Published in Clin Biochem on December 21, 2009
Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol (2000) 16.47
Universal definition of myocardial infarction. J Am Coll Cardiol (2007) 8.68
Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med (2009) 8.05
Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med (2009) 6.62
Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA (2007) 6.06
A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med (2009) 5.81
National Hospital Ambulatory Medical Care Survey: 2005 emergency department summary. Adv Data (2007) 4.51
Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation (2007) 4.11
Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation (2002) 3.74
Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome. Circulation (2007) 3.62
Emergency department crowding and thrombolysis delays in acute myocardial infarction. Ann Emerg Med (2004) 3.62
Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations. Clin Chem (2003) 2.96
Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35. Eur Heart J (2008) 2.92
National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. Clin Chem (1999) 2.90
Biomarkers in acute cardiac disease: the present and the future. J Am Coll Cardiol (2006) 2.89
Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide. Circulation (2002) 2.86
Prevalence and determinants of troponin T elevation in the general population. Circulation (2006) 2.84
C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol (2003) 2.51
Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem (2005) 2.43
Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Clin Chim Acta (2007) 2.31
Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ (2005) 2.23
European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. Am Heart J (2002) 2.11
Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clin Chem (2008) 2.11
Safety and efficiency of emergency department assessment of chest discomfort. CMAJ (2004) 2.09
Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol (2005) 2.07
A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem (2009) 2.07
Emergency department overcrowding and ambulance transport delays for patients with chest pain. CMAJ (2003) 2.06
Cardiac troponin T composition in normal and regenerating human skeletal muscle. Clin Chem (1997) 1.96
Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study. Circulation (2006) 1.94
Assessing the requirement for the 6-hour interval between specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies. Clin Chem (2006) 1.94
Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18. Eur Heart J (2008) 1.88
Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. Circulation (2001) 1.86
Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem (2009) 1.82
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Clin Chem (2007) 1.82
Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values. J Am Coll Cardiol (2007) 1.77
Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia. J Am Coll Cardiol (2009) 1.73
Prognostic value of biomarkers during and after non-ST-segment elevation acute coronary syndrome. J Am Coll Cardiol (2009) 1.71
Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making. Clin Chem (2008) 1.62
Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction. Clin Chem (2005) 1.58
Assessment of the multiple-biomarker approach for diagnosis of myocardial infarction in patients presenting with symptoms suggestive of acute coronary syndrome. Clin Chem (2008) 1.55
Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem (2003) 1.51
Enzyme linked immuno assay of cardiac troponin T for the detection of acute myocardial infarction in patients. J Mol Cell Cardiol (1989) 1.45
Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein. Circulation (2005) 1.36
Earlier detection of myocardial injury in a preliminary evaluation using a new troponin I assay with improved sensitivity. Am J Clin Pathol (2007) 1.34
Highly sensitive cardiac troponin T values remain constant after brief exercise- or pharmacologic-induced reversible myocardial ischemia. Clin Chem (2008) 1.32
Emergency department utilization in the United States and Ontario, Canada. Acad Emerg Med (2007) 1.30
Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction. Am Heart J (2004) 1.26
Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. Clin Chem (2009) 1.25
The variability of results between point-of-care testing glucose meters and the central laboratory analyzer. Arch Pathol Lab Med (2006) 1.13
Serial increased cardiac troponin T predicts mortality in asymptomatic patients treated with chronic haemodialysis. Ann Clin Biochem (2009) 1.10
Long-term health outcomes associated with detectable troponin I concentrations. Clin Chem (2007) 1.09
Elevated cardiac troponin is an independent risk factor for short- and long-term mortality in medical intensive care unit patients. Crit Care Med (2008) 1.09
The impact of the ESC/ACC redefinition of myocardial infarction and new sensitive troponin assays on the frequency of acute myocardial infarction. Am Heart J (2006) 1.07
The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing. Am Heart J (2007) 1.06
Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector. Clin Chem (2006) 1.03
Profiles of serial changes in cardiac troponin T concentrations and outcome in ambulatory patients with chronic heart failure. J Am Coll Cardiol (2009) 1.01
Chasing troponin: how low can you go if you can see the rise? J Am Coll Cardiol (2006) 0.98
Comparative sensitivity of cardiac troponin I and lactate dehydrogenase isoenzymes for diagnosing acute myocardial infarction. Clin Chem (1996) 0.96
Myoglobinuria, hemoglobinuria, and acute renal failure. Clin Chem (1989) 0.93
Measurement and clinical significance of circulating PAPP-A in ACS patients. Clin Chim Acta (2007) 0.90
Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population. Clin Chem (2009) 0.89
Defining a role for novel biomarkers in acute coronary syndromes. Clin Chem (2008) 0.88
Sites of interleukin-6 release in patients with acute coronary syndromes and in patients with congestive heart failure. Am J Cardiol (2000) 0.88
Development of an optimized multimarker strategy for early risk assessment of patients with acute coronary syndromes. Clin Chim Acta (2008) 0.85
Usefulness of troponin levels below the diagnostic cut-off level for acute myocardial infarction in predicting prognosis in unselected patients admitted to the coronary care unit. Am J Cardiol (2007) 0.85
Cardiovascular biomarkers: the state of the art in 2006. Clin Chim Acta (2007) 0.85
Myeloperoxidase is not useful for the early assessment of patients with chest pain. Clin Biochem (2009) 0.84
PAPP-A as a marker of increased long-term risk in patients with chest pain. Clin Biochem (2009) 0.84
Cardiac point of care testing: a focused review of current National Academy of Clinical Biochemistry guidelines and measurement platforms. Clin Biochem (2008) 0.83
Pregnancy-associated plasma protein-A elevation in patients with acute coronary syndrome and subsequent atorvastatin therapy. Am J Cardiol (2008) 0.83
"Upstream markers" provide for early identification of patients at high risk for myocardial necrosis and adverse outcomes. Clin Chim Acta (2007) 0.83
Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: observations from the PROTECT-TIMI 30 Trial. Am Heart J (2009) 0.83
The declining prevalence of ST elevation myocardial infarction in patients presenting with acute coronary syndromes. Heart (2005) 0.82
Creatine kinase MB isoforms in patients with skeletal muscle injury: ramifications for early detection of acute myocardial infarction. Clin Chem (1992) 0.81
Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain. Clin Biochem (2002) 0.79
Acute coronary syndrome biomarkers: the need for more adequate reporting. Circulation (2004) 0.78
Intravenous administration of low molecular weight and unfractionated heparin elicits a rapid increase in serum pregnancy-associated plasma protein A. Clin Chem (2009) 0.78
Delta creatine kinase-MB outperforms myoglobin at two hours during the emergency department identification and exclusion of troponin positive non-ST-segment elevation acute coronary syndromes. Ann Emerg Med (2004) 0.78
A change in serum myoglobin to detect acute myocardial infarction in patients with normal troponin I levels. Am J Cardiol (2004) 0.78
Another potential marker linking gender and cardiac mortality: PAPP-A--a new marker in risk stratification for women presenting with chest pain. Clin Chim Acta (2009) 0.76
Serial cardiac troponin T measurements in haemodialysis patients: absolute versus changing concentrations? Ann Clin Biochem (2009) 0.76
Challenges of implementing point-of-care testing (POCT) glucose meters in a pediatric acute care setting. Clin Biochem (2004) 0.75
Improved early risk stratification and diagnosis of myocardial infarction, using a novel troponin I assay concept. Eur J Clin Invest (2005) 0.75
CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ (2010) 28.70
Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA (2005) 23.44
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (2009) 22.18
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet (2008) 13.15
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med (2009) 12.16
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol (2009) 11.80
Universal definition of myocardial infarction. Circulation (2007) 11.69
Third universal definition of myocardial infarction. J Am Coll Cardiol (2012) 8.59
Third universal definition of myocardial infarction. Circulation (2012) 8.47
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Third universal definition of myocardial infarction. Eur Heart J (2012) 7.98
CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol (2010) 7.04
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med (2015) 5.28
Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet (2008) 5.27
Screening for intimate partner violence in health care settings: a randomized trial. JAMA (2009) 4.80
Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA (2012) 4.58
2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2014) 4.57
Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials. CMAJ (2004) 4.53
Internet versus mailed questionnaires: a randomized comparison (2). J Med Internet Res (2004) 4.45
Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol (2011) 4.43
Clinical decision rules to rule out subarachnoid hemorrhage for acute headache. JAMA (2013) 4.34
Off-pump or on-pump coronary-artery bypass grafting at 30 days. N Engl J Med (2012) 4.32
Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year. N Engl J Med (2013) 4.27
An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am (2002) 4.25
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol (2008) 4.24
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med (2008) 4.03
Failure to engage hospitalized elderly patients and their families in advance care planning. JAMA Intern Med (2013) 3.77
A new 'mechanistic-practical" framework for designing and interpreting randomized trials. J Clin Epidemiol (2008) 3.75
Acute myocardial infarction and renal dysfunction: a high-risk combination. Ann Intern Med (2002) 3.71
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial. Lancet (2014) 3.70
Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial. JAMA Intern Med (2013) 3.65
Physicians' and patients' choices in evidence based practice. BMJ (2002) 3.57
CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Int J Surg (2011) 3.57
GRADE guidelines 6. Rating the quality of evidence--imprecision. J Clin Epidemiol (2011) 3.54
Serum cardiac troponins and N-terminal pro-brain natriuretic peptide: a staging system for primary systemic amyloidosis. J Clin Oncol (2004) 3.43
Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry (2005) 3.41
Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am (2003) 3.36
Patients at the center: in our practice, and in our use of language. ACP J Club (2004) 3.32
Cardiac Complications in Patients Undergoing Major Noncardiac Surgery. N Engl J Med (2015) 3.31
Randomized controlled trials of surgical interventions. Ann Surg (2010) 3.30
Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. J Psychosom Res (2002) 3.27
Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware. Clin Chem (2012) 3.25
Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem (2009) 3.24
Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22
Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol (2004) 3.19
Internal fixation compared with arthroplasty for displaced fractures of the femoral neck. A meta-analysis. J Bone Joint Surg Am (2003) 3.14
Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. CMAJ (2010) 3.13
Trends in incidence, severity, and outcome of hospitalized myocardial infarction. Circulation (2010) 3.07
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06
Depression as a risk factor for mortality after acute myocardial infarction. Am J Cardiol (2003) 2.87
Redefinition of myocardial infarction: prospective evaluation in the community. Circulation (2006) 2.76
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol (2011) 2.69
Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ (2012) 2.69
Early mobilisation for patients following acute myocardiac infarction: a systematic review and meta-analysis of experimental studies. Int J Nurs Stud (2009) 2.69
Operative management of displaced femoral neck fractures in elderly patients. An international survey. J Bone Joint Surg Am (2005) 2.68
Internet versus mailed questionnaires: a controlled comparison (2). J Med Internet Res (2004) 2.59
Clinical expertise in the era of evidence-based medicine and patient choice. ACP J Club (2002) 2.58
Features of effective computerised clinical decision support systems: meta-regression of 162 randomised trials. BMJ (2013) 2.58
Social support and prognosis in patients at increased psychosocial risk recovering from myocardial infarction. Health Psychol (2007) 2.57
Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies. J Am Coll Cardiol (2009) 2.56
Users' guide to detecting misleading claims in clinical research reports. BMJ (2004) 2.55
Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation (2014) 2.50
Approaches to screening for intimate partner violence in health care settings: a randomized trial. JAMA (2006) 2.50
Regional systems of care to optimize timeliness of reperfusion therapy for ST-elevation myocardial infarction: the Mayo Clinic STEMI Protocol. Circulation (2007) 2.47
Preparing the United States for high-sensitivity cardiac troponin assays. J Am Coll Cardiol (2013) 2.46
Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack. CMAJ (2011) 2.45
Randomized clinical trials--removing unnecessary obstacles. N Engl J Med (2013) 2.43
Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem (2005) 2.43
The quality of randomized trial reporting in leading medical journals since the revised CONSORT statement. Contemp Clin Trials (2005) 2.40
Understanding receiver operating characteristic (ROC) curves. CJEM (2006) 2.38
Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Clin Chim Acta (2007) 2.31
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol (2008) 2.31
2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation (2014) 2.30
High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. Am Heart J (2013) 2.30
Perioperative myocardial infarction. Circulation (2009) 2.30
Surgery for hip fractures: Does surgical delay affect outcomes? Indian J Orthop (2011) 2.30
Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department. Circulation (2010) 2.29
Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. J Am Coll Cardiol (2013) 2.28
Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ (2005) 2.23
Applicability of the AGREE II instrument in evaluating the development process and quality of current National Academy of Clinical Biochemistry guidelines. Clin Chem (2012) 2.21
Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol (2007) 2.20
Systematic review to determine whether participation in a trial influences outcome. BMJ (2005) 2.19
Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas (2010) 2.19
Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med (2015) 2.16
Head CT for nontrauma patients in the emergency department: clinical predictors of abnormal findings. Radiology (2012) 2.15
European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. Am Heart J (2002) 2.11
Interpreting changes in troponin--clinical judgment is essential. Clin Chem (2012) 2.06
A prospective cohort study of patients with transient ischemic attack to identify high-risk clinical characteristics. Stroke (2013) 2.03
How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J (2012) 2.00
Assessing the requirement for the 6-hour interval between specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies. Clin Chem (2006) 1.94