Published in Am J Physiol Endocrinol Metab on February 04, 2014
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer. Amino Acids (2016) 0.79
Hypusination of eIF5A as a Target for Antiviral Therapy. DNA Cell Biol (2017) 0.75
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet (2007) 7.01
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
Hypusine-containing protein eIF5A promotes translation elongation. Nature (2009) 2.99
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med (2012) 2.86
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The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis. Amino Acids (2001) 1.26
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol (2011) 1.25
Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion. Am J Physiol Endocrinol Metab (2000) 1.14
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Does GAD have a unique role in triggering IDDM? J Autoimmun (2000) 1.01
Hypusine: a new target for therapeutic intervention in diabetic inflammation. Discov Med (2010) 0.86
Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun (2009) 0.85
Diabetes-associated dry eye syndrome in a new humanized transgenic model of type 1 diabetes. Mol Vis (2013) 0.81
Glucose intolerance and diabetes following antigen-specific insulitis in diabetes-susceptible "humanized" transgenic mice. Biochem Biophys Res Commun (2010) 0.80
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem (2002) 3.21
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes (2012) 1.98
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A (2009) 1.84
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol (2009) 1.74
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem (2003) 1.71
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem (2005) 1.65
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem (2005) 1.61
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol (2008) 1.52
Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes (2008) 1.46
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Mol Genet Metab (2007) 1.38
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes (2007) 1.38
An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. J Clin Invest (2010) 1.36
Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf) (2008) 1.31
Transcription factors direct the development and function of pancreatic beta cells. Trends Endocrinol Metab (2003) 1.31
Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab (2008) 1.28
Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes (2007) 1.17
Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA. Endocrinology (2013) 1.14
Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease. J Vis Exp (2012) 1.12
Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol (2008) 1.08
Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes. J Biol Chem (2010) 1.06
The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Mol Endocrinol (2004) 1.05
Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. Thyroid Res (2010) 1.04
Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. J Biol Chem (2008) 1.03
Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1. Mol Endocrinol (2006) 1.02
Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Mol Endocrinol (2008) 1.01
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol (2010) 0.99
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol (2010) 0.99
Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab (2014) 0.93
Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem (2009) 0.92
Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells. Mol Endocrinol (2012) 0.92
Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death. Mol Endocrinol (2012) 0.92
Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains. Am J Physiol Endocrinol Metab (2013) 0.91
The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter. Biochemistry (2005) 0.90
Expression and function of Set7/9 in pancreatic islets. Islets (2010) 0.90
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Cell Cycle (2011) 0.89
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One (2013) 0.88
Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes (2011) 0.87
Inducible pluripotent stem cells: not quite ready for prime time? Curr Opin Organ Transplant (2010) 0.86
Failure of radioactive iodine in the treatment of hyperthyroidism. Ann Surg Oncol (2014) 0.86
Hypusine: a new target for therapeutic intervention in diabetic inflammation. Discov Med (2010) 0.86
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol (2010) 0.86
Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun (2009) 0.85
Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia (2016) 0.85
Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study. Anal Biochem (2010) 0.81
Development of insulin-producing cells from primitive biologic precursors. Curr Opin Organ Transplant (2009) 0.80
Glucose intolerance and diabetes following antigen-specific insulitis in diabetes-susceptible "humanized" transgenic mice. Biochem Biophys Res Commun (2010) 0.80
Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation. Curr Opin Organ Transplant (2009) 0.80
Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine. Pancreas (2011) 0.80
Characterization of a novel polyclonal anti-hypusine antibody. Springerplus (2013) 0.80
Mouse and human islets survive and function after coating by biosilicification. Am J Physiol Endocrinol Metab (2013) 0.79
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. Amino Acids (2013) 0.77
Saturated free fatty acids: islet β cell "stressERs". Endocrine (2012) 0.77
Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response. Mol Endocrinol (2014) 0.77
Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes. J Biol Chem (2013) 0.76
Achieving "PeaK-A" insulin secretion. Diabetes (2013) 0.75
Insights into mentorship for endocrinologists. J Clin Endocrinol Metab (2012) 0.75
Editorial: in praise of scientific review officers. Mol Endocrinol (2014) 0.75
Stem cells and the future of organ transplantation. Curr Opin Organ Transplant (2010) 0.75
Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep (2016) 0.75