Published in Am J Pathol on November 30, 2009
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61
The role of macrophage phenotype in vascularization of tissue engineering scaffolds. Biomaterials (2014) 2.04
Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am J Pathol (2011) 1.37
Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. Matrix Biol (2015) 1.15
Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor. J Immunol (2011) 1.07
Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning. Cytokine Growth Factor Rev (2013) 1.05
Do anti-angiogenic VEGF (VEGFxxxb) isoforms exist? A cautionary tale. PLoS One (2012) 1.02
Specific VEGF sequestering and release using peptide-functionalized hydrogel microspheres. Biomaterials (2012) 1.02
Lipocalin 2 is a novel regulator of angiogenesis in human breast cancer. FASEB J (2012) 0.94
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils. Cytokine (2012) 0.90
Neutrophils in Cancer: Two Sides of the Same Coin. J Immunol Res (2015) 0.90
Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy. PLoS One (2013) 0.88
Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway. Stem Cells Dev (2014) 0.85
Endothelial precursor cells promote angiogenesis in hepatocellular carcinoma. World J Gastroenterol (2012) 0.84
Sequential Therapy with Minocycline and Candesartan Improves Long-Term Recovery After Experimental Stroke. Transl Stroke Res (2015) 0.83
Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability. Lab Invest (2014) 0.82
Neutrophil migration into the placenta: Good, bad or deadly? Cell Adh Migr (2016) 0.81
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy. Mol Vis (2016) 0.79
Strain variation in response to lung ischemia: role of MMP-12. Respir Res (2012) 0.79
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves the antiangiogenic efficacy for advanced stage mouse corneal neovascularization. Graefes Arch Clin Exp Ophthalmol (2011) 0.79
Matrix Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Aqueous Humor of Diabetic Macular Edema Patients. PLoS One (2016) 0.78
Paxillin regulates vascular endothelial growth factor A-induced in vitro angiogenesis of human umbilical vein endothelial cells. Mol Med Rep (2014) 0.77
ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer. PLoS One (2016) 0.76
Neutrophil count and percentage: potential independent prognostic indicators for advanced cancer patients in a palliative care setting. Oncotarget (2017) 0.75
Blockade of MMP-2 and MMP-9 inhibits corneal lymphangiogenesis. Graefes Arch Clin Exp Ophthalmol (2017) 0.75
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29
Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29
Matrix metalloproteinases. J Biol Chem (1999) 12.08
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell (2008) 8.01
Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer (2006) 5.58
Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer (2002) 5.57
The matrix-degrading metalloproteinases. Bioessays (1992) 4.84
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res (1998) 4.39
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A (2000) 4.22
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol (2005) 4.03
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell (1998) 3.72
Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell (2008) 3.56
A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci (1996) 3.49
The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol (2001) 3.22
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nat Med (2003) 3.20
Matrix metalloproteinases and angiogenesis. J Cell Mol Med (2005) 2.89
TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. Cell (2003) 2.87
Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. Am J Pathol (2002) 2.27
Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. Cancer Res (2003) 2.14
Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2006) 2.12
Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. Circ Res (1998) 2.06
The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis. Surg Oncol Clin N Am (2001) 1.77
Matrix metalloproteinases as valid clinical targets. Curr Pharm Des (2007) 1.76
The mouse cornea micropocket angiogenesis assay. Nat Protoc (2007) 1.74
Human endothelial gelatinases and angiogenesis. Int J Biochem Cell Biol (2001) 1.67
Matrix metalloproteinases: old dogs with new tricks. Genome Biol (2003) 1.59
Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc Res (1998) 1.55
Diminished corneal angiogenesis in gelatinase A-deficient mice. FEBS Lett (2001) 1.44
VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol (2004) 1.39
RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis. Cancer Res (2007) 1.39
Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain. J Neuropathol Exp Neurol (1999) 1.35
Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface. J Cell Sci (2004) 1.34
Positive feedback regulation between MMP-9 and VEGF in human RPE cells. Invest Ophthalmol Vis Sci (2007) 1.32
Extracellular proteolysis and angiogenesis. Thromb Haemost (2001) 1.12
Matrix metalloproteinase-9 contributes to choroidal neovascularization. Am J Pathol (2002) 1.10
Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Enzyme Protein (1996) 1.09
Metalloproteinases and their inhibitors in angiogenesis. Expert Rev Mol Med (2003) 1.06
Active and tissue inhibitor of matrix metalloproteinase-free gelatinase B accumulates within human microvascular endothelial vesicles. J Biol Chem (1998) 1.06
Vascular endothelial growth factor activating matrix metalloproteinase in ascitic fluid during peritoneal dissemination of ovarian cancer. Oncol Rep (2002) 1.01
MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina (2006) 1.00
Vascular endothelial growth factor stimulates organ-specific host matrix metalloproteinase-9 expression and ovarian cancer invasion. Mol Cancer Res (2008) 0.99
Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2. Oncol Rep (2006) 0.97
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR. Invest Ophthalmol Vis Sci (2007) 0.95
Growth factor gradients in vascular patterning. Novartis Found Symp (2007) 0.94
Dexamethasone treatment and ICAM-1 deficiency impair VEGF-induced angiogenesis in adult brain. J Vasc Res (2007) 0.90
Selective killing of RPE with a vascular endothelial growth factor chimeric toxin. Invest Ophthalmol Vis Sci (2000) 0.90
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med (2009) 4.83
Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell (2010) 3.82
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 3.28
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nat Med (2003) 3.20
Oxidative stress and antioxidant defense. World Allergy Organ J (2012) 2.35
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 2.09
Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities. Blood (2011) 2.08
Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biol (2006) 2.05
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol (2008) 1.90
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell (2010) 1.87
Three-dimensional structure of the human cytomegalovirus cytoplasmic virion assembly complex includes a reoriented secretory apparatus. J Virol (2007) 1.73
Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res (2005) 1.68
VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J (2005) 1.63
Corneal wound healing after ultraviolet-A/riboflavin collagen cross-linking: a rabbit study. J Refract Surg (2010) 1.60
Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A (2006) 1.59
IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med (2006) 1.57
Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model. J Orthop Res (2008) 1.52
Apoptosis in the initiation, modulation and termination of the corneal wound healing response. Exp Eye Res (2007) 1.45
A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev Biol (2010) 1.44
Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation. PLoS One (2013) 1.43
Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res (2003) 1.41
Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Dis Model Mech (2012) 1.38
A role for caveolae in cell migration. FASEB J (2004) 1.38
Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Mol Biol Cell (2005) 1.32
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations. J Biol Chem (2004) 1.32
Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions. Mol Biol Cell (2003) 1.31
Corneal myofibroblast generation from bone marrow-derived cells. Exp Eye Res (2010) 1.31
Topical interleukin-1 receptor antagonist inhibits inflammatory cell infiltration into the cornea. Exp Eye Res (2008) 1.29
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One (2011) 1.29
Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol (2009) 1.27
Multiple myeloma biology: lessons from the 5TMM models. Immunol Rev (2003) 1.27
Human primary lung endothelial cells in culture. Am J Respir Cell Mol Biol (2012) 1.24
Dual regulation of cryptochrome 1 mRNA expression in chicken retina by light and circadian oscillators. Neuroreport (2002) 1.23
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med (2013) 1.21
Meibum lipid composition in Asians with dry eye disease. PLoS One (2011) 1.16
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells. Clin Exp Metastasis (2002) 1.16
Femtosecond lenticule extraction (FLEx): clinical results, interface evaluation, and intraocular pressure variation. Invest Ophthalmol Vis Sci (2012) 1.16
ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Matrix Biol (2007) 1.15
Membrane microviscosity regulates endothelial cell motility. Nat Cell Biol (2002) 1.14
Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc Natl Acad Sci U S A (2008) 1.12
Early corneal wound healing and inflammatory responses after refractive lenticule extraction (ReLEx). Invest Ophthalmol Vis Sci (2011) 1.12
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood (2005) 1.11
Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc (2013) 1.11
Effects of the menstrual cycle on lung function variables in women with asthma. Am J Respir Crit Care Med (2009) 1.10
Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem (2011) 1.09
Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload. FASEB J (2012) 1.09
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med (2010) 1.09
Differentiated murine airway epithelial cells synthesize a leukocyte-adhesive hyaluronan matrix in response to endoplasmic reticulum stress. J Biol Chem (2008) 1.08
S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis. J Biol Chem (2009) 1.08
Corneal stroma PDGF blockade and myofibroblast development. Exp Eye Res (2008) 1.08
Comparison of four different VisuMax circle patterns for flap creation after small incision lenticule extraction. J Refract Surg (2013) 1.06
Corneal myofibroblast viability: opposing effects of IL-1 and TGF beta1. Exp Eye Res (2009) 1.06
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr Relat Cancer (2013) 1.06
Early corneal nerve damage and recovery following small incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK). Invest Ophthalmol Vis Sci (2014) 1.05
ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Matrix Biol (2003) 1.04
MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents. Cancer Res (2011) 1.04
Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells. J Neurochem (2009) 1.03
Stromal cell-derived factor-1 and monocyte chemotactic protein-3 improve recruitment of osteogenic cells into sites of musculoskeletal repair. J Orthop Res (2011) 1.03
Refractive lenticule re-implantation after myopic ReLEx: a feasibility study of stromal restoration after refractive surgery in a rabbit model. Invest Ophthalmol Vis Sci (2012) 1.03
Triamcinolone acetonide inhibits IL-6- and VEGF-induced angiogenesis downstream of the IL-6 and VEGF receptors. Invest Ophthalmol Vis Sci (2006) 0.99
Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. J Allergy Clin Immunol (2010) 0.97
A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion. J Leukoc Biol (2003) 0.97
Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One (2011) 0.97
The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model. Haematologica (2006) 0.96
Dopamine D₄ receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina. Eur J Neurosci (2011) 0.95
Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis. J Biol Chem (2002) 0.94
Effect of femtosecond laser energy level on corneal stromal cell death and inflammation. J Refract Surg (2009) 0.94
Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath (2011) 0.94
Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy. Exp Eye Res (2010) 0.94
Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes. J Biol Chem (2014) 0.94
Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. Mol Biol Cell (2012) 0.94
Spiral ganglion degeneration patterns in endolymphatic hydrops. Laryngoscope (2008) 0.93
Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore. Invest Ophthalmol Vis Sci (2010) 0.93
Cornea lenticule viability and structural integrity after refractive lenticule extraction (ReLEx) and cryopreservation. Mol Vis (2011) 0.93
Spatial distribution and extent of electroporation by strong internal shock in intact structurally normal and chronically infarcted rabbit hearts. J Cardiovasc Electrophysiol (2008) 0.93
Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells. J Cell Physiol (2011) 0.93
In vivo transplantation of autogenous marrow-derived cells following rapid intraoperative magnetic separation based on hyaluronan to augment bone regeneration. Tissue Eng Part A (2012) 0.92
Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells. J Neurosci (2006) 0.92
Temporal-spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues. J Neurochem (2003) 0.92
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem (2011) 0.92
Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy. Invest Ophthalmol Vis Sci (2013) 0.91
Bone regeneration in a rabbit critical-sized calvarial model using tyrosine-derived polycarbonate scaffolds. Tissue Eng Part A (2012) 0.90
Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina. Chronobiol Int (2006) 0.90
Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma. PLoS One (2010) 0.90
Pulmonary artery endothelium resident endothelial colony-forming cells in pulmonary arterial hypertension. Pulm Circ (2012) 0.90
Calcospherulites isolated from the mineralization front of bone induce the mineralization of type I collagen. Bone (2007) 0.90
Caveolin-1 polarization in transmigrating endothelial cells requires binding to intermediate filaments. Angiogenesis (2007) 0.89
Buffering airway acid decreases exhaled nitric oxide in asthma. J Allergy Clin Immunol (2006) 0.89
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J (2005) 0.89
Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium. PLoS One (2011) 0.89