: integrated text mining using entity relation semantics extracted from biological literature of insects. Nucleic Acids Res (2010) 0.97

Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. PLoS Genet (2014) 0.96

Engineering enhanced protein disaggregases for neurodegenerative disease. Prion (2015) 0.96

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Hum Mol Genet (2014) 0.95

Model organisms reveal insight into human neurodegenerative disease: ataxin-2 intermediate-length polyglutamine expansions are a risk factor for ALS. J Mol Neurosci (2011) 0.95

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. J Biol Chem (2010) 0.94

Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. PLoS One (2011) 0.94

Fundamentals of protein interaction network mapping. Mol Syst Biol (2015) 0.93

From data towards knowledge: revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data. PLoS One (2013) 0.93

Large-scale elucidation of drug response pathways in humans. J Comput Biol (2012) 0.93

Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach. BMC Genomics (2011) 0.93

Reconstructing Boolean models of signaling. J Comput Biol (2013) 0.93

The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. PLoS One (2012) 0.93

Physical Module Networks: an integrative approach for reconstructing transcription regulation. Bioinformatics (2011) 0.92

TDP-43 toxicity in yeast. Methods (2010) 0.91

Genetic modifiers of neurological disease. Curr Opin Genet Dev (2011) 0.91

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes Dev (2015) 0.91

Identifying proteins controlling key disease signaling pathways. Bioinformatics (2013) 0.90

ResponseNet2.0: Revealing signaling and regulatory pathways connecting your proteins and genes--now with human data. Nucleic Acids Res (2013) 0.90

Pathway connectivity and signaling coordination in the yeast stress-activated signaling network. Mol Syst Biol (2014) 0.90

Statistical analysis reveals co-expression patterns of many pairs of genes in yeast are jointly regulated by interacting loci. PLoS Genet (2013) 0.90

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress. Cell Mol Life Sci (2010) 0.89

Global analysis of condition-specific subcellular protein distribution and abundance. Mol Cell Proteomics (2013) 0.89

Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? Cancer Biol Ther (2010) 0.89

EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population. Parkinsonism Relat Disord (2014) 0.89

Bridging the Gap between Genotype and Phenotype via Network Approaches. Front Genet (2013) 0.88

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. FASEB J (2013) 0.88

Dynamics of the Saccharomyces cerevisiae transcriptome during bread dough fermentation. Appl Environ Microbiol (2013) 0.87

Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms. BMC Genomics (2012) 0.87

Modeling Huntington disease in yeast: perspectives and future directions. Prion (2011) 0.86

Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Mol Biol Cell (2013) 0.86

Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration. Front Oncol (2012) 0.85

Identification of aberrant pathways and network activities from high-throughput data. Brief Bioinform (2012) 0.85

YTRP: a repository for yeast transcriptional regulatory pathways. Database (Oxford) (2014) 0.85

Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae. Oxid Med Cell Longev (2012) 0.85

A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders. Neurotherapeutics (2012) 0.84

Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts. Parkinsons Dis (2011) 0.84

Characterizing regulatory path motifs in integrated networks using perturbational data. Genome Biol (2010) 0.84

Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease. Neurobiol Aging (2014) 0.83

MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts. Nucleic Acids Res (2015) 0.83

Linking transcriptional changes over time in stimulated dendritic cells to identify gene networks activated during the innate immune response. PLoS Comput Biol (2013) 0.83

Revealing disease-associated pathways by network integration of untargeted metabolomics. Nat Methods (2016) 0.83

Genomics and bioinformatics of Parkinson's disease. Cold Spring Harb Perspect Med (2012) 0.82

SAMNetWeb: identifying condition-specific networks linking signaling and transcription. Bioinformatics (2014) 0.81

Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biol (2016) 0.81

Toward stem cell-based phenotypic screens for neurodegenerative diseases. Nat Rev Neurol (2015) 0.81

Experimental design schemes for learning Boolean network models. Bioinformatics (2014) 0.81

Dissecting cancer heterogeneity with a probabilistic genotype-phenotype model. Nucleic Acids Res (2013) 0.81

Network-Based Interpretation of Diverse High-Throughput Datasets through the Omics Integrator Software Package. PLoS Comput Biol (2016) 0.81

Using graph models to find transcription factor modules: the hitting set problem and an exact algorithm. Algorithms Mol Biol (2013) 0.80

TimeXNet: identifying active gene sub-networks using time-course gene expression profiles. BMC Syst Biol (2014) 0.80

The benefits of humanized yeast models to study Parkinson's disease. Oxid Med Cell Longev (2013) 0.80

Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project. J Transl Med (2014) 0.80

Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease. Drug Discov Today Technol (2013) 0.80

Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model. BMC Bioinformatics (2016) 0.80

Swimming upstream: identifying proteomic signals that drive transcriptional changes using the interactome and multiple "-omics" datasets. Methods Cell Biol (2012) 0.79

Contribution of yeast models to neurodegeneration research. J Biomed Biotechnol (2012) 0.78

Evaluating diabetes and hypertension disease causality using mouse phenotypes. BMC Syst Biol (2010) 0.78

A context-sensitive framework for the analysis of human signalling pathways in molecular interaction networks. Bioinformatics (2013) 0.78

Top-down network analysis to drive bottom-up modeling of physiological processes. J Comput Biol (2013) 0.77

TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast. PLoS One (2011) 0.77

Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins. Front Mol Neurosci (2015) 0.77

Articles cited by this

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25

Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09

Network motifs: simple building blocks of complex networks. Science (2002) 35.80

Functional discovery via a compendium of expression profiles. Cell (2000) 31.39

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science (1997) 28.30

Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21

Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science (2001) 24.48

Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62

Global mapping of the yeast genetic interaction network. Science (2004) 21.34

Alpha-synuclein in Lewy bodies. Nature (1997) 20.83

alpha-Synuclein locus triplication causes Parkinson's disease. Science (2003) 20.20

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31

A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60

MIPS: a database for genomes and protein sequences. Nucleic Acids Res (2002) 11.98

An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics (2006) 11.13

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell (2006) 8.61

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72

Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell (2001) 6.39

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J Biol (2006) 5.57

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell (1998) 5.52

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem (2006) 5.39

Systematic interpretation of genetic interactions using protein networks. Nat Biotechnol (2005) 5.38

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol (2007) 4.75

Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69

Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol (2008) 4.58

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature (2006) 4.54

Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51

Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (2003) 4.45

Discovery of biological networks from diverse functional genomic data. Genome Biol (2005) 3.73

A global view of pleiotropy and phenotypically derived gene function in yeast. Mol Syst Biol (2005) 3.70

Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction. Proc Natl Acad Sci U S A (2004) 3.60

A systems approach to mapping DNA damage response pathways. Science (2006) 3.55

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol Cell (2004) 3.26

Multiple knockout analysis of genetic robustness in the yeast metabolic network. Nat Genet (2006) 3.25

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85

Integrating physical and genetic maps: from genomes to interaction networks. Nat Rev Genet (2007) 2.77

Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci U S A (2002) 2.72

Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery. Neuron (2006) 2.66

Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci U S A (2006) 2.59

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron (2003) 2.49

eQED: an efficient method for interpreting eQTL associations using protein networks. Mol Syst Biol (2008) 2.45

Physical network models. J Comput Biol (2004) 2.44

Manganese-induced parkinsonism and Parkinson's disease. Ann N Y Acad Sci (2004) 2.25

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease. Mov Disord (2007) 2.24

Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 2.09

Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 1.90

Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol (2004) 1.90

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol (2006) 1.88

Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science (2008) 1.82

Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein. Mol Cell (2002) 1.82

An integrative approach for causal gene identification and gene regulatory pathway inference. Bioinformatics (2006) 1.82

Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Mol Cell (2004) 1.81

Dissection of transient oxidative stress response in Saccharomyces cerevisiae by using DNA microarrays. Mol Biol Cell (2002) 1.81

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.78

A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. J Cell Sci (2007) 1.70

Life cycles of successful genes. Trends Genet (2003) 1.61

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. J Biol Chem (2004) 1.60

SPINE: a framework for signaling-regulatory pathway inference from cause-effect experiments. Bioinformatics (2007) 1.60

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J Mol Biol (2005) 1.51

Genome-wide responses to DNA-damaging agents. Annu Rev Microbiol (2005) 1.48

Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor. Mol Cell Biol (2007) 1.43

From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions. Mol Syst Biol (2008) 1.35

A systems-level approach to mapping the telomere length maintenance gene circuitry. Mol Syst Biol (2008) 1.27

Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study. Mov Disord (2008) 1.26

To die or grow: Parkinson's disease and cancer. Trends Neurosci (2005) 1.25

Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathol Appl Neurobiol (2008) 1.17

Expression and functional profiling reveal distinct gene classes involved in fatty acid metabolism. Mol Syst Biol (2006) 1.16

Fzf1p regulates an inducible response to nitrosative stress in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.15

Physiological and pathological properties of alpha-synuclein. Cell Mol Life Sci (2007) 1.14

Parkin and defective ubiquitination in Parkinson's disease. J Neural Transm Suppl (2006) 1.13

A computational framework for the topological analysis and targeted disruption of signal transduction networks. Biophys J (2006) 1.12

NO-mediated apoptosis in yeast. J Cell Sci (2007) 1.11

Glycogen synthase phosphatase interacts with heat shock factor to activate CUP1 gene transcription in Saccharomyces cerevisiae. Mol Cell Biol (1999) 0.95

A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1. Mol Biol Cell (2005) 0.94

Articles by these authors

Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52

Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21

Characterizing gene sets with FuncAssociate. Bioinformatics (2003) 14.10

Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05

An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics (2006) 11.13

Hsp90 as a capacitor of phenotypic variation. Nature (2002) 8.90

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell (2007) 8.84

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72

HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16

Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet (2007) 6.92

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56

Computational discovery of gene modules and regulatory networks. Nat Biotechnol (2003) 6.55

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20

Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature (2010) 5.26

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science (2005) 5.04

Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90

Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (2003) 4.45

A neuronal isoform of the aplysia CPEB has prion-like properties. Cell (2003) 4.16

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature (2013) 4.03

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science (2004) 4.01

Prions as adaptive conduits of memory and inheritance. Nat Rev Genet (2005) 3.97

High-resolution computational models of genome binding events. Nat Biotechnol (2006) 3.74

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet (2009) 3.59

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A (2008) 3.46

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell (2012) 3.44

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39

Intensity-based protein identification by machine learning from a library of tandem mass spectra. Nat Biotechnol (2004) 3.30

A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast (2007) 3.30

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J Biol Chem (2009) 3.29

Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18

Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science (2013) 3.15

Core transcriptional regulatory circuitry in human hepatocytes. Mol Syst Biol (2006) 3.15

Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science (2002) 3.05

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res (2012) 3.00

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell (2012) 2.94

α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol (2010) 2.93

Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature (2012) 2.89

Stress granules as crucibles of ALS pathogenesis. J Cell Biol (2013) 2.80

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79

Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest (2003) 2.76

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. PLoS Biol (2011) 2.70

Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol (2005) 2.68

A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci U S A (2011) 2.68

Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science (2010) 2.68

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66

Semaphorin-plexin signaling guides patterning of the developing vasculature. Dev Cell (2004) 2.62

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci U S A (2007) 2.62

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61

Prion switching in response to environmental stress. PLoS Biol (2008) 2.61

Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci U S A (2006) 2.59

Prion recognition elements govern nucleation, strain specificity and species barriers. Nature (2007) 2.57

Practical strategies for discovering regulatory DNA sequence motifs. PLoS Comput Biol (2006) 2.53

Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52

A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data. Bioinformatics (2005) 2.52

Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Dev Biol (2005) 2.49

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci U S A (2009) 2.35

Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci (2010) 2.29

Prions as protein-based genetic elements. Annu Rev Microbiol (2002) 2.21

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell (2006) 2.14

Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell (2006) 2.09

Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks. Sci Signal (2009) 2.04

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A (2011) 2.03

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays (2004) 2.02

The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain (2011) 2.01

Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00

Predicting co-complexed protein pairs using genomic and proteomic data integration. BMC Bioinformatics (2004) 2.00

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science (2002) 1.99

The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A (2007) 1.99

A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A (2006) 1.92

Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets (2009) 1.91

Fitness trade-offs restrict the evolution of resistance to amphotericin B. PLoS Biol (2013) 1.88

Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet (2010) 1.88

Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci U S A (2008) 1.88

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci U S A (2008) 1.87

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (2013) 1.85

Widespread regulation of translation by elongation pausing in heat shock. Mol Cell (2013) 1.85

A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci U S A (2006) 1.85

Pharmacological prevention of Parkinson disease in Drosophila. Nat Med (2002) 1.84

Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits. Science (2010) 1.84

Local RNA translation at the synapse and in disease. J Neurosci (2011) 1.83