PubRank

Raghavendra G Mirmira

Author PubWeight™ 60.57‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem 2002 3.21
2 Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 2012 1.98
3 The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A 2005 1.88
4 Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A 2009 1.84
5 Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol 2009 1.74
6 Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem 2003 1.71
7 Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem 2005 1.65
8 Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem 2005 1.61
9 The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest 2010 1.57
10 Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol 2008 1.52
11 Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes 2008 1.46
12 Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes 2007 1.38
13 A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Mol Genet Metab 2007 1.38
14 An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. J Clin Invest 2010 1.36
15 Transcription factors direct the development and function of pancreatic beta cells. Trends Endocrinol Metab 2003 1.31
16 Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab 2008 1.28
17 Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes 2007 1.17
18 Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA. Endocrinology 2013 1.14
19 Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease. J Vis Exp 2012 1.12
20 Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol 2008 1.08
21 Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes. J Biol Chem 2010 1.06
22 The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Mol Endocrinol 2004 1.05
23 Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. J Biol Chem 2008 1.03
24 Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1. Mol Endocrinol 2006 1.02
25 Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Mol Endocrinol 2008 1.01
26 Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol 2010 0.99
27 The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol 2010 0.99
28 Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab 2014 0.93
29 Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem 2009 0.92
30 Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death. Mol Endocrinol 2012 0.92
31 Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells. Mol Endocrinol 2012 0.92
32 Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains. Am J Physiol Endocrinol Metab 2013 0.91
33 Expression and function of Set7/9 in pancreatic islets. Islets 2010 0.90
34 The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter. Biochemistry 2005 0.90
35 Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Cell Cycle 2011 0.89
36 Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One 2013 0.88
37 Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes 2011 0.87
38 Hypusine: a new target for therapeutic intervention in diabetic inflammation. Discov Med 2010 0.86
39 Inducible pluripotent stem cells: not quite ready for prime time? Curr Opin Organ Transplant 2010 0.86
40 AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol 2010 0.86
41 Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia 2016 0.85
42 Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study. Anal Biochem 2010 0.81
43 Characterization of a novel polyclonal anti-hypusine antibody. Springerplus 2013 0.80
44 Development of insulin-producing cells from primitive biologic precursors. Curr Opin Organ Transplant 2009 0.80
45 Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation. Curr Opin Organ Transplant 2009 0.80
46 Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine. Pancreas 2011 0.80
47 Mouse and human islets survive and function after coating by biosilicification. Am J Physiol Endocrinol Metab 2013 0.79
48 Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. Amino Acids 2013 0.77
49 Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response. Mol Endocrinol 2014 0.77
50 Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes. Am J Physiol Endocrinol Metab 2014 0.77
51 Saturated free fatty acids: islet β cell "stressERs". Endocrine 2012 0.77
52 Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes. J Biol Chem 2013 0.76
53 Achieving "PeaK-A" insulin secretion. Diabetes 2013 0.75
54 Insights into mentorship for endocrinologists. J Clin Endocrinol Metab 2012 0.75
55 Stem cells and the future of organ transplantation. Curr Opin Organ Transplant 2010 0.75
56 Editorial: in praise of scientific review officers. Mol Endocrinol 2014 0.75
57 Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep 2016 0.75