Published in J Mol Biol on December 21, 2009
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Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature (2006) 7.56
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
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Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
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Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature (2007) 3.26
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Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957. Proc Natl Acad Sci U S A (2009) 1.98
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Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci U S A (2003) 1.68
Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. J Biol Chem (2009) 1.52
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Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography. J Am Chem Soc (2005) 1.30
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Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex. J Biol Chem (2003) 1.30
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The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping. Mol Pharmacol (2004) 1.17
Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. Biochemistry (2002) 1.14
The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil. EMBO J (2008) 1.13
The oligomeric state and arrangement of the active bacterial translocon. J Biol Chem (2010) 1.09
Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies. Curr Opin Struct Biol (2010) 1.08
The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Mol Membr Biol (2006) 1.08
Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle. J Biol Chem (2009) 1.04
Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance. Mol Microbiol (2011) 1.01
A designed system for assessing how sequence affects alpha to beta conformational transitions in proteins. J Biol Chem (2001) 0.99
Remediation of chromium(VI) by a methane-oxidizing bacterium. Environ Sci Technol (2010) 0.99
Protein 4.2: a complex linker. Blood Cells Mol Dis (2009) 0.99
A switch in the mechanism of communication between the two DNA-binding sites in the SfiI restriction endonuclease. J Mol Biol (2007) 0.96
Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. J Biol Chem (2004) 0.96
"Zn-link": a metal-sharing interface that organizes the quaternary structure and catalytic site of the endoribonuclease, RNase E. Biochemistry (2005) 0.96
Designed alpha-helical tectons for constructing multicomponent synthetic biological systems. J Am Chem Soc (2009) 0.95
Structural basis for the role of Asp-120 in metallo-beta-lactamases. Biochemistry (2007) 0.95
Characterization and modelling of the hydrophobic domain of a sunflower oleosin. Planta (2002) 0.95
Squaring the circle in peptide assembly: from fibers to discrete nanostructures by de novo design. J Am Chem Soc (2012) 0.93
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Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia. Blood (2005) 0.91
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Mutational analysis of human CEACAM1: the potential of receptor polymorphism in increasing host susceptibility to bacterial infection. Cell Microbiol (2006) 0.91
An efficient, path-independent method for free-energy calculations. J Phys Chem B (2006) 0.90
Pharmacological chaperone for the structured domain of human prion protein. Proc Natl Acad Sci U S A (2010) 0.90
A knot or not a knot? SETting the record 'straight' on proteins. Comput Biol Chem (2003) 0.90
Cloning, sequence and expression of the lactate dehydrogenase gene from the human malaria parasite, Plasmodium vivax. Biotechnol Lett (2004) 0.90
Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the type III secretion system needle tip complex. Mol Microbiol (2014) 0.89
Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues. J Biol Inorg Chem (2008) 0.89
Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH. Biochemistry (2005) 0.89
Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block. J Chem Inf Model (2014) 0.88
LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells. Traffic (2010) 0.88
Synthetic peptides identify a second periplasmic site for the plug of the SecYEG protein translocation complex. FEBS Lett (2008) 0.85
Beyond the EX1 limit: probing the structure of high-energy states in protein unfolding. J Mol Biol (2004) 0.85
Interactions between voltage sensor and pore domains in a hERG K+ channel model from molecular simulations and the effects of a voltage sensor mutation. J Chem Inf Model (2013) 0.85
The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C. Biochim Biophys Acta (2011) 0.85
Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum. FEBS J (2007) 0.84
Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. J Biol Chem (2011) 0.84
The influence of intramolecular bridges on the dynamics of a protein folding reaction. Biochemistry (2002) 0.84
Toward a detailed description of the pathways of allosteric communication in the GroEL chaperonin through atomistic simulation. Biochemistry (2012) 0.83
A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4. Biochem Biophys Res Commun (2002) 0.82
Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Mol Biochem Parasitol (2005) 0.82
Absolute free-energy calculations of liquids using a harmonic reference state. J Phys Chem B (2007) 0.81
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. Proc Natl Acad Sci U S A (2011) 0.81
Effects of disulphide bridges on the activity and stability of the formate dehydrogenase from Candida methylica. Biotechnol Lett (2007) 0.81
Molecular dynamics simulations reveal a dielectric-responsive coronal structure in protein-polymer surfactant hybrid nanoconstructs. J Am Chem Soc (2014) 0.79
Structural and population-based evaluations of TBC1D1 p.Arg125Trp. PLoS One (2013) 0.79
Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design. Proc Natl Acad Sci U S A (2012) 0.79
Low energy pathways and non-native interactions: the influence of artificial disulfide bridges on the mechanism of folding. J Biol Chem (2005) 0.79
Density guided importance sampling: application to a reduced model of protein folding. Bioinformatics (2005) 0.78
Design, expression and characterisation of lysine-rich forms of the barley seed protein CI-2. Biochim Biophys Acta (2005) 0.78
Tuning the performance of an artificial protein motor. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 0.75
Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. J Med Chem (2014) 0.75
Corrigendum: Local and macroscopic electrostatic interactions in single α-helices. Nat Chem Biol (2015) 0.75
A double mutant of highly purified Geobacillus stearothermophilus lactate dehydrogenase recognises l-mandelic acid as a substrate. Enzyme Microb Technol (2013) 0.75
Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli. J Mol Microbiol Biotechnol (2010) 0.75
Identification of novel small molecule TGF-β antagonists using structure-based drug design. J Comput Aided Mol Des (2013) 0.75
Decorating Self-Assembled Peptide Cages with Proteins. ACS Nano (2017) 0.75
Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural model. Rejuvenation Res (2008) 0.75
Estimating the energetic contribution of hydrogen bonding to the stability of Candida methylica formate dehydrogenase by using double mutant cycle. Biotechnol Lett (2004) 0.75