Phospholipid and sphingolipid metabolism in Leishmania.

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Published in Mol Biochem Parasitol on December 23, 2009

Authors

Kai Zhang1, Stephen M Beverley

Author Affiliations

1: Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA. kai.zhang@ttu.edu

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Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol (2008) 12.34

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol (1992) 11.24

The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem (1956) 7.90

Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem (2001) 6.42

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem (2002) 4.52

Electrospray mass spectrometry of phospholipids. Mass Spectrom Rev (2003) 4.18

The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58

The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J Cell Sci (1999) 3.40

Cholesterol interactions with phospholipids in membranes. Prog Lipid Res (2002) 3.34

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta (2003) 3.08

Identification of a family of animal sphingomyelin synthases. EMBO J (2003) 3.03

Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis. Biochemistry (2002) 2.59

Phospholipid signaling. Cell (1995) 2.43

Plasmalogens: biosynthesis and functions. Prog Lipid Res (2001) 2.37

Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature (2004) 2.36

Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. J Lipid Res (2008) 2.32

Metabolism and functions of phosphatidylserine. Prog Lipid Res (2005) 2.31

Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem (1997) 2.21

Fatty acid synthesis by elongases in trypanosomes. Cell (2006) 2.18

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A (2000) 2.11

Structure of the lipophosphoglycan from Leishmania major. J Biol Chem (1990) 2.10

Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli. Mol Microbiol (1999) 2.06

Inositol phosphorylceramide, a novel substance and the chief member of a major group of yeast sphingolipids containing a single inositol phosphate. J Biol Chem (1974) 1.99

Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. J Biol Chem (2006) 1.97

Isolation and partial characterization of a major inositol-containing lipid in baker's yeast, mannosyl-diinositol, diphosphoryl-ceramide. Proc Natl Acad Sci U S A (1969) 1.96

Leishmaniasis: drugs in the clinic, resistance and new developments. Drug Resist Updat (2004) 1.96

The size of lipid rafts: an atomic force microscopy study of ganglioside GM1 domains in sphingomyelin/DOPC/cholesterol membranes. Biophys J (2002) 1.91

Structure of the lipid moiety of the Leishmania donovani lipophosphoglycan. J Biol Chem (1987) 1.89

Eukaryotic phospholipid biosynthesis. Annu Rev Biochem (1995) 1.88

Glycerolipid biosynthesis in peroxisomes via the acyl dihydroxyacetone phosphate pathway. Ann N Y Acad Sci (1982) 1.83

Acylation-dependent protein export in Leishmania. J Biol Chem (2000) 1.77

A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein. J Biol Chem (1986) 1.67

Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem (2000) 1.65

Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids. J Biol Chem (1990) 1.64

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem (1999) 1.63

Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. Arch Biochem Biophys (1984) 1.62

Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes. Proc Natl Acad Sci U S A (2006) 1.60

Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism. EMBO J (1999) 1.59

Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proc Natl Acad Sci U S A (2006) 1.58

Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J Biol Chem (2005) 1.57

Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease. J Biol Chem (1990) 1.56

Purification and characterization of the membrane-form variant surface glycoprotein hydrolase of Trypanosoma brucei. J Biol Chem (1986) 1.54

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Flagellar membrane localization via association with lipid rafts. J Cell Sci (2009) 1.49

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Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc Natl Acad Sci U S A (1996) 1.46

Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob Agents Chemother (2004) 1.46

Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Mol Microbiol (2004) 1.45

Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J (2007) 1.44

Metabolism of Leishmania: proven and predicted. Trends Parasitol (2007) 1.44

Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity. Curr Biol (2001) 1.43

Sphingolipids are essential for differentiation but not growth in Leishmania. EMBO J (2003) 1.40

Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis. J Biol Chem (2007) 1.39

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Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools. Biochem J (2006) 1.37

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem (2002) 1.35

The glycoinositol phospholipids of Leishmania mexicana promastigotes. Evidence for the presence of three distinct pathways of glycolipid biosynthesis. J Biol Chem (1993) 1.35

Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts. J Immunol (2006) 1.31

Yeast sphingolipids: metabolism and biology. Biochim Biophys Acta (2002) 1.31

Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem (1997) 1.30

Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy (2009) 1.26

Developmentally regulated sphingolipid synthesis in African trypanosomes. Mol Microbiol (2008) 1.26

Plasmenylethanolamine facilitates rapid membrane fusion: a stopped-flow kinetic investigation correlating the propensity of a major plasma membrane constituent to adopt an HII phase with its ability to promote membrane fusion. Biochemistry (1994) 1.24

Treatment of New World cutaneous leishmaniasis with miltefosine. Trans R Soc Trop Med Hyg (2006) 1.24

Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania. Mol Biochem Parasitol (2000) 1.23

GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida. FEBS Lett (2001) 1.21

Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity. J Bacteriol (1992) 1.21

Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha. J Biol Chem (1989) 1.20

Phospholipase A(2) isoforms: a perspective. Cell Signal (2003) 1.19

Does cholesterol discriminate between sphingomyelin and phosphatidylcholine in mixed monolayers containing both phospholipids? Chem Phys Lipids (1996) 1.19

Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions. Antimicrob Agents Chemother (2005) 1.18

Function and assembly of the Leishmania surface coat. Int J Parasitol (2001) 1.18

Cooperation between apoptotic and viable metacyclics enhances the pathogenesis of Leishmaniasis. PLoS One (2009) 1.17

Lipid analyses of isolated surface membranes of Leishmania donovani promastigotes. Lipids (1985) 1.16

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways. J Cell Biol (1994) 1.15

Lipids of Leishmania promastigotes. J Parasitol (1979) 1.15

The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol. Mol Microbiol (2006) 1.14

Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei. Biochem J (2006) 1.14

Characterization of inositol lipids from Leishmania donovani promastigotes: identification of an inositol sphingophospholipid. J Lipid Res (1986) 1.14

Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties. J Antibiot (Tokyo) (1991) 1.14

Surface antigens of Leishmania mexicana amastigotes: characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid. J Cell Sci (1994) 1.12

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement. Antimicrob Agents Chemother (2008) 1.12

Apoptosis driven infection. Autoimmunity (2007) 1.11

De novo sphingolipid synthesis is essential for viability, but not for transport of glycosylphosphatidylinositol-anchored proteins, in African trypanosomes. Eukaryot Cell (2007) 1.10

Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. J Cell Sci (2008) 1.10

AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells. Mol Gen Genet (1996) 1.10

Phosphatidylethanolamine is the donor of the terminal phosphoethanolamine group in trypanosome glycosylphosphatidylinositols. EMBO J (1993) 1.09

Stage-specific glycosphingolipids from amastigote forms of Leishmania (L.) amazonensis. Immunogenicity and role in parasite binding and invasion of macrophages. J Biol Chem (1993) 1.09

Ceramide as an activator lipid of cathepsin D. Adv Exp Med Biol (2000) 1.08

The myo-inositol-1-phosphate synthase gene is essential in Trypanosoma brucei. Biochem Soc Trans (2005) 1.08

Is the high propensity of ethanolamine plasmalogens to form non-lamellar lipid structures manifested in the properties of biomembranes? Chem Phys Lipids (1996) 1.07

Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom (2007) 1.04

Phosphatidylserine decarboxylases, key enzymes of lipid metabolism. IUBMB Life (2009) 1.03

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids. Mol Microbiol (2007) 1.03

Programmed cell death in trypanosomatids: a way to maximize their biological fitness? Trends Parasitol (2004) 1.02

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei. Mol Microbiol (2009) 1.01

Generation of myo-inositol-auxotrophic Leishmania mexicana mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene. Mol Biochem Parasitol (2002) 1.01

Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote. Eukaryot Cell (2003) 1.01

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