Published in Proc Natl Acad Sci U S A on May 29, 2012
Allosteric substrate switching in a voltage-sensing lipid phosphatase. Nat Chem Biol (2016) 1.47
Depression of voltage-activated Ca2+ release in skeletal muscle by activation of a voltage-sensing phosphatase. J Gen Physiol (2015) 1.35
Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor. J Physiol (2013) 1.08
Voltage-Controlled Enzymes: The New JanusBifrons. Front Pharmacol (2012) 0.91
Interactions of phosphatase and tensin homologue (PTEN) proteins with phosphatidylinositol phosphates: insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase. Biochemistry (2014) 0.91
Sensing charges of the Ciona intestinalis voltage-sensing phosphatase. J Gen Physiol (2013) 0.90
Voltage-sensing phosphatase modulation by a C2 domain. Front Pharmacol (2015) 0.88
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
The linker pivot in Ci-VSP: the key to unlock catalysis. PLoS One (2013) 0.84
Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence. Proc Natl Acad Sci U S A (2016) 0.83
Functional diversity of voltage-sensing phosphatases in two urodele amphibians. Physiol Rep (2014) 0.81
A human phospholipid phosphatase activated by a transmembrane control module. J Lipid Res (2012) 0.81
Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research. Front Pharmacol (2015) 0.80
Detection and manipulation of phosphoinositides. Biochim Biophys Acta (2014) 0.79
Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid. Proc Natl Acad Sci U S A (2016) 0.78
Characterization of the Functional Domains of a Mammalian Voltage-Sensitive Phosphatase. Biophys J (2015) 0.76
How is SR calcium release in muscle modulated by PIP(4,5)2? J Gen Physiol (2015) 0.75
Simple scheme of lipid enzyme can explain complex lives of phosphoinositides. Proc Natl Acad Sci U S A (2016) 0.75
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
The multiple roles of PTEN in tumor suppression. Cell (2000) 6.71
PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem (2001) 3.78
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J (2000) 3.53
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol (1992) 2.53
Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2. J Physiol (2007) 2.31
Sequential signals toward podosome formation in NIH-src cells. J Cell Biol (2008) 2.18
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes (2002) 1.91
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem (2008) 1.83
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase. J Biol Chem (2008) 1.61
Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol (2009) 1.60
TPIP: a novel phosphoinositide 3-phosphatase. Biochem J (2001) 1.60
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res (2009) 1.48
PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase. J Biol Chem (2001) 1.39
Pten, tumorigenesis, and stem cell self-renewal. Cell (2006) 1.36
Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proc Natl Acad Sci U S A (2010) 1.28
Voltage-sensing phosphatase: its molecular relationship with PTEN. Physiology (Bethesda) (2011) 1.20
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J (2002) 1.08
Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence. J Cell Physiol (2011) 1.07
Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res (2010) 1.05
Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction. J Biol Chem (2003) 1.02
Membrane hyperpolarization by sperm-activating and -attracting factor increases cAMP level and activates sperm motility in the ascidian Ciona intestinalis. Dev Biol (1999) 0.96
Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian. Gene Expr Patterns (2010) 0.95
Kidney specific expression of cTPTE during development of the chick embryo. Gene Expr Patterns (2009) 0.89
Cell biology: watching the first steps of podosome formation. Curr Biol (2008) 0.85
New translation system of mRNA coding for neurotransmitter receptors using oocytes of the newt, Cynops pyrrhogaster. Brain Res (1986) 0.81
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron (2004) 5.95
A voltage sensor-domain protein is a voltage-gated proton channel. Science (2006) 5.07
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol (2006) 3.12
Improving membrane voltage measurements using FRET with new fluorescent proteins. Nat Methods (2008) 2.74
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev (2002) 2.61
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature (2003) 2.42
Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2. J Physiol (2007) 2.31
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science (2009) 2.23
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J Natl Cancer Inst (2005) 2.23
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. J Neurosci (2006) 2.09
Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A (2008) 2.00
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol (2006) 1.86
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85
Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem (2008) 1.83
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol (2004) 1.81
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity (2002) 1.77
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res (2003) 1.75
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol (2005) 1.69
Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience. Clin J Am Soc Nephrol (2011) 1.63
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood (2007) 1.60
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet (2008) 1.56
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol (2004) 1.51
Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res (2009) 1.48
Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J Clin Invest (2005) 1.46
Feasibility and accuracy of computational robot-assisted partial nephrectomy planning by virtual partial nephrectomy analysis. Int J Urol (2015) 1.44
Portrait of PTEN: messages from mutant mice. Cancer Sci (2008) 1.44
Voltage-gated proton channel is expressed on phagosomes. Biochem Biophys Res Commun (2009) 1.43
Maintenance monotherapy with gemcitabine after standard platinum-based chemotherapy in patients with advanced urothelial cancer. Int J Urol (2015) 1.43
Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet (2002) 1.43
Favorable risk factors in patients with positive surgical margin after robot-assisted radical prostatectomy. Can J Urol (2014) 1.40
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol (2009) 1.39
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation (2003) 1.36
Physiological functions of Pten in mouse tissues. Cell Struct Funct (2003) 1.36
Focal therapy with high-intensity-focused ultrasound in the treatment of localized prostate cancer. Jpn J Clin Oncol (2008) 1.36
Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7. J Lipid Res (2007) 1.35
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol (2003) 1.34
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. J Exp Med (2009) 1.29
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res (2006) 1.29
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
Prostate Cancer Working Group report. Jpn J Clin Oncol (2010) 1.25
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1. Nat Commun (2012) 1.23
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res (2008) 1.19
Functionality of the voltage-gated proton channel truncated in S4. Proc Natl Acad Sci U S A (2009) 1.18
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J Urol (2003) 1.18
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of Acyl-CoA synthetase. Biol Pharm Bull (2006) 1.15
Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation. J Neurosci (2007) 1.14
Prevalence of renal cell carcinoma: a nation-wide survey in Japan, 2002. Int J Urol (2007) 1.14
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease. Clin Exp Nephrol (2011) 1.12
Dynamics of human erythroblast enucleation. Int J Hematol (2008) 1.11
Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. J Allergy Clin Immunol (2009) 1.11
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem (2003) 1.11
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem (2013) 1.10
JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem (2003) 1.09
Seventh Joint Meeting of K-J-CaP and CaPSURE: extending the global initiative to improve prostate cancer management. Prostate Int (2014) 1.08
The physiology of phosphoinositides. Biol Pharm Bull (2007) 1.08
Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor. J Physiol (2013) 1.08
A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1. J Neurosci (2005) 1.08
Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence. J Cell Physiol (2011) 1.07
IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts. Bone (2008) 1.07
The neurobiology of the ascidian tadpole larva: recent developments in an ancient chordate. Annu Rev Neurosci (2004) 1.07
Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation (2005) 1.07
Regulation of Na v channels in sensory neurons. Trends Pharmacol Sci (2005) 1.07
Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons. J Neurochem (2004) 1.06
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest (2016) 1.05
The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS One (2011) 1.05
Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J Biol Chem (2002) 1.04
Significance of nocturia in the International Prostate Symptom Score for benign prostatic hyperplasia. J Urol (2002) 1.03
Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A (2008) 1.02
Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt. Biochem J (2005) 1.02
The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor. J Biol Chem (2007) 1.02
Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem (2010) 1.01
Coupling of the phosphatase activity of Ci-VSP to its voltage sensor activity over the entire range of voltage sensitivity. J Physiol (2011) 1.01
Improved detection of electrical activity with a voltage probe based on a voltage-sensing phosphatase. J Physiol (2013) 1.01
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood (2006) 1.00
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol (2008) 1.00