Published in Diabetes on November 04, 2008
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol (2009) 1.74
Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev (2011) 1.69
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
Epigenetic phenomena linked to diabetic complications. Nat Rev Endocrinol (2010) 1.51
Genome-wide analysis of histone modifications in human pancreatic islets. Genome Res (2010) 1.51
Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res (2011) 1.43
12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets. J Clin Endocrinol Metab (2010) 1.31
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
SET7/9 mediated methylation of non-histone proteins in mammalian cells. Epigenetics (2009) 1.16
Prenatal androgen exposure programs metabolic dysfunction in female mice. J Endocrinol (2010) 1.13
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A (2014) 1.09
ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes (2012) 1.08
Epigenetic modifications in the pathogenesis of diabetic nephropathy. Semin Nephrol (2013) 1.02
The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. Mol Cell Biol (2009) 1.00
Early-life origins of type 2 diabetes: fetal programming of the beta-cell mass. Exp Diabetes Res (2011) 0.98
Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity. J Biol Chem (2013) 0.95
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes (2012) 0.95
Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome (2009) 0.92
Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes. Cell Mol Life Sci (2013) 0.91
Expression and function of Set7/9 in pancreatic islets. Islets (2010) 0.90
Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes. Vitam Horm (2013) 0.90
Transcriptional regulation by the Set7 lysine methyltransferase. Epigenetics (2013) 0.88
Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. Diabetes (2015) 0.82
Modeling a new water channel that allows SET9 to dimethylate p53. PLoS One (2011) 0.80
SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress. Open Biol (2013) 0.79
Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. J Biol Chem (2015) 0.78
Regulation of insulin gene transcription by multiple histone acetyltransferases. DNA Cell Biol (2011) 0.78
ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex. Cell Cycle (2015) 0.77
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell. J Biol Chem (2015) 0.77
Translational implications of the β-cell epigenome in diabetes mellitus. Transl Res (2014) 0.77
A systems view of epigenetic networks regulating pancreas development and β-cell function. Wiley Interdiscip Rev Syst Biol Med (2015) 0.76
A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets. J Proteomics (2013) 0.76
Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3. Diabetes (2009) 0.76
The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets. PLoS One (2015) 0.75
Epigenetic control of β-cell function and failure. Diabetes Res Clin Pract (2016) 0.75
Revealing inhibition difference between PFI-2 enantiomers against SETD7 by molecular dynamics simulations, binding free energy calculations and unbinding pathway analysis. Sci Rep (2017) 0.75
Set7 mediated interactions regulate transcriptional networks in embryonic stem cells. Nucleic Acids Res (2016) 0.75
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
Islet beta cell failure in type 2 diabetes. J Clin Invest (2006) 7.67
Cellular memory and the histone code. Cell (2002) 7.30
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes (2000) 6.27
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J (1993) 5.46
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev (1998) 5.25
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04
Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature (2003) 4.00
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem (2002) 3.21
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A (2005) 2.59
Gene-specific modulation of TAF10 function by SET9-mediated methylation. Mol Cell (2004) 2.56
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol (2006) 2.18
Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem (2008) 2.17
Pancreas and beta-cell development: from the actual to the possible. Development (2006) 2.13
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell (2008) 1.99
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J (2003) 1.89
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem (2003) 1.71
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem (2005) 1.65
Comparative analysis of insulin gene promoters: implications for diabetes research. Diabetes (2006) 1.65
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem (2005) 1.61
Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes (2005) 1.57
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol Cell Biol (2000) 1.55
In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells. Diabetes (2006) 1.53
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Mol Genet Metab (2007) 1.38
An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. Diabetes (2004) 1.29
Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Gastroenterology (2005) 1.22
Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets. Endocrinology (2008) 1.20
The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation. Transplantation (2004) 0.98
In vivo inhibition of focal adhesion kinase causes insulin resistance. J Physiol (2008) 0.86
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem (2002) 3.21
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes (2012) 1.98
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A (2009) 1.84
Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol (2009) 1.74
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem (2003) 1.71
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem (2005) 1.65
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem (2005) 1.61
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell (2006) 1.54
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol (2008) 1.52
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest (2013) 1.39
Isolation and proteomic analysis of mouse sperm detergent-resistant membrane fractions: evidence for dissociation of lipid rafts during capacitation. Biol Reprod (2005) 1.38
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis. Mol Genet Metab (2007) 1.38
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes (2007) 1.38
An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. J Clin Invest (2010) 1.36
Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis (2006) 1.31
Transcription factors direct the development and function of pancreatic beta cells. Trends Endocrinol Metab (2003) 1.31
Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab (2008) 1.28
Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes (2008) 1.20
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. J Clin Invest (2014) 1.19
Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes (2007) 1.17
Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA. Endocrinology (2013) 1.14
Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice. Biochem Biophys Res Commun (2006) 1.14
Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease. J Vis Exp (2012) 1.12
Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem (2006) 1.10
The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. J Hum Genet (2003) 1.10
PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress. Mol Endocrinol (2012) 1.10
Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol (2008) 1.08
Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes. J Biol Chem (2010) 1.06
The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Mol Endocrinol (2004) 1.05
Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. J Biol Chem (2008) 1.03
Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1. Mol Endocrinol (2006) 1.02
DeltaNp53 or p44: priming the p53 pump. Int J Biochem Cell Biol (2005) 1.02
Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Mol Endocrinol (2008) 1.01
RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects. Diabetes Care (2003) 1.00
Mouse SLLP1, a sperm lysozyme-like protein involved in sperm-egg binding and fertilization. Dev Biol (2005) 0.99
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol (2010) 0.99
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol (2010) 0.99
Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun (2007) 0.98
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1. Biochem Biophys Res Commun (2004) 0.98
Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus. J Clin Endocrinol Metab (2014) 0.93
Membrane association of estrogen receptor alpha mediates estrogen effect on MAPK activation. Biochem Biophys Res Commun (2002) 0.92
Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes. Diabetes (2002) 0.92
Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem (2009) 0.92
Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells. Mol Endocrinol (2012) 0.92
Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death. Mol Endocrinol (2012) 0.92
Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains. Am J Physiol Endocrinol Metab (2013) 0.91
Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia. Endocr J (2007) 0.91
Expression and function of Set7/9 in pancreatic islets. Islets (2010) 0.90
The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter. Biochemistry (2005) 0.90
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Cell Cycle (2011) 0.89
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One (2013) 0.88
Exendin-4 improves β-cell function in autophagy-deficient β-cells. Endocrinology (2013) 0.88
Facial solar UV exposure of Austrian farmers during occupation. Photochem Photobiol (2010) 0.88
Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice. Diabetes (2011) 0.87
Inducible pluripotent stem cells: not quite ready for prime time? Curr Opin Organ Transplant (2010) 0.86
Hypusine: a new target for therapeutic intervention in diabetic inflammation. Discov Med (2010) 0.86
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol (2010) 0.86
Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia (2016) 0.85
Oscillatory glucose flux in INS 1 pancreatic β cells: a self-referencing microbiosensor study. Anal Biochem (2010) 0.81
Characterization of a novel polyclonal anti-hypusine antibody. Springerplus (2013) 0.80
Regenerative medicine and tissue engineering: contribution of stem cells in organ transplantation. Curr Opin Organ Transplant (2009) 0.80
Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine. Pancreas (2011) 0.80
Development of insulin-producing cells from primitive biologic precursors. Curr Opin Organ Transplant (2009) 0.80
Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle. Biochem Biophys Res Commun (2013) 0.80
Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats. Endocr J (2007) 0.79
Mouse and human islets survive and function after coating by biosilicification. Am J Physiol Endocrinol Metab (2013) 0.79
UV exposition during typical lifestyle behavior in an urban environment. Photochem Photobiol (2010) 0.78
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. Amino Acids (2013) 0.77
Saturated free fatty acids: islet β cell "stressERs". Endocrine (2012) 0.77
Maintenance of Pdx1 mRNA translation in islet β-cells during the unfolded protein response. Mol Endocrinol (2014) 0.77
Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes. Am J Physiol Endocrinol Metab (2014) 0.77
Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes. J Biol Chem (2013) 0.76
Achieving "PeaK-A" insulin secretion. Diabetes (2013) 0.75
Insights into mentorship for endocrinologists. J Clin Endocrinol Metab (2012) 0.75
Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12. Biochim Biophys Acta (2006) 0.75
Editorial: in praise of scientific review officers. Mol Endocrinol (2014) 0.75
Management of the Nipple-Areola Complex in Selected Patients Undergoing Primary Breast Reconstruction: A Comparison of Immediate Replantation and Delayed Reconstruction. Ann Plast Surg (2017) 0.75
Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice. Biochem Biophys Res Commun (2013) 0.75
Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia. Metabolism (2007) 0.75
Stem cells and the future of organ transplantation. Curr Opin Organ Transplant (2010) 0.75