Published in J Am Chem Soc on January 20, 2010
Surface structural-chemical characterization of a single-site d0 heterogeneous arene hydrogenation catalyst having 100% active sites. Proc Natl Acad Sci U S A (2012) 0.79
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol (2006) 3.12
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science (2009) 2.23
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol (2006) 1.86
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol (2004) 1.81
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity (2002) 1.77
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res (2003) 1.75
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood (2007) 1.60
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol (2004) 1.51
Portrait of PTEN: messages from mutant mice. Cancer Sci (2008) 1.44
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol (2009) 1.39
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation (2003) 1.36
Physiological functions of Pten in mouse tissues. Cell Struct Funct (2003) 1.36
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol (2003) 1.34
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res (2006) 1.29
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res (2008) 1.19
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation. J Neurosci (2007) 1.14
Immobilized metal ion-containing ionic liquids: preparation, structure and catalytic performance in Kharasch addition reaction. Chem Commun (Camb) (2005) 1.14
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
Dynamics of human erythroblast enucleation. Int J Hematol (2008) 1.11
Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. J Allergy Clin Immunol (2009) 1.11
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem (2003) 1.11
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem (2013) 1.10
JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem (2003) 1.09
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc Natl Acad Sci U S A (2012) 1.07
IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts. Bone (2008) 1.07
Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons. J Neurochem (2004) 1.06
The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS One (2011) 1.05
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J Biol Chem (2002) 1.04
Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A (2008) 1.02
Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem (2010) 1.01
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood (2006) 1.00
Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J Immunol (2008) 1.00
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol (2008) 1.00
Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol Res (2006) 0.99
A new PICTure of nucleolar stress. Cancer Sci (2012) 0.98
Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation. FEBS Lett (2003) 0.95
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport. J Bone Miner Res (2012) 0.95
Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun (2012) 0.93
Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A (2013) 0.91
CD45 regulated signaling pathways. Curr Top Med Chem (2003) 0.90
Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. J Biol Chem (2012) 0.90
LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol Biol Cell (2012) 0.90
SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J (2003) 0.89
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol (2008) 0.88
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc Natl Acad Sci U S A (2011) 0.88
Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells. J Biol Chem (2004) 0.88
Preparation and structure of a single Au atom on the TiO2(110) surface: control of the Au-metal oxide surface interaction. Faraday Discuss (2013) 0.87
Layered materials with coexisting acidic and basic sites for catalytic one-pot reaction sequences. J Am Chem Soc (2009) 0.87
LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. J Lipid Res (2011) 0.86
Oxygen vacancy promoting catalytic dehydration of formic acid on TiO2(110) by in situ scanning tunneling microscopic observation. J Phys Chem B (2005) 0.85
Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet (2012) 0.84
Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem (2002) 0.84
Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol Res (2009) 0.84
Heterogeneous organic base-catalyzed reactions enhanced by acid supports. J Am Chem Soc (2007) 0.84
Surface-mediated visible-light photo-oxidation on pure TiO(2)(001). J Am Chem Soc (2009) 0.83
Self-limiting growth of Pt nanoparticles from MeCpPtMe3 adsorbed on TiO2110 studied by scanning tunneling microscopy. Phys Rev Lett (2003) 0.82
Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions. J Biochem (2013) 0.81
Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology (2006) 0.81
The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation. Int Arch Allergy Immunol (2010) 0.81
Atomic Force Microscope Studies on Condensation of Plasmid DNA with Functionalized Fullerenes This research was supported by Grant-in-Aid for Specially Promoted Research from Ministry of Education, Culture, Sports, Science, and Technology. Angew Chem Int Ed Engl (2001) 0.81
5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration. Chembiochem (2010) 0.80
Surface junction effects on the electron conduction of molecular wires. J Am Chem Soc (2010) 0.80
The role of carbon dioxide in chemoselective hydrogenation of halonitroaromatics over supported noble metal catalysts in supercritical carbon dioxide. Chem Commun (Camb) (2004) 0.79
Acid-base bifunctional catalytic surfaces for nucleophilic addition reactions. Chem Asian J (2008) 0.79
Chiral self-dimerization of vanadium complexes on a SiO2 surface: the first heterogeneous catalyst for asymmetric 2-naphthol coupling. Chem Commun (Camb) (2004) 0.79
Energy-gaining formation and catalytic behavior of active structures in a SiO(2)-supported unsaturated Ru complex catalyst for alkene epoxidation by DFT calculations. Phys Chem Chem Phys (2007) 0.79
Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PLoS One (2011) 0.78
Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression. Endocr Relat Cancer (2013) 0.78
Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J Gastroenterol Hepatol (2011) 0.78
Preparation of surface molecularly imprinted Ru-complex catalysts for asymmetric transfer hydrogenation in water media. Dalton Trans (2010) 0.78
Time scale and elementary steps of CO-induced disintegration of surface rhodium clusters. Angew Chem Int Ed Engl (2003) 0.78
Assessment of the anatomical relationship between the arcuate eminence and superior semicircular canal by computed tomography. Neurol Med Chir (Tokyo) (2007) 0.78
A solid chelating ligand: periodic mesoporous organosilica containing 2,2'-bipyridine within the pore walls. J Am Chem Soc (2014) 0.77
In situ time-resolved DXAFS for the determination of kinetics of structural changes of H-ZSM-5-supported active Re-cluster catalyst in the direct phenol synthesis from benzene and O2. Phys Chem Chem Phys (2010) 0.77
Selective formation of a coordinatively unsaturated metal complex at a surface: a SiO(2)-immobilized, three-coordinate ruthenium catalyst for alkene epoxidation. Angew Chem Int Ed Engl (2007) 0.77
Oxide surface-promoted Pd-complex catalysis for intramolecular O-activated alkene hydroamination: catalyst preparation, characterization, and performance. Chem Commun (Camb) (2004) 0.77
Acid-base bifunctional catalysis of silica-alumina-supported organic amines for carbon-carbon bond-forming reactions. Chemistry (2008) 0.77
Selective oxidation of benzene to phenol with molecular oxygen on rhenium/zeolite catalysts. Chem Commun (Camb) (2004) 0.76
Advanced chemical design with supported metal complexes for selective catalysis. Chem Commun (Camb) (2006) 0.76
Gamma knife radiosurgery for skull-base meningiomas. Prog Neurol Surg (2009) 0.76
μ-XAFS of a single particle of a practical NiO(x)/Ce2Zr2O(y) catalyst. Phys Chem Chem Phys (2011) 0.76